[Anticoagulation and antiaggregation in pediatrics].

The hemostatic system consisting of primary and secondary hemostasis as well as fibrinolysis is an evolving process throughout life with important qualitative and quantitative differences between children and adults. Moreover, the different age groups of childhood differ in many aspects of their hemostatic system. These differences reflect an adaptation to the young age rather than immaturity.

[Single and double high-dose chemotherapy with autologous stem cell transplantation in children with advanced solid tumors: first experiences].

The disease-free survival of children with malignant disorders has increased impressively over the last three decades due to better understanding of tumour biology and the resultant improvement in diagnosis and therapy. Children with advanced and relapsed solid tumours, such as brain tumour, alveolar rhabdomyosarcoma, Ewing's sarcoma, or neuroblastoma, have not benefited from this progress. The concept of myeloablative high-dose chemotherapy (HDT) is based on the observation that certain cytostatic drugs have a steep linear dose-response curve, and thus escalating the dose may increase the tumour cell kill.