Advances in measurements and instrumentation leveraging embedded systems.

The expression "embedded systems" is used in different contexts and with broad meanings, but in electronics, it refers to systems that contain peripherals and a firmware for local digital data processing, often on a single board. Embedded systems are often associated with the field of computer science, emphasizing the software and programming aspects of systems. However, the progress made on the hardware side cannot be ignored, and without such technological advances, embedded systems would not exist.

Indocyanine Green to Assess Vascularity of Ileal Conduit Anastomosis During Pelvic Exenteration for Recurrent/Persistent Gynecological Cancer: A Pilot Study.

Introduction: Pelvic exenteration performed for recurrent/persistent gynecological malignancies has been associated with urological short- and long-term morbidity due to altered vascularization of tissues for previous radiotherapy. The aims of the present study were to describe the use of intravenous indocyanine green (ICG) to assess vascularity of urinary diversion (UD) after pelvic exenteration for gynecologic cancers, to evaluate the feasibility and safety of this technique, and to assess the postoperative complications.

Methods: Prospective, observational, single-center, pilot study including consecutive patients undergoing anterior or total pelvic exenteration due to persistent/recurrent gynecologic cancers between August 2020 and March 2021 at Fondazione Policlinico Gemelli IRCCS, Rome, Italy.

The Effect of Metal Cations on the Aqueous Behavior of Dopamine. Thermodynamic Investigation of the Binary and Ternary Interactions with Cd, Cu and UO in NaCl at Different Ionic Strengths and Temperatures.

The interactions of dopamine [2-(3,4-Dihydroxyphenyl)ethylamine, (Dop)] with cadmium(II), copper(II) and uranyl(VI) were studied in NaCl(aq) at different ionic strengths (0 ≤ /mol dm ≤ 1.0) and temperatures (288.15 ≤ /K ≤ 318.

How COVID-19 Has Affected Caregivers' Burden of Patients with Dementia: An Exploratory Study Focusing on Coping Strategies and Quality of Life during the Lockdown.

COVID-19 has caused a public and international health emergency, leading to isolation and social distancing. These restrictions have had a significant impact on the caregivers of people with dementia, increasing the burden of patient management. The purpose of this study was to investigate the stress perceived by caregivers of patients with Alzheimer's disease (AD) during the pandemic.

Trace elements in stomach oil of Scopoli's shearwater (Calonectris diomedea) from Linosa's colony.

Calonectris diomedea is a colonial Procellariiform breeding on Mediterranean islands. The stomach oil produced during chick rearing is a peculiar trait of this species. The composition of the stomach oil is likely to reflect the composition of the prey ingested and might reveal the contaminants uptake with prey becoming a possible tool for the marine pollution monitoring.

Toward the Rational Design of Organic Solar Photovoltaics: Application of Molecular Structure Methods to Donor Polymers.

Conjugated polymers are promising candidates in the design of polymer solar cell materials with suitable electronic properties. Recent studies show that the use of different functional groups as side chain in thiophene-based polymers changes the electronic and conformation structures. Here we design new thiophene-based molecules by replacing the hydrogen attached to the backbone of P3MT with electron-donating and electron-withdrawing groups.

Runs of homozygosity in the Italian goat breeds: impact of management practices in low-input systems.

Background: Climate and farming systems, several of which are considered as low-input agricultural systems, vary between goat populations from Northern and Southern Italy and have led to different management practices. These processes have impacted genome shaping in terms of inbreeding and regions under selection and resulted in differences between the northern and southern populations. Both inbreeding and signatures of selection can be pinpointed by the analysis of runs of homozygosity (ROH), which provides useful information to assist the management of this species in different rural areas.

Simplified patient-specific renal dosimetry in Lu therapy: a proof of concept.

Purpose: The aim of this proof-of-concept study is to propose a simplified personalized kidney dosimetry procedure in Lu peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumors and metastatic prostate cancer. It relies on a single quantitative SPECT/CT acquisition and multiple radiometric measurements executed with a collimated external probe, properly directed on kidneys.

Methods: We conducted a phantom study involving external count-rate measurements in an abdominal phantom setup filled with activity concentrations of Tc, reproducing patient-relevant organ effective half-lives occurring in Lu PRRT.

Fluorescent Biosensors Based on Silicon Nanowires.

Nanostructures are arising as novel biosensing platforms promising to surpass current performance in terms of sensitivity, selectivity, and affordability of standard approaches. However, for several nanosensors, the material and synthesis used make the industrial transfer of such technologies complex. Silicon nanowires (NWs) are compatible with Si-based flat architecture fabrication and arise as a hopeful solution to couple their interesting physical properties and surface-to-volume ratio to an easy commercial transfer.

Radioactivity, Metals Pollution and Mineralogy Assessment of a Beach Stretch from the Ionian Coast of Calabria (Southern Italy).

In the present article, a case study is reported regarding an investigation carried out in order to assess radioactivity concentration, heavy metals pollution and mineralogy of a beach stretch extending from Soverato to Squillace municipalities of the Ionian coast of Calabria, South of Italy, a popular tourist destination, especially in summer. The analysis of radionuclides contents was performed by using a High Purity Germanium (HPGe) gamma-ray detector, in order to quantify the average specific activity of Ra, Th and K natural radionuclides and Cs anthropogenic radioisotope. The absorbed dose rate and the annual effective dose equivalent radiological hazard indices were also estimated.

Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors.

Brain tumors are particularly aggressive and represent a significant cause of morbidity and mortality in adults and children, affecting the global population and being responsible for 2.6% of all cancer deaths (as well as 30% of those in children and 20% in young adults). The blood-brain barrier (BBB) excludes almost 100% of the drugs targeting brain neoplasms, representing one of the most significant challenges to current brain cancer therapy.

Sentinel Lymph Node in Aged Endometrial Cancer Patients "The SAGE Study": A Multicenter Experience.

Objective: The incidence of endometrial cancer is increasing in elderly people. Considering that aging progressively affects lymphatic draining function, we aimed to define its impact on IGC uptake during SLN mapping.

Methods: A multicenter retrospective cohort of endometrial cancer patients with apparently early-stage endometrial cancer undergoing complete surgical staging with SLN dissection was identified in four referral cancer centers from May 2015 to March 2021.

Congenital bilateral choanal atresia: an endoscopic approach with multi-flaps supported by neuronavigated CT.

We present a case of a 2-month-old patient with CHARGE syndrome, cerebral haemorrhage and bilateral congenital choanal atresia (CCA). He was admitted to our otorhinolaryngology unit to solve his congenital bilateral choanal atresia proposing a transnasal endoscopic surgery. A study of CT of the skull showed that the air column was interrupted on both sides of nasal cavities; a nasal endoscopy with neonatology flexible optics showed the presence of a membrane and bony structure obstructing the passage into the nasopharynx.

molecular dynamics simulations and experimental speciation study of levofloxacin under different pH conditions.

Levofloxacin is an extensively employed broad-spectrum antibiotic belonging to the fluoroquinolone class. Despite the extremely wide usage of levofloxacin for a plethora of diseases, the molecular characterization of this antibiotic appears quite poor in the literature. Moreover, the acid-base properties of levofloxacin - crucial for the design of efficient removal techniques from wastewaters - have never extensively been investigated so far.

Cross-sectional study to develop and describe psychometric characteristics of a patient-reported instrument (PROFFIT) for measuring financial toxicity of cancer within a public healthcare system.

Objectives: To measure and explain financial toxicity (FT) of cancer in Italy, where a public healthcare system exists and patients with cancer are not expected (or only marginally) to pay out-of-pocket for healthcare.

Setting: Ten clinical oncological centres, distributed across Italian macroregions (North, Centre, South and Islands), including hospitals, university hospitals and national research institutes.

Participants: From 8 October 2019 to 11 December 2019, 184 patients, aged 18 or more, who were receiving or had received within the previous 3 months active anticancer treatment were enrolled, 108 (59%) females and 76 (41%) males.

Synthesis, Characterization and Photocatalytic Behavior of SiO @nitrized-TiO Nanocomposites Obtained by a Straightforward Novel Approach.

We report on the facile synthesis of SiO @nitrized-TiO nanocomposite (NST) by calcination of TiO xerogel with OctaAmmonium POSS® (N-POSS; POSS=polyhedral oligomeric silsesquioxanes). The as-obtained nanoporous mixed oxide is constituted by uniformly distributed SiO and nitrized-TiO , where the silica component is present in an amorphous state and TiO in an anatase/rutile mixed phase (92.1 % vs.

Early stages of aggregation in fluid mixtures of dimers and spheres: a theoretical and simulation study.

We use Monte Carlo simulation and the Reference Interaction Site Model (RISM) theory of molecular fluids to investigate a simple model of colloidal mixture consisting of dimers, made up of two tangent hard monomers of different size, and hard spheres. In addition to steric repulsion, the two species interact a square-well attraction only between small monomers and spheres. Recently, we have characterized the low-temperature regime of this mixture by Monte Carlo, reporting on the spontaneous formation of a wide spectrum of supramolecular aggregates [Prestipino , , 2019, , 9272].

Impact and trends in embedding field programmable gate arrays and microcontrollers in scientific instrumentation.

Microcontrollers and field-programmable gate arrays have been largely leveraged in scientific instrumentation since decades. Recent advancements in the performance of these programmable digital devices, with hundreds of I/O pins, up to millions of logic cells, >10 Gb/s connectivity, and hundreds of MHz multiple clocks, have been accelerating this trend, extending the range of functions. The diversification of devices from very low-cost 8-bit microcontrollers up to 32-bit ARM-based ones and a system of chip combining programmable logic with processors make them ubiquitous in modern electronic systems, addressing diverse challenges from ultra-low power operation, with sub-µA quiescent current in sleep mode for portable and Internet of Things applications, to high-performance computing, such as in machine vision.

The Solution Behavior of Dopamine in the Presence of Mono and Divalent Cations: A Thermodynamic Investigation in Different Experimental Conditions.

The interactions of dopamine [2-(3,4-Dihydroxyphenyl)ethylamine, (Dop)] with methylmercury(II) (CHHg), magnesium(II), calcium(II), and tin(II) were studied in NaCl(aq) at different ionic strengths and temperatures. Different speciation models were obtained, mainly characterized by mononuclear species. Only for Sn we observed the formation of binuclear complexes (ML and MLOH (charge omitted for simplicity); M = Sn, L = Dop).

Structural, energetic and kinetic database of catalytic reactions: Benzyl alcohol to benzaldehyde oxidation on MnO clusters.

Data here reported are connected with the research article "Benzyl Alcohol to Benzaldehyde Oxidation on MnO Clusters: Unraveling Atomistic Features" Gueci et al. [1]. This work described and discussed structural and energetic results, calculated by Density Functional Theory (DFT).

A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage Endometrial Cancer: The ROMANHY Trial.

Objective: This prospective randomized trial aimed to assess the impact of the uterine manipulator in terms of lymph vascular space invasion (LVSI) in patients undergoing minimally invasive staging for early-stage endometrial cancer.

Methods: In this multicentric randomized trial, enrolled patients were randomly allocated in two groups according to the no use (arm A) or the use (arm B) of the uterine manipulator. Inclusion criteria were G1-G2 early-stage endometrial cancer at preoperative evaluation.

Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy.

Visceral leishmaniasis (VL) caused by Leishmania infantum is endemic in the Mediterranean basin with most of the infected human patients remaining asymptomatic. Recently, the saurian-associated Leishmania tarentolae was detected in human blood donors and in sheltered dogs. The circulation of L.

Prevalence and risk factors associated with cat parasites in Italy: a multicenter study.

Background: Parasites that infect cats include protozoa, helminths and arthropods, many of which are transmissible to humans. Effective control relies on a good knowledge of parasite distribution and the risk factors for infection. The present study was aimed at evaluating the prevalence of major feline parasites in Italy and the risk factors associated with their occurrence.