Bradykinin (BK) enhances diuresis and natriuresis in saline volume-expanded dogs.

15 micrograms bradykinin was given with large amount of physiological saline solution intravenously to dogs. Significantly greater diuresis and natriuresis were obtained compared with those of simple saline volume expansion experiments. Bradykinin in small doses which were selected as giving no influence on blood pressure enhanced additively diuresis and natriuresis, similarly with subpressor doses of A II, AVP, and MX in saline volume expanded dogs.

Erythrocyte adenine PRPP availability in two types of APRT deficiency using silicon oil method.

Erythrocyte phosphoribosylpyrophosphate availability for adenine was measured by silicon oil method previously described. The homozygotes of Japanese type APRT deficiency (n = 6, from 4 families) showed 4.3 +/- 2.

[Histological differential diagnosis of early colorectal carcinoma].

Adenoma was divided into 3 grades of dysplasia, severe, moderate and mild, and histological features of moderate dysplasia were clarified. Severe dysplasia is synonymous with mucosal carcinoma and moderate dysplasia is a borderline lesion between malignant and benign condition. From various investigations such as serial section, electronmicroscopy, immunohistochemistry and DNA analysis, moderate dysplasia was shown to include the earliest stage of carcinoma.

[Diagnosis of leukemia and lymphoma].

Leukemia and lymphomas were traditionally diagnosed by cytology and histology, but recently analyses of cell surface markers, gene rearrangement and so on have been used to make accurate the diagnosis. The differential diagnosis and some aspects of early diagnosis of hematological malignancies were interpreted in this paper.

[A case of metastasis of renal cell carcinoma to the abdominal wall 13 years after nephrectomy].

A 68-year-old man was admitted to our hospital complaining of a tumor of the left abdominal wall. Thirteen years previously, had undergone a nephrectomy of a right renal cell carcinoma with T2, N0, M0, manifestations stage I. Prior to his second operation, a parenchymal tumor was strongly suspected.

[Comparative studies on the DNA content of human gastric cancer cells and its metastatic foci].

Comparative cellular DNA content measurements have been done on two sites differing from each other in their anatomical location, in 16 cases of gastric cancer by means of microphotometry. In addition, comparisons on the DNA stemline of the original gastric lesions and their metastatic lesions (8 cases of liver metastases and 9 cases of lymph node metastases) also were done. The main stemlines in four cases (25%) out of 16 gastric cancers exhibited different main DNA stemlines from the other sites in the same lesion, although in the other 12 cases examined, two sites showed the same DNA stemlines to each other.