6,537 results match your criteria: "Universita' di Milano[Affiliation]"

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5  cm×5  cm×5  cm TeO_{2} crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in ^{130}Te. Unprecedented in size among cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic throughgoing particles. Using the first tonne year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various standard model extensions and would have suppressed interactions with matter.

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The warm Western Boundary Currents (WBCs) and their zonal extensions are persistent, deep, strong and narrow oceanic currents. They are known to anchor and energize the Extra-Tropical storm tracks by frontal thermal air-sea interactions. However, even in the latest generation of climate models, WBCs are characterized by large biases, and both the present storm-track activity and its recent intensification are poorly estimated.

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Article Synopsis
  • The CMS experiment conducted a search for charge-parity violation in decays using proton-proton collision data from 2018, analyzing around 10 billion events with b hadrons decaying into charm hadrons.
  • The flavor of the neutral D meson was determined through the charge of pions in the reconstructed decays, and an asymmetry measurement in the decays was reported, taking into account various uncertainties.
  • This research marks the first asymmetry measurement by the CMS in the charm sector and the first to use a fully hadronic final state in such analyses.
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The projected sensitivity of the effective electron neutrino-mass measurement with the KATRIN experiment is below 0.3 eV (90 % CL) after 5 years of data acquisition. The sensitivity is affected by the increased rate of the background electrons from KATRIN's main spectrometer.

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Aims: Interest in the well-being of professionals working in psychiatric patient care contexts is growing in the literature. The aim of this study was to explore the perceived role and work experience of psychologist psychotherapists working in Mental Health Centers (MHC).

Methods: A qualitative research was conducted involving psychologists with a training in psychotherapy working in Lombardy who had at least 3 months of working experience in a MHC.

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Article Synopsis
  • The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
  • A special data scouting method is utilized to pick out events with low combined momentum in jets.
  • This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
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  • RNA binding proteins (RBPs) are essential for gene regulation by recognizing specific RNA targets, and various methods exist to study their binding preferences, like CLIP and SELEX.
  • Current methods face challenges such as the need for purified proteins and extensive sequencing, which can limit their usage.
  • The proposed RNA bind-n-seq method simplifies the process by using random RNA pools and allows for multiple selection rounds, improving motif identification without needing recombinant proteins.
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Improved glycemic and weight control with Dulaglutide addition in SGLT2 inhibitor treated obese type 2 diabetic patients at high cardiovascular risk in a real-world setting. The AWARE-2 study.

Pharmacol Res

December 2024

Departmental Unit of Diabetes and Metabolism, San Paolo Hospital, ASST Santi Paolo e Carlo, Milan, Italy; Endocrinology and Metabolism, Department of Health Science, Università degli Studi di Milano, Milan, Italy. Electronic address:

We evaluated the effects on glycemic control and body weight of a GLP1-RA in obese type 2 diabetic patients treated with SGLT2-inhibitors and other hypoglycemic agents and/or insulin, in a real-world setting. A cohort of 583 type 2 diabetic outpatients treated with a SGLT2 inhibitor and/or other anti-diabetic medications were examined. Because patients had suboptimal glycemic control, the GLP1-RA Dulaglutide was added to ongoing medications.

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  • A study was conducted to evaluate the performance of a new glucose monitoring device called Glunovo Flash in patients with type 1 diabetes (T1D) who are already using continuous glucose monitoring (CGM) systems.
  • 45 patients participated, wearing both the Glunovo Flash and their usual CGM for two weeks, and the results showed that the Glunovo Flash led to a significantly higher Time In Range compared to other intermittently scanned CGMs, while other metrics remained similar.
  • Overall, patients reported a positive experience with the Glunovo Flash, though some aspects of the device could be improved for better user satisfaction.
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How Eyelid Changes May Impact on Tears.

J Clin Med

November 2024

Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.

This article examines the impact of eyelid margin diseases on tear film composition and associated ocular surface disorders. It highlights the prevalence of blepharitis and meibomian gland dysfunction, discussing risk factors and diagnostic considerations. Various therapeutic approaches, including eyelid hygiene, antibiotics, and innovative treatments, are explored.

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Pediatric Cranial Vault Lesions: A Tailored Approach According to Bony Involvement.

Children (Basel)

November 2024

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.

Background: Cranial vault lesions are common in children, with dermoid and epidermoid cysts being the most frequent. Management is debated due to their slow growth, but early resection can prevent complications and provide a definitive histological diagnosis, which is sometimes linked to systemic diseases.

Methods: A retrospective study of children treated surgically for cranial vault tumors from January 2011 to April 2023 was conducted.

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The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics.

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MXene Manipulating the Electronic and Photoelectric Properties of a Fullerene-Layered Heterojunction.

J Phys Chem Lett

December 2024

State Key Laboratory of Structural Analysis for Industrial Equipment & School of Physics, Dalian University of Technology, Dalian, Liaoning 116024 People's Republic of China.

An in-depth study of the substrate effect is crucial for optimizing and designing the performance of two-dimensional (2D) materials in practical applications. Fullerene monolayers (FMs), a new pure carbon system successfully prepared recently, have prompted renewed interest in the question of whether FMs might be exploited to create carbon-based functional materials with improved performance. Here, the electronic structure of a MXene-supported FM was investigated by first-principles calculations.

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Background And Aims: The role of vascular smooth muscle cells (SMCs) in atherosclerosis has evolved to indicate causal genetic links with the disease. Single cell RNA sequencing (scRNAseq) studies have identified multiple cell populations of mesenchymal origin within atherosclerotic lesions, including various SMC sub-phenotypes, but it is unknown how they relate to patient clinical parameters and genetics. Here, mesenchymal cell populations in atherosclerotic plaques were correlated with major coronary artery disease (CAD) genetic variants and functional analyses performed to identify SMC markers involved in the disease.

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Background: The global demographic shift towards an aging population is generating a rise in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent problem. In this landscape, the use of natural supplements has garnered attention for their potential in dementia prevention. Curcumin (Cur), derived from Curcuma longa, has demonstrated promising pharmacological effects against AD by reducing the levels of inflammatory mediators.

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Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry.

Joint Bone Spine

November 2024

Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy. Electronic address:

Article Synopsis
  • The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
  • A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
  • Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
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In June 2024, WHO released 'Key updates to the treatment of drug-resistant tuberculosis: rapid communication', after the preliminary publication of results from two clinical trials: 'BEAT-Tuberculosis' and 'endTB'. All proposed regimens include clofazimine (Cfz). However, a recent paper has reported a high incidence of QTc prolongation among patients receiving Cfz-based treatment for multidrug-resistant TB in Taiwan.

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  • A systematic review examined left atrial mechanics in patients with atrial fibrillation (AF) about to undergo electrical cardioversion (ECV), focusing on the effect of AF on left atrial reservoir strain (LASr).
  • The analysis included 12 studies with a total of 880 patients, revealing a high ECV success rate of 91.5%, but highlighted that 35.2% of patients experienced AF recurrence within a median follow-up of 5.4 months.
  • Key findings indicated that a lower LASr before ECV was linked to higher chances of cardioversion failure and AF recurrence, suggesting that measuring LASr could help predict AF relapse and assess thromboembolic risk in these patients. *
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Scalable bottom-up synthesis of Co-Ni-doped graphene.

Sci Adv

November 2024

CNR-Istituto Officina dei Materiali (IOM), Strada Statale 14, km 163.5, 34149 Trieste, Italy.

Introducing heteroatoms into graphene is a powerful strategy to modulate its catalytic, electronic, and magnetic properties. At variance with the cases of nitrogen (N)- and boron (B)-doped graphene, a scalable method for incorporating transition metal atoms in the carbon (C) mesh is currently lacking, limiting the applicative interest of model system studies. This work presents a during-growth synthesis enabling the incorporation of cobalt (Co) alongside nickel (Ni) atoms in graphene on a Ni(111) substrate.

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  • The study investigates the use of Artificial Intelligence (AI) to assess liver fibrosis in patients with Metabolic-Associated Steatotic Hepatitis (MASH) more accurately than traditional methods.
  • Out of 60 patients, biopsies were analyzed using AI technology to measure features like collagen area and entropy, revealing significant differences across fibrosis stages and treatment responses.
  • Results showed that AI could identify changes in fibrosis in 76% of cases post-treatment, suggesting it offers a more reliable way to evaluate disease progression and treatment efficacy.
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Paroxetine, a selective serotonin reuptake inhibitor (SSRI), may induce sexual dysfunction during treatment and upon discontinuation. The mechanisms involved have been poorly explored so far. We have analyzed, by RNA sequencing, the whole transcriptomic profile in the hypothalamus and nucleus accumbens (NAc) (two brain regions involved in sexual behavior) of male rats daily treated for 2 weeks with paroxetine (T0) and at 1 month of withdrawal (T1).

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A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

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The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

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Article Synopsis
  • - The ATLAS experiment at the LHC conducted a search for long-lived particles (LLPs) using a large dataset (140 fb^{-1}) from proton-proton collisions at 13 TeV, focusing on LLPs with masses from 5 to 55 GeV that decay within the inner detector.
  • - The study considered scenarios where LLPs are produced from exotic Higgs boson decays and models involving axionlike particles (ALPs).
  • - No significant findings above expected background levels were detected, leading to the establishment of upper limits on various production rates involving the Higgs boson and the top quark related to LLPs and ALPs.
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