1 results match your criteria: "Universidad de Buenos Aires. jorge.ferraris@hospitalitaliano.org.ar[Affiliation]"
Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: age dependency and pharmacological interaction with steroids.
Pediatr Transplant
August 2011
Servicio de Nefrología Pediátrica, Hospital Italiano de Buenos Aires Departamento de Pediatría, Universidad de Buenos Aires.
Article Synopsis
- This study investigates how the CYP3A5 enzyme affects tacrolimus (TAC) dosing in pediatric kidney transplant patients, focusing on the differences between genetic polymorphisms of CYP3A5.
- The researchers found that 79% of the participants had the non-expressing CYP3A5*3/*3 allele, requiring higher daily doses of TAC, while those with the CYP3A5*1/*3 allele had lower TAC levels for similar doses.
- Additionally, the study highlights that prepubertal patients tend to need higher TAC doses and experience different pharmacological interactions with steroids compared to pubertal patients, suggesting the need for personalized TAC therapy based on genetic testing.