The influence of gemcitabine on the CD4/CD8 ratio in patients with solid tumours.

Gemcitabine (dFdC) is a novel pyrimidine antimetabolite with documented antineoplastic activity against metastatic non-small cell lung cancer (NSCL), pancreatic carcinoma, ovarian and breast cancer. The side effects of gemcitabine are generally mild; severe infections are reported in less than Ilo of patients. In contrast, other new nucleoside analogues such as the purine antimetabolite fludarabine lead to a significant alteration of the CD4/CD8 lymphocyte ratio associated with an increased risk for opportunistic infections.

Ability of tannins extracted from the leaves of various trees and shrubs to inhibit the biomarkers of tumor promotion in mouse skin in vivo.

Eight heterogeneous tannin samples (HTSs) extracted from various tree/shrub leaves of African and Himalayan origin were tested topically for their ability to inhibit the biomarkers of tumor promotion in mouse skin in vivo. HTS2 (from Dichostachys cinerea) and HTS6 (from Cassia sieberiana) consistently inhibit tumor promoter-stimulated ornithine decarboxylase activity, DNA synthesis, hydroperoxide production, and edema formation almost as much as loblolly pine bark condensed tannin (LPB-CT), which is known to inhibit skin tumor promotion. The other HTSs tested have lesser or only partial inhibitory effects.

[Survival ability of Trichomonas vaginalis in mineral baths].

The role of mineral thermal baths and particularly of bath fittings such as benches and toilet seats in the spreading of Trichomonas vaginalis is controversial. In order to clarify the possibility of transmission by smear infection of this ubiquitous urogenital parasite the ability to survive was investigated in 11 mineral baths in Baden-Württemberg by contamination of water samples of varying mineral content. In addition, Trichomonas-contaminated water samples were placed in Petri-dishes on different benches in the bath area to determine the different milieu-factors influencing survival and thus the possibility of smear infections.