3 results match your criteria: "Univ. LilleInserm[Affiliation]"
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.
Elife
April 2021
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological roles. We found that IL-27 induces more sustained STAT1 phosphorylation than IL-6, with the two cytokines inducing comparable levels of STAT3 phosphorylation.
View Article and Find Full Text PDFHepatic Molecular Signatures Highlight the Sexual Dimorphism of Nonalcoholic Steatohepatitis (NASH).
Hepatology
March 2021
Univ. LilleInserm, CHU LilleInstitut Pasteur de LilleU1011-EGIDLilleFrance.
Background And Aims: Nonalcoholic steatohepatitis (NASH) is considered as a pivotal stage in nonalcoholic fatty liver disease (NAFLD) progression, given that it paves the way for severe liver injuries such as fibrosis and cirrhosis. The etiology of human NASH is multifactorial, and identifying reliable molecular players and/or biomarkers has proven difficult. Together with the inappropriate consideration of risk factors revealed by epidemiological studies (altered glucose homeostasis, obesity, ethnicity, sex, etc.
View Article and Find Full Text PDFFXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements.
J Lipid Res
September 2019
Departments of Pediatrics University of Groningen, Groningen 9700 RB, The Netherlands; Laboratory Medicine, University of Groningen, Groningen 9700 RB, The Netherlands. Electronic address:
Article Synopsis
- FXR (NR1H4) is a nuclear receptor that influences lipid and energy metabolism but its specific role in fat tissue is not well understood, despite its moderate expression there.
- Transgenic mice expressing higher levels of human FXR in adipose tissue show larger fat cells and changes in the extracellular matrix, but their capacity to expand and manage fat decreases with age and high-fat conditions.
- The impaired ability to store fat in these mice results in higher blood free fatty acids, fat build-up in other organs, and insulin resistance, highlighting FXR's importance in fat tissue structure and overall lipid balance in the body.