1,691 results match your criteria: "Universita' di Siena[Affiliation]"

In an era of escalating environmental challenges, converting organic residues into high-value bioactive compounds provides a sustainable way to reduce waste and enhance resource efficiency. This study explores the potential of the circular bioeconomy through the valorization of agricultural byproducts, with a focus on the antioxidant properties of specific chestnut burr cultivars. Currently, over one-third of food production is wasted, contributing to both humanitarian and environmental crises.

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The Uluzzian and Châtelperronian: No Technological Affinity in a Shared Chronological Framework.

J Paleolit Archaeol

January 2025

Human Origins Research Unit, Faculty of Archaeology, Leiden University, Einsteinweg 2, 2333 CC Leiden, The Netherlands.

Unlabelled: The Châtelperronian and Uluzzian techno-complexes are identified in western Europe in the same stratigraphic position, between the late Middle Palaeolithic and other Upper Palaeolithic assemblages. Both industries include retouched artefacts with abrupt retouch and arched backs, and radiometric dating indicates that these two technocomplexes belong to the same window of time. Here, we provide a detailed, qualitative technological comparison of two Châtelperronian and two Uluzzian lithic assemblages based on a collaborative, first-hand examination of these collections.

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Photoswitches are widely investigated molecules because upon exposure to selected light irradiation, they are able to undergo structural, and hence optical, changes. To fully exploit their responsiveness to irradiation, the quantum efficiency of the forward and back reactions is a fundamental parameter, whose accurate determination is critical. In this work, the spectral evolution of a biomimetic switch, which undergoes / photoinduced isomerization, is spectrophotometrically examined.

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Early human collective practices and symbolism in the Early Upper Paleolithic of Southwest Asia.

Proc Natl Acad Sci U S A

December 2024

The Shmunis Family Anthropology Institute, Dan David Center for Human Evolution and Biohistory Research, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Article Synopsis
  • Identifying Paleolithic communal rituals helps understand group identity and cohesion.
  • Evidence shows that collective rituals took place in Manot Cave during the Early Upper Paleolithic, centered around an engraved boulder resembling a tortoise.
  • Analyses of artifacts and cave acoustics indicate fire was used for illumination, and the site was ideal for gatherings, stressing its role in social networking among EUP communities.
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  • The CMS experiment conducted a search for charge-parity violation in decays using proton-proton collision data from 2018, analyzing around 10 billion events with b hadrons decaying into charm hadrons.
  • The flavor of the neutral D meson was determined through the charge of pions in the reconstructed decays, and an asymmetry measurement in the decays was reported, taking into account various uncertainties.
  • This research marks the first asymmetry measurement by the CMS in the charm sector and the first to use a fully hadronic final state in such analyses.
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  • - Tumour angiogenesis is crucial for supplying malignant cells with oxygen and nutrients, facilitating their invasion and spread, often resulting in the formation of disorganized and leaky blood vessels due to cytokine activity.
  • - Nicotinamide phosphoribosyltransferase (eNAMPT) is elevated in many cancers, acting not only as a necessary enzyme for energy production but also as a pro-inflammatory cytokine that correlates with cancer aggressiveness and prognosis, especially in breast cancer.
  • - In triple-negative breast cancer, eNAMPT promotes angiogenesis and metastasis by attracting NG2 pericytes and activating pro-inflammatory signaling, with potential therapeutic effects demonstrated by neutralizing eNAMPT with an antibody, pointing towards new anti-
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Archaerhodopsin-3 (AR-3) variants stand out among other rhodopsins in that they display a weak, but voltage-sensitive, near-infrared fluorescence emission. This has led to their application in optogenetics both in cell cultures and small animals. However, in the context of improving the fluorescence characteristics of the next generation of AR-3 reporters, an understanding of their ultrafast light-response in light-adapted conditions, is mandatory.

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  • The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
  • A special data scouting method is utilized to pick out events with low combined momentum in jets.
  • This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
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Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis.

Cell Host Microbe

December 2024

IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan 20089, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan 20072, Italy. Electronic address:

Article Synopsis
  • ! Antibiotics are given to 20%-30% of pregnant women, yet their impact on newborn immune development is not well understood, leading to increased susceptibility to sepsis in offspring of treated mothers.
  • ! Newborn mice from antibiotic-treated mothers showed lower levels of immunoglobulin A (IgA) in breast milk and feces, leading to a weakened gut immune response and increased risks of gut bacteria entering the bloodstream.
  • ! Restoring IgA production through treatments or using breast milk from untreated mothers improved immune profiles and offered protection against sepsis in pups, emphasizing the importance of breastfeeding in mitigating antibiotic effects.
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The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics.

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Synthesis of β-lactam-zidovudine pronucleosides as potential selective narrow-spectrum antibacterial agents.

Org Biomol Chem

January 2025

Institut des Biomolécules Max Mousseron, Univ Montpellier, CNRS, ENSCM, Montpellier, France.

Since the discovery of penicillin, the forerunner of the most widely used class of antibiotics ( β-lactams), natural compounds and their derivatives represented a major source of antibacterial therapeutic products whose availability enabled modern medical practices (invasive surgery, organ transplant, .). However, the relentless emergence of resistant bacteria is challenging the long-term efficacy of antibiotics, also decreasing their economic attractiveness for big pharma, leading to a significant decay in antibacterial development in the 21 century and an increased use of last-resort drugs such as carbapenems or colistin.

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Uptake of Magnetite Nanoparticles on Polydopamine Films Deposited on Gold Surfaces: A Study by AFM and XPS.

Nanomaterials (Basel)

October 2024

ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Casaccia Research Centre, 00124 Rome, Italy.

Polydopamine has the capacity to adhere to a large variety of materials and this property offers the possibility to bind nanoparticles to solid surfaces. In this work, magnetite nanoparticles were deposited on gold substrates coated with polydopamine films. The aim of this work was to investigate the effects of the composition and morphology of the PDA layers on the sticking of magnetite nanoparticles.

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Correction to: Spinocerebellar ataxia 27B: a frequent and slowly progressive autosomal-dominant cerebellar ataxia-experience from an Italian cohort.

J Neurol

December 2024

Molecular Medicine for Neurodegenerative and Neuromuscular Diseases Unit, IRCCS Fondazione Stella Maris, via dei Giacinti 2, Calambrone, 56128, Pisa, Italy.

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Even though agriculture already spread into Eurasia during the Neolithic, the transition between the Copper Age and the Bronze Age was the time where Italian communities tuned horticultural techniques to foster the soil productivity. Carbon and nitrogen stable isotope analyses could be leveraged to identify some of those practices, such as manuring and irrigation. The former could spike the nitrogen values of plants, while water availability affects the carbon values.

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The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

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Multiproxy quantitative paleoceanographic dataset from late Quaternary marine sediment archives in the western Ross Sea (Antarctica).

Data Brief

December 2024

Consiglio Nazionale delle Ricerche (CNR)-Istituto di Scienze Marine - ISMAR, Via P. Gobetti, 101, Bologna, Italy.

The past ice sheet dynamics and the timing of retreat events in the paleo-record in the Ross Sea is an issue still few understood. In order to contribute to this topic, we provide a multiproxy data from marine sediment archives (cores and box cores) collected in three sites in the Central Basin (Western Ross Sea, Antarctica). Each site recorded different environments, affected by different oceanographic conditions and sedimentary regime.

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Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

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A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

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Article Synopsis
  • Alkaptonuria (AKU) is a hereditary metabolic disorder that primarily affects cartilage, leading to early osteoarthritis due to a process called ochronosis.
  • Researchers faced challenges in studying AKU using human chondrocytes but overcame this by creating an in vitro model using immortalized C20/A4 cells treated with homogentisic acid (HGA), mimicking AKU conditions.
  • This model revealed important insights, including oxidative stress and inflammatory responses linked to AKU, as well as potential amyloid fibril formation, highlighting its usefulness for understanding the disease and aiding in drug development.
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Optimization of the Pixel Design for Large Gamma Cameras Based on Silicon Photomultipliers.

Sensors (Basel)

September 2024

Departament de Física Quàntica i Astrofísica (FQA), Universitat de Barcelona (UB), 08028 Barcelona, Spain.

Most single-photon emission computed tomography (SPECT) scanners employ a gamma camera with a large scintillator crystal and 50-100 large photomultiplier tubes (PMTs). In the past, we proposed that the weight, size and cost of a scanner could be reduced by replacing the PMTs with large-area silicon photomultiplier (SiPM) pixels in which commercial SiPMs are summed to reduce the number of readout channels. We studied the feasibility of that solution with a small homemade camera, but the question on how it could be implemented in a large camera remained open.

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  • Repurposing saffron waste offers a sustainable way to create valuable products, as discarding flower components results in a large amount of waste—350 kg of tepals for every kg of stigmas.
  • This research utilized bioactivity studies and Life Cycle Assessments to analyze the beneficial compounds found in saffron tepals from Tuscany, discovering various flavonoids and their ability to reduce oxidative stress and enhance fermentation processes in yeast.
  • The findings also indicated significant anti-inflammatory properties and potential applications in pharmaceuticals and cosmetics, while highlighting the environmental benefits of such a "green" approach in supporting the circular bioeconomy.
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  • Demand for computing power in major scientific experiments, like the CMS at CERN, is expected to significantly increase over the coming decades.
  • The implementation of coprocessors, particularly GPUs, in data processing workflows can enhance performance and efficiency, especially for machine learning tasks.
  • The Services for Optimized Network Inference on Coprocessors (SONIC) approach allows for improved use of coprocessors, demonstrating successful integration and acceleration of workflows across various environments without sacrificing throughput.
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Energy correlators that describe energy-weighted distances between two or three particles in a hadronic jet are measured using an event sample of sqrt[s]=13  TeV proton-proton collisions collected by the CMS experiment and corresponding to an integrated luminosity of 36.3  fb^{-1}. The measured distributions are consistent with the trends in the simulation that reveal two key features of the strong interaction: confinement and asymptotic freedom.

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A measurement is presented of a ratio observable that provides a measure of the azimuthal correlations among jets with large transverse momentum . This observable is measured in multijet events over the range of - based on data collected by the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 , corresponding to an integrated luminosity of 134 . The results are compared with predictions from Monte Carlo parton-shower event generator simulations, as well as with fixed-order perturbative quantum chromodynamics (pQCD) predictions at next-to-leading-order (NLO) accuracy obtained with different parton distribution functions (PDFs) and corrected for nonperturbative and electroweak effects.

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