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Inspiratory muscle training improves autonomic modulation and exercise tolerance in chronic obstructive pulmonary disease subjects: A randomized-controlled trial.

Respir Physiol Neurobiol

May 2019

Laboratory of Cardiovascular Adaptations to Exercise - LACORE, Universidade Federal do Maranhão, São Luís, Brazil; Programa de Pós-Graduação em Saúde do Adulto - PPGSAD, Universidade Federal do Maranhão, São Luís, Brazil; Cardiopulmonary Rehabilitation Center, Universidade Federal do Maranhão University Hospital 'Presidente Dutra', São Luís, Brazil; Programa de Doutorado da Rede Nordeste de Biotecnologia - RENORBIO, Brazil; Programa de Pós Graduação em Educação Física, Universidade Federal do Maranhão, São Luís, Brazil. Electronic address:

Objectives: We aimed to evaluate the effect a regular inspiratory muscle training program on autonomic modulation measured by heart rate variability, exercise capacity and respiratory function in chronic obstructive pulmonary disease subjects (COPD).

Design: Single-center controlled study, with balanced randomization (1:1 for two arms).

Setting: A COPD reference hospital localized in Sao Luís, Brazil.

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