32,115 results match your criteria: "Universitätsfrauenklinik Giessen[Affiliation]"

Biological invasions are a major threat to biodiversity, ecosystem functioning and nature's contributions to people worldwide. However, the effectiveness of invasive alien species (IAS) management measures and the progress toward achieving biodiversity targets remain uncertain due to limited and nonuniform data availability. Management success is usually assessed at a local level and documented in technical reports, often written in languages other than English, which makes such data notoriously difficult to collect at large geographic scales.

View Article and Find Full Text PDF

Optogenetic therapy is a promising vision restoration method where light sensitive opsins are introduced to the surviving inner retina following photoreceptor degeneration. The cell type targeted for opsin expression will likely influence the quality of restored vision. However, a like-for-like pre-clinical comparison of visual responses evoked following equivalent opsin expression in the two major targets, ON bipolar (ON BCs) or retinal ganglion cells (RGCs), is absent.

View Article and Find Full Text PDF

Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome.

BMC Vet Res

January 2025

Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, D-35392, Giessen, Germany.

Background: The recently identified swine inflammation and necrosis syndrome (SINS) affects tail, ears, teats, coronary bands, claws and heels of affected individuals. The primarily endogenous syndrome is based on vasculitis, thrombosis, and intimal proliferation, involving defence cells, interleukins, chemokines, and acute phase proteins and accompanied by alterations in clinical chemistry, metabolome, and liver transcriptome. The complexity of metabolic alterations and the influence of the boar led to hypothesize a polygenic architecture of SINS.

View Article and Find Full Text PDF

Influence of drought stress on phosphorus dynamics and maize growth in tropical ecosystems.

BMC Plant Biol

January 2025

Center for Eco-Environment Restoration of Hainan Province, School of Ecology, Hainan University, Haikou, 570228, China.

Drought has a significant impact on ecosystem functions, especially on the biogeochemical cycling of phosphorus (P), which is a crucial nutrient for plant growth and productivity. Despite its importance, the effects of different drought scenarios on soil P cycling and availability remain poorly understood in previous studies. This study simulated drought conditions in tropical soils using maize as a test crop under varying field capacity (FC) levels (100%, 80%, 60%, 40%, and 20%) over a 60-day pot experiment.

View Article and Find Full Text PDF

Effect of Application Mode and Aging on Microtensile Bond Strength of Universal Adhesives to Enamel of Primary Teeth.

Int J Paediatr Dent

January 2025

Department of Paediatric Dentistry, Medical Centre for Dentistry, University Medical Centre Giessen and Marburg GmbH (Campus Giessen), Justus-Liebig-University, Giessen, Germany.

Background: Limited reports are available regarding bonding of universal adhesives to primary teeth' enamel.

Aim: To evaluate the effect of application mode and aging on microtensile bond strength (μTBS) of universal adhesives to primary enamel.

Design: Ninety-six human primary molars were randomly assigned to three groups: SU: Scotchbond Universal (3M); CU: Clearfil Universal Bond Quick (Kuraray Noritake); iBU: iBond Universal (Heraeus Kulzer), then subdivided according to phosphoric acid etching time into three subgroups (SG): SG1: 0s; SG2: 15s; SG3: 30s.

View Article and Find Full Text PDF

T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice.

Mucosal Immunol

January 2025

Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States. Electronic address:

Immunoglobulin A (IgA), the most abundantly produced antibody at mucosal surfaces, is thought to play key roles in immune responses to respiratory and enteric pathogens and in the regulation of commensal colonization. Low IgA levels have been associated with recurrent infections and immune dysregulation, including inflammatory bowel disease and autoimmunity. Levels of IgA in maternal breast milk and infant stool are both inversely associated with the emergence of immune responses to food antigens in infants and, in naturally resolving food sensitivity and immunotherapy protocols, the induction of IgA antibodies to dietary antigens has been associated with the acquisition of food tolerance.

View Article and Find Full Text PDF

Intimal Sarcoma of the Lower Pulmonary Vein Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Case Report and Comprehensive Literature Review.

Cardiovasc Pathol

January 2025

Section Cytopathology, Institute of Pathology, University Medical Center Hamburg-Eppendorf UKE, D-20246 Hamburg, Germany; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Giessen, Germany.

Intimal sarcoma of blood vessels is a rare, aggressive tumor originating from vascular endothelial cells. This report presents a 22-year-old male diagnosed with an intimal sarcoma of the lower pulmonary vein, detailing diagnosis, treatment, and prognosis information. Additionally, this report explores the application application of Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA) alongside with Rapid Remote Online Evaluation (ROLE) for identifying a mass-like lesion in the pulmonary vein.

View Article and Find Full Text PDF

Adeno-associated viruses (AAV) are among the leading vectors for in vivo gene therapy. The purification of AAV remains a bottleneck as it typically requires multiple individual process steps, often resulting in product loss and high costs. Current downstream processes are usually serotype-specific and rely primarily on expensive affinity resins.

View Article and Find Full Text PDF

Nutritional and Sensory Properties of Meat Analogues: A Current Overview and Future Considerations.

J Agric Food Chem

January 2025

Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Gießen, Germany.

For centuries, meat has been a staple in the human diet, cherished for its rich protein content, vitamins, appealing texture, and umami flavor. The future supply is, however, tenuous as the global population continues to grow. Additional issues regarding animal welfare, adverse health effects, and the environmental impact of meat production have accelerated the development of meat analogues (MAs) over the last decades.

View Article and Find Full Text PDF

Background: Total knee arthroplasty (TKA) is one of the most common orthopaedic procedures and the number of patients which undergo TKA will continue to rise in the coming years. Consecutively, the number of necessary revision surgeries will increase. One of the main reasons for revision surgery is aseptic loosening because of a so-called stress-shielding effect.

View Article and Find Full Text PDF

IRE1 is a Promising Therapeutic Target in Pancreatic Cancer.

Am J Physiol Cell Physiol

January 2025

Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Pancreatic cancer (PC) is one of the most aggressive malignancies, characterized by an increasing incidence and unfavorable prognosis. Despite recent advances, surgical resection combined with chemotherapy remains the only potentially curative therapeutic option. Therefore, it is of paramount importance to identify novel therapeutic targets and develop effective treatment strategies.

View Article and Find Full Text PDF

Decoding the rhythmic representation and communication of visual contents.

Trends Neurosci

January 2025

Neural Computation Group, Department of Mathematics and Computer Science, Physics, Geography, Justus-Liebig-Universität Gießen, Gießen 35392, Germany; Center for Mind, Brain and Behavior (CMBB), Philipps-Universität Marburg, Justus-Liebig-Universität Gießen & Technische Universität Darmstadt, Marburg 35032, Germany. Electronic address:

Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the representation and communication of visual contents. Collating a set of recent studies that used multivariate decoding methods on rhythmic brain signals, we highlight such rhythmic content representations in visual perception, imagery, and prediction.

View Article and Find Full Text PDF

Concentrations of pollutants like pharmaceuticals in soils typically decrease over time, though it often remains unclear whether this dissipation is caused by the transformation of the pollutant or a decreasing extractability. We developed a mathematical model that (1) explores the plausibility of different dissipation pathways, and (2) allows the quantification of concentration differences between aqueous soil extracts and soil solution. The model considers soil particles as uniform spheres, kinetic sorption towards an equilibrium (Freundlich model), and two dissipation pathways, irreversible transformation and mineralization (following 1 order kinetics) as well as the formation of non-extractable residues intraparticle diffusion.

View Article and Find Full Text PDF

Compared with uncomplicated urinary tract infections (UTIs), complicated UTIs (cUTIs) including acute pyelonephritis (AP) present with significant morbidity, a higher risk of treatment failure and typically require longer courses of treatment, or alternative antibiotics. The emergence of drug-resistant organisms represents a considerable challenge in the treatment of patients with cUTIs/AP and has limited antibiotic options. Carbapenems are considered the current last line of therapy, however, carbapenem resistance represents a growing problem.

View Article and Find Full Text PDF

Introduction: Schistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful level of selectivity, there is a compelling need to expand the chemical space available for synthesizing new, potent, and selective PK inhibitors. Small-molecule inhibitors targeting the ATP pocket of the catalytic domain of PKs have the potential to become drugs devoid of (major) side effects, particularly if they bind selectively.

View Article and Find Full Text PDF

Echocardiography of the right heart in pulmonary arterial hypertension: insights from the ULTRA RIGHT VALUE study.

Eur Heart J Imaging Methods Pract

January 2025

Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.

Aims: Outcome in pulmonary arterial hypertension (PAH) is determined by right ventricular (RV) function adaptation to increased afterload. Echocardiography is easily available to assist bedside evaluation of the RV. However, no agreement exists about the feasibility and most relevant measurements.

View Article and Find Full Text PDF

All-solid-state Li-S batteries with fast solid-solid sulfur reaction.

Nature

January 2025

Beijing Key Laboratory for Theory and Technology of Advanced Battery Materials, School of Materials Science and Engineering, Peking University, Beijing, China.

With promises for high specific energy, high safety and low cost, the all-solid-state lithium-sulfur battery (ASSLSB) is ideal for next-generation energy storage. However, the poor rate performance and short cycle life caused by the sluggish solid-solid sulfur redox reaction (SSSRR) at the three-phase boundaries remain to be solved. Here we demonstrate a fast SSSRR enabled by lithium thioborophosphate iodide (LBPSI) glass-phase solid electrolytes (GSEs).

View Article and Find Full Text PDF

Background: Lifetime treatment of aortic valve disease is a matter of increasing debate. Although the risks of a second aortic valve intervention are recognized, little attention has been given to the challenges of a third.

Objectives: This study delves into the clinical characteristics, indications, and outcomes of patients undergoing 3 aortic valve interventions.

View Article and Find Full Text PDF

Background And Aims: Patients with very early-onset inflammatory bowel disease (VEO-IBD), with an age of onset < 6 years, can present with severe manifestations and may require biologic therapy. Infliximab and adalimumab are approved for induction and maintenance in pediatric IBD patients but are licensed only above the age of 6 years. Effectiveness and safety data on adalimumab in this patient population are lacking.

View Article and Find Full Text PDF

Purpose: The spot size of scanned particle beams is of crucial importance for the correct dose delivery and, therefore, plays a significant role in the quality assurance (QA) of pencil beam scanning ion beam therapy.

Materials And Methods: This study compares 5 detector types-radiochromic film, ionization chamber (IC) array, flat panel detector, multiwire chamber, and IC-for measuring the spot size of proton and carbon ion beams.

Results: Variations of up to 30% were found between detectors, underscoring the impact of detector choice on QA outcomes.

View Article and Find Full Text PDF

Background: The integration of real-world evidence (RWE) from real-world data (RWD) in clinical research is crucial for bridging the gap between clinical trial results and real-world outcomes. Analyzing routinely collected data to generate clinical evidence faces methodological concerns like confounding and bias, similar to prospectively documented observational studies. This study focuses on additional limitations frequently reported in the literature, providing an overview of the challenges and biases inherent to analyzing routine clinical care data, including health claims data (hereafter: routine data).

View Article and Find Full Text PDF

Multi-environment field trials for wheat yield, stability and breeding progress in Germany.

Sci Data

January 2025

Section of Intensive Plant Food Systems, Albrecht Daniel Thaer-Institute of Agricultural and Horticultural Sciences, Humboldt Universität zu Berlin, Berlin, Germany.

Multi-environmental trials (MET) with temporal and spatial variance are crucial for understanding genotype-environment-management (GxExM) interactions in crops. Here, we present a MET dataset for winter wheat in Germany. The dataset encompasses MET spanning six years (2015-2020), six locations and nine crop management scenarios (consisting of combinations for three treatments, unbalanced in each location and year) comparing 228 cultivars released between 1963 and 2016, amounting to a total of 526,751 data points covering 24 traits.

View Article and Find Full Text PDF

Breast ultrasound has been established for many years as an important method in addition to mammography for clarifying breast findings. The goal of the Best Practice Guidelines Part III of the DEGUM breast ultrasound working group is to provide colleagues working in senology with information regarding the specific medical indications for breast ultrasound in addition to the current ultrasound criteria and assessment categories published in part I and the additional and optional sonographic diagnostic methods described in part II. The value of breast ultrasound for specific indications including follow-up, evaluation of breast implants, diagnostic workup of dense breast tissue, diagnostic workup during pregnancy and lactation, and the diagnostic workup of breast findings in men is discussed.

View Article and Find Full Text PDF