Synthesis and leishmanicidal evaluation of sulfanyl- and sulfonyl-tethered functionalized benzoate derivatives featuring a nitroimidazole moiety.

A series of new nitroimidazole-containing derivatives was synthesized by coupling of 2-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethylthio]ethanol with diversely substituted benzoic acids. Upon treatment with m-CPBA, 12 of these sulfanyl compounds were further oxidized to their sulfonyl analogs. All the 26 synthetic compounds were examined for in vitro activity against Leishmania (V.

Interaction of eta mesons with nuclei.

Back in the mid-1980s, a new branch of investigation related to the interaction of eta mesons with nuclei came into existence. It started with the theoretical prediction of possible exotic states of eta mesons and nuclei bound by the strong interaction and later developed into an extensive experimental program to search for such unstable states as well as understand the underlying interaction via eta-meson producing reactions. The vast literature of experimental as well as theoretical works that studied various aspects of eta-producing reactions such as the π(+)n → ηp, pd → (3)Heη, p (6)Li → (7)Be η and γ (3)He → η X, to name a few, had but one objective in mind: to understand the eta-nucleon (ηN) and hence the η-nucleus interaction which could explain the production data and confirm the existence of some η-mesic nuclei.

Herbivory on bracken (Pteridium spp.) by Bolax palliata Burmeister (Coleoptera: Scarabaeidae), a poliphagous beetle of the Venezuelan Andes.

Herbivore attack by Bolax palliata Burmeister is reported on two sympatric bracken species: Pteridium caudatum (L.) Maxon and P. arachnoideum (Kaulf.

CAN: chain of nodes approach to direct rule induction.

CAN is a heuristic algorithm that employs an information theoretic measure to learn rules. CAN approach distinguishes itself from other approaches by being direct, meaning that there are no intermediate representations, an induced rule is never altered in later stages and only tests that appear in the final solution are generated. In the selection of rule conditions (tests) existing rule induction algorithms do not provide a satisfactory answer to the partitioning of the feature space of discrete feature variables with nonordered qualitative values (i.

Trajectory generation and modulation using dynamic neural networks.

Generation of desired trajectory behavior using neural networks involves a particularly challenging spatio-temporal learning problem. This paper introduces a novel solution, i.e.

Cholinergic modulation of the sleep state-dependent P13 midlatency auditory evoked potential in the rat.

Injections into the pedunculopontine nucleus (PPN) of the cholinergic receptor agonist, carbachol (CAR), were found to reduce the amplitude of the vertex-recorded, sleep state-dependent P13 midlatency evoked potential in a dose- and time-dependent manner. This effect was blocked or reduced by pretreatment with the muscarinic receptor antagonist, scopolamine, injected into the PPN.