Red Orange and Bitter Orange IntegroPectin: Structure and Main Functional Compounds.

DRIFT, HPLC-MS, and SPME-GC/MS analyses were used to unveil the structure and the main functional compounds of red (blood) orange () and bitter orange (). The IntegroPectin samples show evidence that these new citrus pectins are comprised of pectin rich in RG-I hairy regions functionalized with citrus biophenols, chiefly flavonoids and volatile molecules, mostly terpenes. Remarkably, IntegroPectin from the peel of fresh bitter oranges is the first high methoxyl citrus pectin extracted via hydrodynamic cavitation, whereas the red orange IntegroPectin is a low methoxyl pectin.

How Important Are Genes to Achieve Longevity?

Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE and FOXO3A, involved in the protection of cardiovascular diseases, have been shown to be associated with longevity in nearly all studies. This happens because the genetic determinants of longevity are dynamic and depend on the environmental history of a given population.

The chemical composition of essential oil from subsp. and subsp. (Apiaceae) aerial parts growing in Sicily (Italy).

L. genus, belonging to the Apiaceae family, includes more than eighty taxa, mainly growing in Europe and Asia. Due to the several biological properties, species of this genus have been largely investigated, showing to be a rich source of coumarins, as well as, of essential oils with anti-inflammatory, antiviral, antifungal, cytotoxic, etc.

Activation of indistinguishability-based quantum coherence for enhanced metrological applications with particle statistics imprint.

SignificanceQuantum coherence has a fundamentally different origin for nonidentical and identical particles since for the latter a unique contribution exists due to indistinguishability. Here we experimentally show how to exploit, in a controllable fashion, the contribution to quantum coherence stemming from spatial indistinguishability. Our experiment also directly proves, on the same footing, the different role of particle statistics (bosons or fermions) in supplying coherence-enabled advantage for quantum metrology.

Antifouling Mortars for Underwater Restoration.

This research has focused on the assessment of the compositional features and mechanical and antifouling performances of two different mortars formulated for an underwater setting, and which contain Mg(OH) as an antifouling agent. Regarding the mechanical characterization, the uniaxial compressive strength and flexural strength were measured. The composition of the materials was explored by differential thermal/thermogravimetric analysis (DTA-TG), X-ray diffraction analysis (XRPD), and scanning electronic microscopy (SEM) coupled with EDS microanalysis.

A new ferulol derivative isolated from the aerial parts of (L.) Boiss. growing in Sicily (Italy).

(L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area being present in Crete, Greece, Albania, and probably in Macedonia.

Asn25 Deamidation as an Allosteric Tool to Increase IFNβ-1a Biological Activity.

Interferon beta (IFNβ) is a well-known cytokine, belonging to the type I family, that exerts antiviral, immunomodulatory, and antiproliferative activity. It has been reported that the artificially deamidated form of recombinant IFNβ-1a at Asn25 position shows an increased biological activity. As a deepening of the previous study, the molecular mechanism underlying this biological effect was investigated in this work by combining experimental and computational techniques.

Dynamic clock generator and memory mass device using a quantum ring driven by three-color laser fields.

We study the behaviour and applications of a quantum ring (QR) under a three-color laser field. In particular we study the emission of harmonics and their temporal evolution through wavelets. These results suggest the use of QR for three important applications: (1) generation of single short pulses, (2) creation of a variable clock generator, (3) a memory mass device through the angular momentum acquired by the electron.

Atmospheric Concentration of CO and PM at Salina, Stromboli, and Vulcano Islands (Italy): How Anthropogenic Sources, Ordinary Volcanic Activity and Unrests Affect Air Quality.

Geogenic and anthropogenic sources of atmospheric particulate and CO can lead to threats to human health in volcanic areas. Although the volcanic CO hazard is a topic frequently debated in the related scientific literature, space and time distribution of PM are poorly known. The results of combined CO/PM surveys, carried out at Salina, Stromboli, and Vulcano islands (Aeolian archipelago, Italy) in the years 2020-2021, and integrated with investigations on bioaccumulation of metallic particulate matter by the mean of data on the magnetic properties of oleander leaves, are presented in this work.

Resting State EEG Directed Functional Connectivity Unveils Changes in Motor Network Organization in Subacute Stroke Patients After Rehabilitation.

Brain plasticity and functional reorganization are mechanisms behind functional motor recovery of patients after an ischemic stroke. The study of resting-state motor network functional connectivity by means of EEG proved to be useful in investigating changes occurring in the information flow and find correlation with motor function recovery. In the literature, most studies applying EEG to post-stroke patients investigated the undirected functional connectivity of interacting brain regions.

Genome-wide survey on three local horse populations with a focus on runs of homozygosity pattern.

Purosangue Orientale Siciliano, Sanfratellano and Siciliano represent the Sicilian equine genetic resource. This study aimed to investigate the genetic diversity, population structure and the pattern of autozygosity of Sicilian horse populations using genome-wide single-nucleotide polymorphism (SNP) data generated with the Illumina Equine SNP70 array. The genotyping data of 17 European and Middle East populations were also included in the study.

Archaeometric study of execution techniques of white Attic vases: the case of the Perseus crater in Agrigento.

The white ground crater by the Phiale Painter (450-440 BC) exhibited in the "Pietro Griffo" Archaeological Museum in Agrigento (Italy) depicts two scenes from Perseus myth. The vase is of utmost importance to archaeologists because the figures are drawn on a white background with remarkable daintiness and attention to detail. Notwithstanding the white ground ceramics being well documented from an archaeological and historical point of view, doubts concerning the compositions of pigments and binders and the production technique are still unsolved.

Rare ATG7 genetic variants predispose patients to severe fatty liver disease.

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disorders and has a strong heritable component. The aim of this study was to identify new loci that contribute to severe NAFLD by examining rare variants.

Methods: We performed whole-exome sequencing in individuals with NAFLD and advanced fibrosis or hepatocellular carcinoma (n = 301) and examined the enrichment of likely pathogenic rare variants vs.

Nurses' perception of the oncology patient's death: a qualitative study.

Background: Death is one of the basic theme with which nurses are faced, and for which it is hard for them to prepare deeply and sincerely. The difficulties in handling the emotional burden can cause them to develop negative feelings towards life and clinical practice, so that it affects their caregiving capacity and the quality of care provided.

Aim: To explore nurses' perceptions facing the death of a hospitalized oncology patient.

The essential oil compositions of three Sicilian accessions of L. growing on three different host trees.

L., (Common Mistletoe), is a hemiparasitic shrub that lives on a wide range of woody plant species, known since Neolithic period for its ritual and for pharmacological properties. Up to now, no investigation has been reported on the chemical composition of the essential oils of aerial parts in relation with the diverse host trees.

The chemical composition of essential oil from (Apiaceae) aerial parts growing in Sicily (Italy).

is a large genus of aromatic and economically important herbs of the Apiaceae family that includes eighty-seven taxa, mainly distributed in Europe and Asia. Several species of this genus are extensively used in various popular medicines and based on their traditional uses, much research concerning biological activities have been carried out. In the present study, the chemical composition of the essential oil from aerial parts of Guss.

Memory Effects in High-Dimensional Systems Faithfully Identified by Hilbert-Schmidt Speed-Based Witness.

A witness of non-Markovianity based on the Hilbert-Schmidt speed (HSS), a special type of quantum statistical speed, has been recently introduced for low-dimensional quantum systems. Such a non-Markovianity witness is particularly useful, being easily computable since no diagonalization of the system density matrix is required. We investigate the sensitivity of this HSS-based witness to detect non-Markovianity in various high-dimensional and multipartite open quantum systems with finite Hilbert spaces.

A dynamic air-liquid interface system for in vitro mimicking of the nasal mucosa.

The development of an in vitro 3D model for the growth of the nasal mucosa cells can improve the therapy and the study of pathological states for subjects with chronic airway conditions. We have previously characterized a system consisting of a scaffold with an internal channel and a perfusion bioreactor with two independent flows provided by an external and an internal circuit, respectively. In this paper, this system was designed as a model of the nasal cavity, in which cells, grown on the inner surface of the scaffold channel, would be in contact at the same time with both culture medium, supplied by the external circuit, and air, provided with the internal flow.

Mary Shelley's migraines and fatal stroke: some observations on their primary cause.

In this article the origins of Mary Shelley's neurological and cerebrovascular problems are described. Through a reanalysis of her biography, her early health issues caused by a dermatological condition, potentially eczema, psoriasis or chickenpox, are related, thanks to current biomedical knowledge, to her migraines and strokes, including the one that killed her.

The chemical composition of the aerial parts essential oil of Heldr. (Lamiaceae) growing in Kythira island (Greece).

is a large genus of economically important plants belonging to Lamiaceae family that includes about 300 species as annual or perennial herbs. Several species of this genus are extensively used in various traditional medicines. In the present study the chemical composition of the essential oil from aerial parts of Heldr.

Environmental RNA outperforms eDNA metabarcoding in assessing impact of marine pollution: A chromium-spiked mesocosm test.

Environmental (e)DNA metabarcoding holds great promise for biomonitoring and ecotoxicological applications. However, few studies have compared the performance of eDNA versus eRNA metabarcoding in assessing organismal response to marine pollution, in experimental conditions. Here, we performed a chromium (Cr)-spiked mesocosm experimental test on benthic foraminiferal community to investigate the effects on species diversity by analysing both eDNA and eRNA metabarcoding data across different Cr concentrations in the sediment.

Gender-specific soluble α-klotho levels as marker of GH deficiency in children: a case-control study.

Purpose: To evaluate circulating soluble α-klotho (sαKL) levels in GHD children before and after 12 months of GH treatment (GHT).

Methods: Auxological and basal metabolic parameters, oral glucose tolerance test for glucose and insulin levels, insulin sensitivity indices and klotho levels were evaluated before and after 12 months of follow-up in 58 GHD children and 56 healthy controls.

Results: At baseline, GHD children showed significantly lower growth velocity standard deviation score (SDS) (p < 0.

Chemical Compositions and Antioxidant Activities of Essential Oils, and Their Combinations, Obtained from Flavedo By-Product of Seven Cultivars of Sicilian L.

In this work, seven essential oils (EOs) derived from flavedo of cultivars 'Canaliculata', 'Consolei', 'Crispifolia', 'Fasciata', 'Foetifera', 'Listata', and 'Bizzaria' were investigated. EOs were also combined in 1:1 (/) ratio to identify possible synergism or antagonism of actions. GC-MS analysis was done to investigate Eos' phytochemical profiles.

Haemolymphatic Parameters in Two Aquaculture Crustacean Species (Clark, 1836) and (Von Martens, 1868).

In the last few years, there has been a notable development in the breeding of freshwater shrimp (astaciculture), which involved various species and in particular, the two Australian species, and . Information about the haemolymphatic parameters of these two species is fragmentary, and filling these gaps becomes important given their importance in aquaculture. Cellular and biochemical parameters were analyzed in both species to create a reference baseline for these parameters to identify the state of welfare or suffering of these animals.