3 results match your criteria: "Universitätsklinikum Würzburg; Seif_M@ukw.de.[Affiliation]"

[Pneumococcal vaccine: protection of adults and reduction of antibiotic resistence by vaccination of children with a conjugated vaccine].

Med Monatsschr Pharm

June 2011

Sektion für Klinische Infektiologie, Abteilung für Gastroenterologie, Hepatologie und Infektiologie, Klinik für Innere Medizin II, Universitäatsklinikum Jena, Jena.

Article Synopsis
  • Pneumococcal infections, such as pneumonia and meningitis, commonly affect toddlers, the elderly, and those with weakened immune systems, with healthy toddlers acting as primary carriers of the bacteria in their nasopharynx.* -
  • There are two types of pneumococcal vaccines: the older polysaccharide vaccine, which offers limited immunity especially in children under two due to their immature immune systems, and a newer conjugate vaccine that effectively stimulates both T and B cell responses.* -
  • The introduction of the conjugate vaccine has led to significant reductions in pneumococcal disease rates through "herd protection," benefiting both vaccinated children and the broader population while also helping lower rates of antibiotic resistance.*
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Mechanical circulatory support and mechanical unloading of the left ventricle become more and more routine in clinical treatment regimens of both acute and chronic heart failure. Along with increasing availability of different cardiac assist systems one can adjust the degree of support according to the clinical situation. We report about our experience in the period between January 1994 and May 1995 with following assist systems: Hemopump, centrifugal pumps, Medos, HIAVAD and Novacor.

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Despite the fact that all the progress in technology, surgical technique and pathophysiological knowledge has made aortocoronary bypass surgery a safe routine procedure, there are certain clinical settings where an alternative approach seems to be advantageous. In 50 patients with age ranging from 51 to 74 years with advanced coronary heart disease and poor left ventricular (LV) function, as well as in patients with good LV function and single or double vessel disease not amenable for PTCA and in patients with acute ischemia or recent myocardial infarction, we performed coronary artery bypass grafting (CABG) without cardioplegic arrest during a short period of left ventricular unloading by means of a left ventricular assist device (LVAD). During LVAD support we administered Esmolol to decrease the heart rate and to keep the heart flaccid to facilitate easier peripheral anastomosis on a breathing heart.

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