224 results match your criteria: "Universita' degli Studi Milano-Bicocca[Affiliation]"

[Potassium role in the human body and clinical implications of hyperkalemia].

G Ital Cardiol (Rome)

January 2025

U.O.C. Cardiologia 1-Emodinamica, Dipartimento Cardiotoracovascolare "A. De Gasperis", ASST Grande Ospedale Metropolitano Niguarda, Milano.

Potassium is the most represented intracellular electrolyte in the human body. Its extracellular levels are maintained within strict limits through different mechanisms, which constitute the homeostasis of potassium. Hyperkalemia is the most common electrolyte disorder in patients with cardiovascular disease.

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Neutron detection is nowadays mostly based on He gas detectors, but its shortage and the continuous upgrades of the neutron facilities require new devices to perform experiments with maximum performances. This work presents a new detector based on the Gas Electron Multiplier (GEM) combined with several boron layers. This detector combines the features of GEM technology with the properties of boron as a neutron converter and the device is produced to sustain high neutron fluxes with high detection efficiency.

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While abundant literature suggests that both performing congruent actions and emotional stimuli can enhance memory, their combined impact on memory for action phrases remains underexplored. This study investigated the effects of enactment with emotionally charged stimuli on memory performance. Sixty participants encoded action sentences with negative, neutral, or positive emotional connotations using either enactment or verbal-reading methods.

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Article Synopsis
  • * Analyzed data from 7948 HF patients over a minimum of 2 years, employing topological data analysis (TDA) to find 19 patient clusters and trajectory analysis to outline disease evolution.
  • * Findings included a 5-year survival rate across clusters ranging from 20% to 100%, with strong validation results from external and internal cohorts, confirming the reliability of the identified patient pathways.
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Article Synopsis
  • PI4KA-related disorder is marked by a variety of neurological and gastrointestinal issues, including spasticity, developmental challenges, and recurrent infections, with specific attention given to the impact on B-cell function and immunodeficiency in some patients. * -
  • The study involved analyzing 13 patients with PI4KA variants, revealing common traits such as B-cell deficiency and hypogammaglobulinemia, alongside significant changes in B-cell subsets and functioning due to metabolic disruptions. * -
  • Findings indicate that mutations in PI4KA lead to disturbances in lipid production and metabolic pathways in B cells, fostering mitochondrial dysfunction and abnormal immune responses, suggesting a critical role of PI4KA in B-cell differentiation and health. *
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Optimizing leapover lengths of Lévy flights with resetting.

Phys Rev E

August 2024

Dipartimento di Matematica e Applicazioni, Università degli Studi Milano-Bicocca, 20126 Milan, Italy.

We consider a one-dimensional search process under stochastic resetting conditions. A target is located at b≥0 and a searcher, starting from the origin, performs a discrete-time random walk with independent jumps drawn from a heavy-tailed distribution. Before each jump, there is a given probability r of restarting the walk from the initial position.

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[Contemporary diagnosis and treatment of tricuspid regurgitation: from neglected valve to primetime].

G Ital Cardiol (Rome)

August 2024

Cardiologia Interventistica, Cardiologia I-Emodinamica, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milano.

Article Synopsis
  • Tricuspid insufficiency used to be thought of as not very important, but new research shows it actually plays a big role in causing problems with the right side of the heart.
  • New technology is making it possible to treat patients who were too risky for regular surgery, helping them feel better and live better lives.
  • The focus now is on getting patients the right care by sending them to specialized centers that know how to diagnose and treat this condition effectively.
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[Substance abuse and cardiovascular risk: energy drinks].

G Ital Cardiol (Rome)

August 2024

U.O.C. Cardiologia 1-Emodinamica, ASST Grande Ospedale Metropolitano Niguarda, Milano - Presidente, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), Firenze.

The consumption of energy drinks (ED) has become a growing public health issue, since potentially ED-related serious adverse cardiovascular events, including arrhythmias, myocardial infarction, cardiomyopathies, and sudden cardiac death, have been reported in recent years. The substances contained in ED include caffeine, taurine, sugars, B group vitamins and phyto-derivatives, which, especially if taken in large quantities and in a short amount of time, could cause serious side effects through various mechanisms of action, such as increased blood pressure and QT interval prolongation. Although there are still many open questions on ED that require further specific investigations, there is an urgent need for information and educational plans to the population, as well as for regulatory actions, particularly regarding transparency of substances and possible adverse effects.

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In recent years, there has been a noticeable increase in attention towards promoting well-being within academic settings. In the specific context of academia, a critical issue is understanding whether the current practices for assessing and managing well-being can bridge the implementation gap and increase opportunities for creating healthy academic conditions. The paper explores the practices adopted for assessing and managing work-related stress (WRS) risks in Italian academia by referring to data from a group of Italian universities of the QoL@Work network (Quality of Life at Work in academia).

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Embodied Spatial Navigation Training in Mild Cognitive Impairment: A Proof-of-Concept Trial.

J Alzheimers Dis

August 2024

Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Background: Egocentric and allocentric spatial memory impairments affect the navigation abilities of older adults with mild cognitive impairment (MCI). Embodied cognition research hints that specific aids can be implemented into virtual reality (VR) training to enhance spatial memory.

Objective: In this study, we preliminarily tested 'ANTaging', an embodied-based immersive VR training for egocentric and allocentric memory, compared to treatment as usual (TAU) spatial training in MCI.

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Fast emitting polymeric scintillators are requested in advanced applications where high speed detectors with a large signal-to-noise ratio are needed. However, their low density implies a weak stopping power of high energy radiation and thus a limited light output and sensitivity. To enhance their performance, polymeric scintillators can be loaded with dense nanoparticles (NPs).

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Previous research has demonstrated cognate translation priming effects in masked priming lexical decision tasks (LDTs) even when a bilingual's two languages have different scripts. Because those effect sizes are normally larger than with noncognates, the effects have been partially attributed to the impact of prime-target phonological similarity. The present research extended that work by examining priming effects when using triple different-script cognates, i.

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Bodily and Visual-Cognitive Navigation Aids to Enhance Spatial Recall in Mild Cognitive Impairment.

J Alzheimers Dis

May 2024

Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Background: Individuals with mild cognitive impairment (MCI) syndrome often report navigation difficulties, accompanied by impairments in egocentric and allocentric spatial memory. However, studies have shown that both bodily (e.g.

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CT Arthrography of the Elbow: What Radiologists Should Know.

Tomography

March 2024

IRCCS Istituto Ortopedico Galeazzi, Unità Operativa di Radiologia Diagnostica ed Interventistica, 20157 Milan, Italy.

Computed tomography (CT) arthrography is a quickly available imaging modality to investigate elbow disorders. Its excellent spatial resolution enables the detection of subtle pathologic changes of intra-articular structures, which makes this technique extremely valuable in a joint with very tiny chondral layers and complex anatomy of articular capsule and ligaments. Radiation exposure has been widely decreased with the novel CT scanners, thereby increasing the indications of this examination.

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Riboflavin-LSD1 axis participates in the in vivo tumor-associated macrophage morphology in human colorectal liver metastases.

Cancer Immunol Immunother

March 2024

Laboratory of Metabolites and Proteins in Translational Research, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.

Article Synopsis
  • - Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment, with smaller TAMs (S-TAMs) linked to better prognosis in colorectal liver metastasis compared to larger TAMs (L-TAMs).
  • - Research using multiparametric flow cytometry and metabolomics identified that L-TAMs show a strong association with riboflavin, which affects the enzyme lysine-specific demethylase 1A (LSD1) and plays a role in TAM morphology.
  • - The study suggests that targeting the riboflavin-LSD1 relationship could reprogram TAM subtypes, offering new strategies for anti-tumor therapies.
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Hemodynamic evaluation in preterm infants using ultrasonic cardiac output monitor (USCOM).

Eur J Pediatr

May 2024

Neonatal Intensive Care Unit, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900, Monza, MB, Italy.

We aimed to establish reference ranges for USCOM parameters in preterm infants, determine factors that affect cardiac output, and evaluate the measurement repeatability. This retro-prospective study was performed at Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. We included infants below 32 weeks of gestational age (GA) and/or 1500 g of birth weight (BW).

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Article Synopsis
  • Mutations in the CBP/p300 histone acetyltransferase (HAT) domain are linked to leukemia and affect leukocyte compartment sizes.
  • The small-molecule A485 was found to quickly mobilize leukocytes from bone marrow to blood, showing similar effectiveness as granulocyte colony-stimulating factor (G-CSF) but working through a different mechanism.
  • A485 activation of the HPA axis influences leukocyte distribution via specific hormones, suggesting a potential new approach for rapidly increasing blood leukocyte levels to help treat various human diseases.
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[Lipoprotein(a): relationships with atherosclerosis and valvular heart disease, and emerging therapies].

G Ital Cardiol (Rome)

February 2024

U.O.C. Cardiologia 1 - Emodinamica, Grande Ospedale Metropolitano Niguarda, Milano - Presidente Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), Firenze.

Lipoprotein(a) [Lp(a)] is a well-established cardiovascular risk factor, whose relationship with atherosclerotic disease has been confirmed by epidemiological, genome-wide association, Mendelian randomization, and meta-analysis studies. This association is determined by its pro-atherogenic, pro-thrombotic and pro-inflammatory properties. Lp(a) is the most common monogenic risk factor for atherosclerosis, with a prevalence of about 1 in 5 people.

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Article Synopsis
  • Immersive virtual reality (IVR) has educational benefits, especially from a constructivist perspective, and its integration with Metaverse platforms could revolutionize learning and collaboration.
  • A survey of 329 Italian undergraduate students used the Unified Theory of Acceptance and Use of Technology (UTAUT) to assess attitudes towards IVR in education, identifying key factors influencing adoption.
  • The study found that while UTAUT constructs like performance expectancy and social influence strongly predicted students' intention to use IVR, individual factors such as learning styles had a minimal impact, suggesting a need for awareness of stakeholders' attitudes towards this technology.
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A comparison of visual assessment and semi-quantification for the diagnostic and prognostic use of [F]flortaucipir PET in a memory clinic cohort.

Eur J Nucl Med Mol Imaging

May 2024

Diagnostic Department, Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.

Purpose: [F]Flortaucipir PET is a powerful diagnostic and prognostic tool for Alzheimer's disease (AD). Tau status definition is mainly based in the literature on semi-quantitative measures while in clinical settings visual assessment is usually preferred. We compared visual assessment with established semi-quantitative measures to classify subjects and predict the risk of cognitive decline in a memory clinic population.

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Late diagnosis and the lack of screening methods for early detection define high-grade serous ovarian cancer (HGSOC) as the gynecological malignancy with the highest mortality rate. In the work presented here, we investigated a retrospective and multicentric cohort of 250 archival Papanicolaou (Pap) test smears collected during routine gynecological screening. Samples were taken at different time points (from 1 month to 13.

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The effect of visual perspective on episodic memory in aging: A virtual reality study.

Conscious Cogn

November 2023

MySpace Lab, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), University of Lausanne, Lausanne, Switzerland.

The possibility of flexibly retrieving our memories using a first-person or a third-person perspective (1PP or 3PP) has been extensively investigated in episodic memory research. Here, we used a Virtual Reality-based paradigm to manipulate the visual perspective used during the encoding stage to investigate age-related differences in the formation of memories experienced from 1PP vs. 3PP.

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