Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis.

Low biocompatibility of peritoneal dialysis fluid (PDF) injures mesothelial cells and activates their stress response. In this study, we investigated the role of heat shock proteins (HSP), the main cytoprotective effectors of the stress response, in cytoskeletal stabilization of mesothelial cells in experimental peritoneal dialysis. In cultured human mesothelial cells, cytoskeletal integrity was assessed by detergent extractability of marker proteins following in vitro PDF exposure.

[Formula creatinine clearance as a substitute for 24-hour creatine clearance in children with kidney transplantation].

Despite many theoretical advantages, formula-creatininclearance (Schwartz et al, Journal of Pediatrics 1976) has not found broad clinical acceptance in everyday pediatric patient care. In this study we report our results of long term observations (11.7 +/- 6.

[Anamnesis, clinical aspects and laboratory findings in juvenile "aseptic meningitis" in Lyme borreliosis--a meta-analysis].

Lyme borreliosis is currently suspected to be capable of mimicking nearly all known neurologic symptoms and disease entities. The goal of our study is to define the associated anamnestic, clinical and laboratory findings in aseptic meningitis and Lyme borreliosis in childhood by a meta-analysis of recent literature and of our own data. We defined by means of 63 cases derived of 10 publications and own data a list of mainly rather unspecific parameters like insidious onset, fever, mild meningism, encephalitic symptoms and cranial nerve involvement.

[Carbohydrates in the treatment of glycogenoses].

Glycogen storage diseases (GSD) include inborn errors in glycogen synthesis and degradation which, like most metabolic diseases, evades any therapeutical concept up to now. Nevertheless, in a subgroup of glycogenoses, characterized by functional absence of the key glycogenolytic enzyme glucose-6-phosphatase (GSD-1), dietary treatment is able to ensure almost normal development of affected patients. The principle of treatment consists of oral application of raw cornstarch, which is hydrolyzed slowly in the intestinum resulting in normoglycemia over a period of several hours.

[The obese patient and surgical intervention].

In obese patients the risks of morbidity and mortality is increased with high probability in surgical procedures. The secondary metabolic disturbances of obesity do not require special regimes for parenteral and enteral nutrition in most cases, since the common marked hyperinsulinemia is normalized quickly during the catabolic phase. Due to a preoperative weight reduction of approximately 10% a normalization of the disturbed metabolic parameters and impaired lung function almost can be achieved.

[New aspects in the treatment of patent ductus arteriosus in premature newborns with respiratory insufficiency].

The efficacy of prolonged indomethacin treatment of sPDA was studied using a new, diagnostic method, the two-dimensional Doppler echocardiography (2-DDE). 35 ventilated preterm infants with sPDA (gestational age: 31.6 +/- 2.

[Glucose tolerance test in morbidly obese children and adolescents].

Oral glucose tolerance tests (50 g/m2 body surface) were performed in fifty-two children and adolescents (28 girls and 24 boys) aged 3.1 to 16.8 (mean +/- SD 11.