Principles and mechanisms of regeneration in the mouse model for wound-induced hair follicle neogenesis.

Wound induced hair follicle neogenesis (WIHN) describes a regenerative phenomenon in adult mammalian skin, wherein fully functional hair follicles regenerate in the center of large excisional wounds. Originally described in rats, rabbits, sheep, and humans in 1940-60, the WIHN phenomenon was reinvestigated in mice only recently. The process of hair regeneration largely duplicates the morphological and signaling features of normal embryonic hair development.

A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications.

In this paper, the authors' review the applicability of the open-source GATE Monte Carlo simulation platform based on the GEANT4 toolkit for radiation therapy and dosimetry applications. The many applications of GATE for state-of-the-art radiotherapy simulations are described including external beam radiotherapy, brachytherapy, intraoperative radiotherapy, hadrontherapy, molecular radiotherapy, and in vivo dose monitoring. Investigations that have been performed using GEANT4 only are also mentioned to illustrate the potential of GATE.

PET-based dose delivery verification in proton therapy: a GATE based simulation study of five PET system designs in clinical conditions.

PET is a promising technique for in vivo treatment verification in hadrontherapy. Three main PET geometries dedicated to in-beam treatment monitoring have been proposed in the literature: the dual-head PET geometry, the OpenPET geometry and the slanted-closed ring geometry. The aim of this work is to characterize the performance of two of these dedicated PET detectors in realistic clinical conditions.

Distributions of secondary particles in proton and carbon-ion therapy: a comparison between GATE/Geant4 and FLUKA Monte Carlo codes.

Monte Carlo simulations play a crucial role for in-vivo treatment monitoring based on PET and prompt gamma imaging in proton and carbon-ion therapies. The accuracy of the nuclear fragmentation models implemented in these codes might affect the quality of the treatment verification. In this paper, we investigate the nuclear models implemented in GATE/Geant4 and FLUKA by comparing the angular and energy distributions of secondary particles exiting a homogeneous target of PMMA.