p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment.

Prostate cancer is a heterogeneous disease with a slow progression and a highly variable clinical outcome. The tumor suppressor genes PTEN and TP53 are frequently mutated in prostate cancer and are predictive of early metastatic dissemination and unfavorable patient outcomes. The progression of solid tumors to metastasis is often associated with increased cell plasticity, but the complex events underlying TP53-loss-induced disease aggressiveness remain incompletely understood.

Dual role of Xenopus Odf2 in multiciliated cell patterning and differentiation.

In developing tissues, the number, position, and differentiation of cells must be coordinately controlled to ensure the emergence of physiological function. The epidermis of the Xenopus embryo contains thousands of uniformly distributed multiciliated cells (MCCs), which grow hundreds of coordinately polarized cilia that beat vigorously to generate superficial water flow. Using this model, we uncovered a dual role for the conserved centriolar component Odf2, in MCC apical organization at the cell level, and in MCC spatial distribution at the tissue level.

Potential roles of mitochondrial carrier proteins in plant responses to abiotic stress.

The transport of metabolites across the inner mitochondrial membrane (IMM) is crucial for maintaining energy balance and efficient distribution of metabolic intermediates between cellular compartments. Under abiotic stress, mitochondrial function becomes particularly critical, activating complex signaling pathways essential for plant stress responses. These pathways modulate stress-responsive gene expression, influencing key physiological processes such as cell respiration and senescence, helping plants adapt to stress.

Immunonutrition to improve the quality of life of upper gastrointestinal cancer patients undergoing neoadjuvant treatment prior to surgery (NEOIMMUNE): double-blind randomized controlled multicenter clinical trial.

Background: Malnutrition is common with esophagogastric cancers and is associated with negative outcomes. We aimed to evaluate if immunonutrition during neoadjuvant treatment improves patient's health-related quality of life (HRQOL) and reduces postoperative morbidity and toxicities during neoadjuvant treatment.

Methods: A multicenter double-blind randomized controlled trial (RCT) was undertaken.

Identification of the conditions and minimum requirements necessary for the release of autologous fresh CAR T-cell products under hospital exemption: a position paper from the WP-bioproduction of the UNITC consortium.

The accessibility of CAR-T cells in centralized production models faces significant challenges, primarily stemming from logistical complexities and prohibitive costs. However, European Regulation EC No. 1394/2007 introduced a pivotal provision known as the hospital exemption.

Mathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics.

Telomere shortening ultimately causes replicative senescence. However, identifying the mechanisms driving replicative senescence in cell populations is challenging due to the heterogeneity of telomere lengths and the asynchrony of senescence onset. Here, we present a mathematical model of telomere shortening and replicative senescence in Saccharomyces cerevisiae which is quantitatively calibrated and validated using data of telomerase-deficient single cells.

An unexpected guest: First report of Tintelnotia destructans as an agent of maxillary fungus ball.

Fungal rhinosinusal infections comprise several nosological entities, including sinus fungus ball. Diagnosis of sinus fungus ball relies on patient interrogation and clinical and paraclinical findings. Mold species commonly involved include Aspergillus, as well as dematiaceous fungi.

Investigating the quality of European silver eels by quantifying contaminants and parasite infestation in a French Mediterranean lagoon complex.

Coastal lagoons are diverse habitats with significant ecological gradients, which provide crucial ecosystem services but face threats from human activities such as invasive species and pollution. Among the species inhabiting the lagoons, the critically endangered European eel (Anguilla anguilla) is an emblematic species strongly impacted by contamination and parasitism. Several indicators were developed to assess the quality of eel at a large geographic scale.

Functional carbohydrate-active enzymes acquired by horizontal gene transfer from plants in the whitefly Bemisia tabaci.

Carbohydrate-active enzymes (CAZymes) involved in the degradation of plant cell walls and/or the assimilation of plant carbohydrates for energy uptake are widely distributed in microorganisms. In contrast, they are less frequent in animals, although there are exceptions, including examples of CAZymes acquired by horizontal gene transfer (HGT) from bacteria or fungi in several of phytophagous arthropods and plant-parasitic nematodes. Although the whitefly Bemisia tabaci is a major agricultural pest, knowledge of HGT-acquired CAZymes in this phloem-feeding insect of the Hemiptera order (subfamily Aleyrodinae) is still lacking.

Furan-Indole-Chromenone-Based Organic Photocatalyst for α-Arylation of Enol Acetate and Free Radical Polymerization Under LED Irradiation.

In this study we report on the efficiency of a furane-indole-chromenone-based organic derivative () as a photocatalyst in the α-arylation of enol acetate upon LED irradiation at 405 nm, and as a photoinitiator/photocatalyst in the free radical polymerization of an acrylate group in the presence of -(4--butylphenyl)iodonium hexafluorophosphate (Iod) as an additive, or in the presence of both Iod and ethyl-4-(dimethyl amino) benzoate (EDB) under LED irradiation at 365 nm. The photochemical properties of this new light-sensitive compound are described, and the wide redox window (3.27 eV) and the high excited-state potentials / (+2.

Enhancing Radiation Therapy Response in Prostate Cancer Through Metabolic Modulation by Mito-Lonidamine: A H and P Magnetic Resonance Spectroscopy Study.

Radiation therapy (RT) is the cornerstone treatment for prostate cancer; however, it frequently induces gastrointestinal and genitourinary toxicities that substantially diminish the patients' quality of life. While many individuals experience transient side effects, a subset endures persistent, long-term complications. A promising strategy to mitigate these toxicities involves enhancing tumor radiosensitivity, potentially allowing for lower radiation doses.

The Expanding Universe of Extensions and Tails: Ribosomal Proteins and Histones in RNA and DNA Complex Signaling and Dynamics.

This short review bridges two biological fields: ribosomes and nucleosomes-two nucleoprotein assemblies that, along with many viruses, share proteins featuring long filamentous segments at their N- or C-termini. A central hypothesis is that these extensions and tails perform analogous functions in both systems. The evolution of these structures appears closely tied to the emergence of regulatory networks and signaling pathways, facilitating increasingly complex roles for ribosomes and nucleosome alike.

Evaluation of the Early Development of 6-Month-Old Babies in the Case of Maternal Postpartum Depression with or Without Bipolar Disorder.

Background: The first year of life is the period of greatest brain plasticity. Postpartum depression can adversely affect the first interactions with the child and, consequently, their emotional, social, and cognitive development.

Objectives: First, to describe the developmental profile of six-month-old infants of mothers suffering from severe postpartum depression, and, second, to compare the development of infants whose mothers suffer from depression with or without bipolar disorder.

Structural model of a bacterial focal adhesion complex.

Cell movement on surfaces relies on focal adhesion complexes (FAs), which connect cytoskeletal motors to the extracellular matrix to produce traction forces. The soil bacterium Myxococcus xanthus uses a bacterial FA (bFA), for surface movement and predation. The bFA system, known as Agl-Glt, is a complex network of at least 17 proteins spanning the cell envelope.

Sexual dimorphism of the humerus bones in a French sample: comparison of several statistical models including machine learning models.

Sex estimation is an important part of skeletal analysis and forensic identification. Traditionally pelvic traits are utilized for accurate sex estimation. However, the long bones, especially humerus, have been proved to be as effective for determine the sex of the individual.

Thermoelectric properties of a quantum dot attached to normal metal and topological superconductor.

The thermoelectric properties of hybrid systems based on a single-level quantum dot coupled to a normal-metal/half-metallic lead and attached to a topological superconductor wire are investigated. The topological superconductor wire is modeled by a spinless p-wave superconductor which hosts both a Majorana bound state at its extremity and above gap quasiparticle excitations. The main interest of our investigation is to study the interplay of sub-gap and single-particle tunneling processes and their contributions to the thermoelectric response of the considered system.

Breast imaging readers' performance in the PERFORMS test-set based assessment scheme within the MyPeBS international randomised study.

Purpose: A survey conducted by the European Society of Breast Imaging (EUSOBI) in 2023 revealed significant variations in Quality Assurance (QA) practices across Europe. The UK encourages regular performance monitoring for screen readers. This study aimed to assess the variability in diagnostic performance among readers participating in a wider prospective randomised trial across multiple countries.

Behavior and fate of ITER-like tungsten nanoparticles in freshwater ecosystems produced during operation and maintenance.

Within the ITER project (International Thermonuclear Experimental Reactor) an international project building a magnetic confinement device to achieve fusion as a sustainable energy source, tungsten (W) is planned to serve as a plasma-facing component (PFC) in the tokamak, a magnetic confinement device used to produce controlled thermonuclear fusion power. Post plasma-W interactions, submicron tungsten particles can be released. This study investigated the exposure of lentic freshwater ecosystems to ITER-like tungsten nanoparticles in indoor aquatic mesocosms.

Hydration of 3-Methyl-1,2,3-butanetricarboxylic Acid Evidenced by Matrix-Isolation Infrared Spectroscopy.

The hydration mechanism of 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA), a relevant marker of secondary organic aerosol formation from the atmospheric oxidation of α-pinene, has been investigated using the matrix-isolation infrared spectroscopy technique. The experimental results were supported by theoretical calculations. Monomers of MBTCA and heterocomplexes MBTCA-(HO) were identified.

Role of Heterogeneous Reactions in the Atmospheric Oxidizing Capacity in Island Environments.

The source of nitrous acid (HONO) and its importance in island or marine environments are poorly understood. Herein, based on comprehensive field measurements at a hilltop on Corsica Island, we find an inverse diel variation of HONO with higher concentrations during daytime. Night-time HONO budget analysis indicates significant HONO formation during air mass transport along the hillside.

Arthroscopic treatment of scaphoid nonunion with debridement and cancellous bone grafting before or after K-wire fixation.

We compared the outcomes of two groups of patients with scaphoid nonunion treated with arthroscopic cancellous bone grafting. In group 1, K-wires were introduced beforehand and in group 2 after debridement and packing bone grafts in the nonunion site. Our hypothesis was that the percentage of unions would be higher in group 2.