281 results match your criteria: "Universitäts-Frauenklinik Kantonspital[Affiliation]"

Purpose Of Review: Transurethral resection of bladder tumor (TURBT) remains the basis of bladder tumor diagnosis and an effective means of treating nonmuscle invasive bladder cancer (NMIBC). There are several limitations to this procedure: TURBT may cause free floating of malignant cells in the bladder and as a result re-implantation and early recurrence. Also, it does not allow the pathologist to define the correct spatial orientation of the specimen.

View Article and Find Full Text PDF

Safety and Effectiveness of Glargine 300 U/ml After Switching from Basal Insulins in Patients with Type 1 Diabetes: COMET-T Study.

Diabetes Ther

January 2025

Abteilung für Diabetologie, Endokrinologie, Gastroenterologie und Klinische Forschung, Kinder- und Jugendkrankenhaus Auf der Bult, Hannover, Germany.

Introduction: Appropriate glycemic control is paramount for people with type 1 diabetes (PwT1D) by the effective delivery of exogenous insulin. However, glycemic variability and the risk of severe hypoglycemia must be reliably controlled.

Methods: COMET-T is a prospective, multicenter, observational study conducted in Germany, Austria, and Switzerland during 2021-2022 to assess the effectiveness and safety of insulin glargine 300 U/ml (Gla-300) after switching from other basal insulins.

View Article and Find Full Text PDF

Directed protein evolution is central to biomedical applications but faces challenges such as experimental complexity, inefficient multiproperty optimization, and local maxima traps. Although in silico methods that use protein language models (PLMs) can provide modeled fitness landscape guidance, they struggle to generalize across diverse protein families and map to protein activity. We present EVOLVEpro, a few-shot active learning framework that combines PLMs and regression models to rapidly improve protein activity.

View Article and Find Full Text PDF

The SIMPL'HIV study investigated whether switching to dolutegravir (DTG) + emtricitabine (FTC) was noninferior to continuing combined antiretroviral therapy for maintaining HIV-1 suppression at 144 weeks. The study demonstrated that viral suppression, CD4 gains, adverse events, quality of life, and patient satisfaction were comparable between groups, confirming DTG + FTC's safety and efficacy for long-term management of HIV-1 infection.

View Article and Find Full Text PDF

Purpose: To determine whether periprosthetic drain insertion for hernioplasty using sublay mesh augmentation influences retromuscular fluid collections (RFC) and the clinical course.

Methods: Forty-two patients with open repair of midline hernias (M2-4, W1, European Hernia Society classification) were allocated to groups with or without retromuscular drains. Subcutaneous drainages were used in both groups to avoid confounding from surgical site occurrences due to superficial, subcutaneous fluid collections.

View Article and Find Full Text PDF

Purpose: Urinary sepsis is the leading cause of mortality in the setting of endourological procedures for stone treatment such as URS and PCNL; renal stones themselves may be a source of infection. Aim of this study is to determine the diagnostic accuracy of stone cultures (SC) collected during URS and PCNL in predicting post-operative septic complications, compared to preoperative bladder urine culture (BUC).

Methods: We performed a systematic review (SR) of literature according to the PRISMA guidelines; Literature quality was evaluated according to The Risk Of Bias In Non-randomized Studies-of Interventions (ROBINS-I) assessment tool.

View Article and Find Full Text PDF

The accurate identification of intraoperative levels is of paramount importance in spinal surgery, particularly in cases of obesity or anatomical anomalies affecting the thoracic spine. The aim of this work was to clarify whether the preoperative percutaneous placement of fiducial markers under local anesthesia only, with minimal discomfort to the patient, can be performed safely and efficiently. Patients treated at our institution between June 2019 and June 2020 for thoracic intraspinal lesions with preoperative percutaneous gold fiducial placement were analyzed.

View Article and Find Full Text PDF
Article Synopsis
  • The study looks at how the size of the prostate affects patients’ recovery and symptoms after a surgery called RASP, which helps treat an enlarged prostate (BPH).
  • They reviewed 25 articles and found that patients with smaller prostates had worse symptoms before surgery but improved more after, while those with larger prostates still had some moderate symptoms.
  • The researchers concluded that RASP is a safe and effective surgery for treating BPH, but more studies are needed to understand how prostate size influences the results.
View Article and Find Full Text PDF

Background And Objective: The widespread adoption and rapid integration of new technologies and techniques in endoscopic and laser bladder interventions, particularly endoscopic enucleation, have led to new types of bladder injuries. This underscores the need for an intraoperative injury classification system. This study aims to develop and validate the Bladder Injury Classification System for Endoscopic Procedures (BICEP), which standardizes the classification of complications and intervention requirements.

View Article and Find Full Text PDF

Objectives: To evaluate the early learning curve of BipolEP (Bipolar Enucleation of the Prostate).

Subjects/patients And Methods: We conducted a retrospective, multicenter analysis of surgical and functional outcomes of patients treated with BipolEp for BPO (benign prostatic obstruction). We evaluated the first 20 cases of BipolEp performed by four different surgeons in three different countries.

View Article and Find Full Text PDF

Background: We aimed to determine if preoperative prostate volume-enucleated weight concordance predicts short-term anatomical endoscopic enucleation of the prostate (AEEP) outcomes using the REAP international database.

Methods: 649 patients with data on both preoperative ultrasound-derived prostate volume and enucleated specimen weight were analyzed. Linear regression was used to investigate the effect of volume-weight concordance on postoperative outcomes.

View Article and Find Full Text PDF

The artificial intelligence advantage: Supercharging exploratory data analysis.

Knee Surg Sports Traumatol Arthrosc

November 2024

Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Explorative data analysis (EDA) is a critical step in scientific projects, aiming to uncover valuable insights and patterns within data. Traditionally, EDA involves manual inspection, visualization, and various statistical methods. The advent of artificial intelligence (AI) and machine learning (ML) has the potential to improve EDA, offering more sophisticated approaches that enhance its efficacy.

View Article and Find Full Text PDF
Article Synopsis
  • Directed evolution of proteins is crucial for various fields but is traditionally labor-intensive and limited in efficiency.
  • The introduction of EVOLVEpro, a few-shot active learning framework, enhances protein activity optimization using protein language models and activity predictors, achieving significant improvements in fewer rounds.
  • EVOLVEpro demonstrated substantial advancements across different proteins and applications, potentially transforming AI-guided protein engineering in biology and medicine.
View Article and Find Full Text PDF

in the 21 century.

Public Health Action

June 2024

Department of Infectious Diseases and Hospital Hygiene, University Hospital Zurich, University of Zurich, Zurich.

The occurrence of transient culture positivity for (MTB), known as , poses significant challenges in understanding its spectrum and implications. Here, we report a case of transient culture positivity, oscillating between detectable and non-detectable MTB cultures with minimal radiological features and review the literature on this phenomenon. The scarcity of scientific literature on this subject stems from the inherent impossibility of systematically studying mirage de tuberculose.

View Article and Find Full Text PDF

Background And Objective: Thulium fiber laser (TFL) emerged as a competitor of holmium:yttrium-aluminum-garnet (Ho:YAG) laser for anatomic enucleation of the prostate (AEEP) in men with lower urinary tract symptoms (LUTS) related to benign prostatic obstruction (BPO). The aim was to compare the surgical outcomes of Ho:YAG and TFL for AEEP.

Methods: A literature search was conducted to identify reports published from inception until January 2024.

View Article and Find Full Text PDF

The Breast Committee of the Arbeitsgemeinschaft Gynäkologische Onkologie (German Gynecological Oncology Group, AGO) presents the 2024 update of the evidence-based recommendations for the diagnosis and treatment of patients with locally advanced and metastatic breast cancer.

View Article and Find Full Text PDF

Introduction: Each year the interdisciplinary AGO (Arbeitsgemeinschaft Gynäkologische Onkologie, German Gynecological Oncology Group) Breast Committee on Diagnosis and Treatment of Breast Cancer provides updated state-of-the-art recommendations for early and metastatic breast cancer.

Methods: The updated evidence-based treatment recommendations for early and metastatic breast cancer have been released in March 2024.

Results And Conclusion: This paper concisely captures the updated recommendations for early breast cancer chapter by chapter.

View Article and Find Full Text PDF
Article Synopsis
  • Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease leading to muscle weakness and respiratory issues, and arimoclomol has shown potential neuroprotective effects in animal studies.
  • The ORARIALS-01 trial was a multicenter, double-blind study that assessed the safety and efficacy of arimoclomol in ALS patients, involving random assignment to either the drug or a placebo.
  • A total of 245 patients participated, and the primary goal was to evaluate treatment outcomes over 76 weeks, analyzing both efficacy and safety data among the participants.
View Article and Find Full Text PDF
Article Synopsis
  • The SIMPL'HIV study aimed to compare the costs and effectiveness of dual maintenance therapy and simplified patient-centered monitoring (PCM) versus standard monitoring in HIV care over 48 weeks.
  • It analyzed the financial implications of both treatment approaches, including costs for consultations, drug therapy, lab tests, and hospitalizations, and involved participants choosing more flexible monitoring options.
  • Results indicated no significant difference in total costs between the PCM group and the standard monitoring group while also assessing secondary health outcomes such as renal function, lipids, glucose, weight, and patient satisfaction.
View Article and Find Full Text PDF

Novel Thulium Lasers and Ho:YAG pulse modifications.

World J Urol

May 2024

Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group, Hall in Tirol, Austria.

View Article and Find Full Text PDF

Purpose: The primary aim of the study was to evaluate if en-bloc vs. non en-bloc made a difference to intra-, peri- and post-operative surgical outcomes of anatomical endoscopic enucleation (AEEP) in large (> 80 cc) and very large prostates (> 200 cc). The secondary aim was to determine the influence of energy and instruments used.

View Article and Find Full Text PDF

The physiological, hormonal and biomechanical changes during pregnancy may trigger sleep disordered breathing (SDB) in pregnant women. Pregnancy-related sleep disorders may associate with adverse fetal and maternal outcomes including gestational diabetes, preeclampsia, preterm birth and gestational hypertension. Most of the screening and diagnostic studies that explore SDB during pregnancy were based on questionnaires which are inherently limited in providing definitive conclusions.

View Article and Find Full Text PDF

Reassessing the chronic lymphocytic leukemia International Prognostic Index in the era of targeted therapies.

Blood

June 2024

Department I of Internal Medicine and German CLL Study Group, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

We evaluated the chronic lymphocytic leukemia International Prognostic Index (CLL-IPI) in patients with CLL treated first line with targeted drugs (n = 991) or chemoimmunotherapy (n = 1256). With a median observation time of 40.5 months, the 3-year progression-free survival (PFS) rates for targeted drug-treated patients varied by CLL-IPI risk group: 96.

View Article and Find Full Text PDF

Ejaculation sparing of classic and minimally invasive surgical treatments of LUTS/BPH.

Prostate Cancer Prostatic Dis

April 2024

Department of Urology, Spital Thurgau AG, Kantonspital Frauenfeld, Frauenfeld, Switzerland.

Background: The surgical landscape for Lower Urinary Tract Symptoms (LUTS) and Benign Prostatic Hyperplasia (BPH) has evolved with the introduction of Minimally Invasive Surgical Therapies (MISTs), recognizing the impact of sexual function on patients' well-being, and prioritizing ejaculation-sparing approaches.

Methods: This systematic review explored ejaculation sparing after classic endoscopic procedures and MISTs (iTind, Rezūm, Urolift, Aquablation, and TPLA) and a literature search yielded 41 studies.

Results: While all procedures demonstrated efficacy in improving LUTS/BPH symptoms (IPSS, QoL, Qmax), a subset of studies evaluated ejaculatory function.

View Article and Find Full Text PDF