2 results match your criteria: "Univ. of Toledo College of Medicine[Affiliation]"

We recently demonstrated that the cardiotonic steroid marinobufagenin (MBG) induced fibrosis in rat hearts through direct stimulation of collagen I secretion by cardiac fibroblasts. This stimulation was also responsible for the cardiac fibrosis seen in experimental renal failure. In this study, the effect of MBG on the development of renal fibrosis in rats was investigated.

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Isoform specificity of Na-K-ATPase-mediated ouabain signaling.

Am J Physiol Renal Physiol

April 2008

Dept. of Physiology and Pharmacology, Univ. of Toledo College of Medicine, 3035 Arlington Ave., Toledo, OH 43614-5804, USA.

The ion transporter Na-K-ATPase functions as a cell signal transducer that mediates ouabain-induced activation of protein kinases, such as ERK. While Na-K-ATPase composed of the alpha(1)-polypeptide is involved in cell signaling, the role of other alpha-isoforms (alpha(2), alpha(3), and alpha(4)) in transmitting ouabain effects is unknown. We have explored this using baculovirus-directed expression of Na-K-ATPase polypeptides in insect cells and ERK phosphorylation as an indicator of ouabain-induced signaling.

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