1 results match your criteria: "Universitätsstrasse 5 45141 Essen Germany shirley.knauer@uni-due.de.[Affiliation]"
Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand.
RSC Adv
November 2022
Molecular Biology II, Center of Medical Biotechnology (ZMB)/Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstrasse 5 45141 Essen Germany
Therapy resistance remains a challenge for the clinics. Here, dual-active chemicals that simultaneously inhibit independent functions in disease-relevant proteins are desired though highly challenging. As a model, we here addressed the unique protease threonine aspartase 1, involved in various cancers.
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