Systemic and Cardiac Microvascular Dysfunction in Hypertension.

Hypertension exerts a profound impact on the microcirculation, causing both structural and functional alterations that contribute to systemic and organ-specific vascular damage. The microcirculation, comprising arterioles, capillaries, and venules with diameters smaller than 20 μm, plays a fundamental role in oxygen delivery, nutrient exchange, and maintaining tissue homeostasis. In the context of hypertension, microvascular remodeling and rarefaction result in reduced vessel density and elasticity, increasing vascular resistance and driving end-organ damage.

Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue.

Current literature regarding cancer risk in rheumatic and musculoskeletal diseases (RMDs) is particularly poor and controversial, even though the incidence of malignancy in some patients with RMDs is considered to be increased compared with the general population. Malignancy may be a major comorbidity in subjects with spondyloarthritis (SpA) as the result of multifactorial mechanisms, from disease pathogenesis to the iatrogenic effect of immunomodulating drugs. Several recommendations for screening and management of cancer risk have been developed in recent years with the aim of improving the different outcomes in these patients.

From spectroscopic data variability to optimal preprocessing: leveraging multivariate error in almond powder adulteration of different grain size.

Analysing samples in their original form is increasingly crucial in analytical chemistry due to the need for efficient and sustainable practices. Analytical chemists face the dual challenge of achieving accuracy while detecting minute analyte quantities in complex matrices, often requiring sample pretreatment. This necessitates the use of advanced techniques with low detection limits, but the emphasis on sensitivity can conflict with efforts to simplify procedures and reduce solvent use.

Doubly Metathetic NiCl-Catalyzed Coupling Between Bis(2-oxazolines) and Aldehydes: A Novel Access to Bis(ester-imine) Derivatives.

The coupling between bis(2-oxazolines) and two equivalents of aromatic aldehydes in the presence of catalytic amounts of NiCl affords an ester-imine product in synthetically useful yields. This virtually unknown, 100% atom-economic transformation involves the formal metathesis between the C=N double bond of the bis(2-oxazoline) moiety, which undergoes ring-opening, and the C=O double bond of the aldehyde. The scope of this transformation is studied, and a mechanism is proposed based on DFT calculations.

Probabilistic Approach for Assessing the Occupational Risk of Olfactometric Examiners: Methodology Description and Application to Real Exposure Scenario.

Human examiners, known as panelists, are exposed to an unknown occupational exposure risk while determining odor concentration (C) using dynamic olfactometry. In the literature, a few papers, based on a deterministic approach, have been proposed to establish this occupational risk. As a result, the purpose of this study is to develop and apply a probabilistic approach, based on the randomization of exposure parameters, for assessing and evaluating the occupational exposure risk among olfactometric examiners.

Lineshape of Amplitude-Modulated Stimulated Raman Spectra.

The amplitude modulation of a pump field and the phase-sensitive detection of a pump-induced intensity change of a probe field encompass a common practice in nonlinear spectroscopies to enhance the detection sensitivity. A drawback of this approach arises when the modulation frequency is comparable to the width of the spectral feature of interest, since the presence of sidebands in the amplitude-modulated pump field provides distortion to the observed spectral lineshape. This represents a problem when accurate measurements of spectral lineshapes and line positions are pursued, as recently happened in our group with the metrology of the Q(1) line in the 1-0 band of molecular hydrogen.

Follow-up of early breast cancer in a public health system: A 2024 AIGOM consensus project.

Breast cancer stands as the most frequently diagnosed cancer and the primary cause of cancer-related mortality among women worldwide, including Italy. With the increasing number of survivors, many are enrolled in regular follow-up programs. However, adherence to recommendations from scientific societies (such as ASCO, ESMO, AIOM) for breast cancer follow-up management varies in daily clinical practice across different cancer centers, potentially resulting in unequal management and escalating costs.

Impairing protein-protein interactions in an essential tRNA modification complex: An innovative antimicrobial strategy against Pseudomonas aeruginosa.

Protein-protein interactions (PPIs) have been recognized as a promising target for the development of new drugs, as proved by the growing number of PPI modulators reaching clinical trials. In this context, peptides represent a valid alternative to small molecules, owing to their unique ability to mimic the target protein structure and interact with wider surface areas. Among the possible fields of interest, bacterial PPIs represent an attractive target to face the urgent necessity to fight antibiotic resistance.

Strong Casimir-like Forces in Flocking Active Matter.

Confining in space the equilibrium fluctuations of statistical systems with long-range correlations is known to result into effective forces on the boundaries. Here we demonstrate the occurrence of Casimir-like forces in the nonequilibrium context provided by flocking active matter. In particular, we consider a system of aligning self-propelled particles in two spatial dimensions that are transversally confined by reflecting or partially reflecting walls.

COVID-19 detection from exhaled breath.

The SARS-CoV-2 coronavirus emerged in 2019 causing a COVID-19 pandemic that resulted in 7 million deaths out of 770 million reported cases over the next 4 years. The global health emergency called for unprecedented efforts to monitor and reduce the rate of infection, pushing the study of new diagnostic methods. In this paper, we introduce a cheap, fast, and non-invasive COVID-19 detection system, which exploits only exhaled breath.

Exploring run-and-tumble movement in confined settings through simulation.

Motion in bounded domains is a fundamental concept in various fields, including billiard dynamics and random walks on finite lattices, and has important applications in physics, ecology, and biology. An important universal property related to the average return time to the boundary, the Mean Path Length Theorem (MPLT), has been proposed theoretically and experimentally confirmed in various contexts. We investigated a wide range of mechanisms that lead to deviations from this universal behavior, such as boundary effects, reorientation, and memory processes.

A Critical Appraisal of Reporting in Randomized Controlled Trials Investigating Osteopathic Manipulative Treatment: A Meta-Research Study.

: In osteopathy, it becomes necessary to produce high-quality evidence to demonstrate its effectiveness. The aim of this meta-research study is to assess the reporting quality of RCTs published in the osteopathic field. : The protocol was preliminarily registered on the "Open Science Framework (OSF)" website.

Nonsurgical removal of a massive calcification of the shoulder.

Calcific tendinopathy of the shoulder is a prevalent and painful condition marked by calcific deposits in the rotator cuff tendons or subacromial bursa, with an incidence of 2.7% to 20%, predominantly affecting individuals aged 30 to 50. Women are 1.

Non-recurrent Laryngeal Nerve During Intraoperative Neuromonitoring Thyroidectomy: A Case Report and Literature Review.

Complete and precise knowledge of the neck anatomy and its eventual anomalies is crucial while performing a safe thyroid and parathyroid surgery. Embryo-genetic malformations of the IV branchial arch can lead to an uncommon anatomical alteration known as non-recurrent inferior laryngeal nerve. Its prevalence varies between 0.

Temperature-dependent photoluminescence down to 77 K of organotin molecular rotors: eco-friendly synthesis, photophysical characterization, X-ray structures, and DFT studies.

Fluorescent organotin compounds are useful in sensing, optoelectronic devices, and bioimaging. Although fluorescence bioimaging shows low resolution at room temperature, a better resolution is possible at cryotemperatures. Therefore, the search for new cryoluminescent materials with potential application in high-resolution fluorescence bioimaging remains a great challenge.

COVID-19 could accelerate the decline in recreational hunting: A natural experiment from Northern Italy.

Although many studies highlighted the potential of COVID-19 to reshape existing models of wildlife management, empirical research on this topic has been scarce, particularly in Europe. We investigated the potential of COVID-19 pandemic to accelerate the ongoing decline in an aging population of recreational hunters in Italy. Namely, we modelled spatiotemporal trends between 2011 and 2021 in the number of recreational hunters in 50 Italian provinces with a varying incidence of COVID-19, and temporally delayed waves of infection.

Hysteroscopy: where did we start, and where are we now? The compelling story of what many considered the "Cinderella" of gynecological endoscopy.

Hysteroscopy has truly revolutionized the field of diagnostic and operative gynecology. It is presently regarded as the gold standard method for both the diagnosis and treatment of intrauterine diseases and it has fundamentally altered the way gynecologists treat patients with such conditions. These pathologies can now be diagnosed and treated in an outpatient setting, thanks to technological advancements and instrument downsizing.

Intrinsic dimension as a multi-scale summary statistics in network modeling.

Complex networks are powerful mathematical tools for modelling and understanding the behaviour of highly interconnected systems. However, existing methods for analyzing these networks focus on local properties (e.g.

Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy.

Hyaluronan (HA) has gained significant attention in cancer research for its role in modulating chemoresistance. This review aims to elucidate the mechanisms by which HA contributes to chemoresistance, focusing on its interactions within the tumor microenvironment. HA is abundantly present in the extracellular matrix (ECM) and binds to cell-surface receptors such as CD44 and RHAMM.

Decreased free D-aspartate levels in the blood serum of patients with schizophrenia.

Introduction: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental diseases characterized by different psychopathological manifestations and divergent clinical trajectories. Various alterations at glutamatergic synapses have been reported in both disorders, including abnormal NMDA and metabotropic receptor signaling.

Methods: We conducted a bicentric study to assess the blood serum levels of NMDA receptors-related glutamatergic amino acids and their precursors, including L-glutamate, L-glutamine, D-aspartate, L-aspartate, L-asparagine, D-serine, L-serine and glycine, in ASD, SCZ patients and their respective control subjects.

Diastereoselective Palladaelectro-Catalyzed Construction of Bromomethyl Morpholines as Key Step To Access Morpholino Homonucleosides.

A synthetic protocol for the preparation of a new class of morpholino homonucleosides in enantiopure form starting from readily available 1,2-aminoalcohols or glycidol has been developed. Key intermediates of the synthetic sequence are 2-bromomethyl morpholines, diastereoselectively achieved from the corresponding alkenols by palladaelectro-catalyzed alkoxybromination of unactivated alkenes. The so obtained bromo derivatives are in turn susceptible to functionalization with nucleic bases for easy access to morpholino homonucleosides.