Exploring the Substitution of Fe(III) by Gd(III) in Nanomagnetite.

A promising superparamagnetic nanomagnetite dipped with Gd was synthesized for possible medical applications. Its size and morphology are independent of Gd content ranging from 1 to 5%. Gadolinium (III) replaced Fe(III) in the lattice.

Different forms of fablab organization and their impact on collaboration and innovation.

The aim of this paper is to identify some of the characteristics of innovation and collective work in different fablab organizations. We first define fablabs through a review of literature, situating related questions in the field of ergonomics and focusing our point of view on individual and collective activity. Secondly, we show how the results of our qualitative analyses (performed on data from interviews and observations of fablab managers, users, and projects from 13 fablabs) reveal 3 main types of fablab organization: community-oriented fablabs, academic fablabs and industrial fablabs, in which different activities are carried out.

The Favorable impact of everolimus on Chronic lung allograft dysfunction in lung transplant recipients.

Standard immunosuppressive therapy for lung transplant recipients combines a calcineurin inhibitor, an antimetabolite, and corticosteroids. In an observational, retrospective, monocentric study, we sought to compare the development of chronic lung allograft dysfunction (CLAD) between 37 patients who received this standard therapy (triple-therapy group) and 59 patients who received the mammalian target of rapamycin (mTOR) inhibitor everolimus in addition to the standard therapy (quadruple-therapy group). In the quadruple-therapy group, the time elapsed from transplantation to everolimus introduction (median [25th-75th percentile]) was 12 [7-25] months.

The socioeconomic and environmental niche of protected areas reveals global conservation gaps and opportunities.

The global network of protected areas has rapidly expanded in the past decade and is expected to cover at least 30% of land and sea by 2030 to halt biodiversity erosion. Yet, the distribution of protected areas is highly heterogeneous on Earth and the social-environmental preconditions enabling or hindering protected area establishment remain poorly understood. Here, using fourteen socioeconomic and environmental factors, we characterize the multidimensional niche of terrestrial and marine protected areas, which we use to accurately establish, at the global scale, whether a particular location has preconditions favourable for paestablishment.

Attentional management of cognitive-motor interference in adults during walking: Insights from an EEG study.

Dual-task paradigms, which involve performing cognitive and motor tasks simultaneously, are commonly used to study how attentional resources are allocated and managed under varying task demands. This study aimed to investigate cognitive-motor interferences (CMI) under different levels of cognitive and motor task difficulty without instruction on task prioritization. 17 healthy young adults performed an auditory oddball task with increasing cognitive and motor (walking vs.

Word form generalization across voices: The role of infant sleep.

Infant sleep plays a crucial role in various aspects of language development, including the generalization of visual and auditory stimuli. The relative role of daytime naps and nocturnal sleep in these memory generalization processes is debated, with some studies observing significant generalization following a post-encoding nap and others observing it following nocturnal sleep, but only in cases where a post-encoding nap had occurred on the previous day. We conducted an online experiment with 8-month-old infants to determine whether a nap immediately following auditory exposure to words spoken by one talker enhances infants' recognition of the same word forms produced by a different talker (i.

Unraveling complexity: morbidity factors in elderly kidney transplant recipients.

Background: The rising prevalence of end-stage renal failure in the elderly has led to an increased number of kidney transplantations in older individuals. While age does not solely determine transplant eligibility, frailty in elderly recipients significantly impacts post-transplant outcomes, particularly within the first year.

Methods: The RETRAITE (REnal TRAnsplantIon ouTcome in Elderly recipients) study, a single-center retrospective cohort study at Grenoble Alpes University Hospital (France), examined kidney transplant recipients aged 70 years and above transplanted between 2015 and 2020.

Glycocalyx cleavage boosts erythrocytes aggregation.

The glycocalyx is a complex layer of carbohydrate and protein molecules that surrounds the cell membrane of many types of mammalian cells. It serves several important functions, including cell adhesion and communication, and maintain cell shape and stability, especially in the case of erythrocytes. Alteration of glycocalyx composition represents a cardiovascular health threatening.

Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1.

PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in genome stability. Human PIF1 (hPIF1) is poorly understood, but its functions can become critical for tumour cell survival during oncogene-driven replication stress. Here we report the discovery, via an X-ray crystallographic fragment screen (XChem), of hPIF1 DNA binding and unwinding inhibitors.

Mapping multi-dimensional variability in water stress strategies across temperate forests.

Increasing water stress is emerging as a global phenomenon, and is anticipated to have a marked impact on forest function. The role of tree functional strategies is pivotal in regulating forest fitness and their ability to cope with water stress. However, how the functional strategies found at the tree or species level scale up to characterise forest communities and their variation across regions is not yet well-established.

The interplay of singlet oxygen and ABI4 in plant growth regulation.

Abscisic acid (ABA) and the AP2/ERF (APETALA 2/ETHYLENE-RESPONSIVE FACTOR)-type transcription factor ABA INSENSITIVE 4 (ABI4) control plant growth and development. We review how singlet oxygen, which is produced in chloroplasts of the fluorescent mutant of Arabidopsis thaliana (arabidopsis), and ABI4 may cooperate in transcriptional and translational reprogramming to cause plants to halt growth or demise. Key elements of singlet oxygen- and ABI4-dependent chloroplast-to-nucleus retrograde signaling involve the chloroplast EXECUTER (EX) 1 and EX2 proteins as well as nuclear WRKY transcription factors.

Direct Synthesis of Saturated Alcohols from Conjugated Ketones Using NaBH and Catalytic Amount of CuCN in Ethanol: Additive Catalysis with a Lithium Salt or a Sodium Salt.

A direct, efficient, and highly chemoselective synthesis of saturated alcohols through one-pot sequential 1,4- and 1,2-reduction of cyclic and acyclic conjugated ketones is reported. The saturated alcohols are obtained in very good yields using sodium borohydride (NaBH) as a reducing agent and a catalytic amount of copper(I) cyanide (CuCN) in ethanol as a green solvent. This nontoxic solvent significantly favors full 1,4-reduction, as opposed to methanol.

A mathematical model simulating the adaptive immune response in various vaccines and vaccination strategies.

Vaccination has been widely recognized as an effective measure for preventing infectious diseases. To facilitate quantitative research into the activation of adaptive immune responses in the human body by vaccines, it is important to develop an appropriate mathematical model, which can provide valuable guidance for vaccine development. In this study, we constructed a novel mathematical model to simulate the dynamics of antibody levels following vaccination, based on principles from immunology.

The DYRKP1 kinase regulates cell wall degradation in Chlamydomonas by inducing matrix metalloproteinase expression.

The cell wall of plants and algae is an important cell structure that protects cells from changes in the external physical and chemical environment. This extracellular matrix, composed of polysaccharides and glycoproteins, must be constantly remodeled throughout the life cycle. However, compared to matrix polysaccharides, little is known about the mechanisms regulating the formation and degradation of matrix glycoproteins.

Strong Magnetic Exchange Interactions and Delocalized Mn-O States Enable High-Voltage Capacity in the Na-Ion Cathode P2-Na[MgMn]O.

The increased capacity offered by oxygen-redox active cathode materials for rechargeable lithium- and sodium-ion batteries (LIBs and NIBs, respectively) offers a pathway to the next generation of high-gravimetric-capacity cathodes for use in devices, transportation and on the grid. Many of these materials, however, are plagued with voltage fade, voltage hysteresis and O loss, the origins of which can be traced back to changes in their electronic and chemical structures on cycling. Developing a detailed understanding of these changes is critical to mitigating these cathodes' poor performance.

Hypoventilation training including maximal end-expiratory breath holding improves the ability to repeat high-intensity efforts in elite judo athletes.

Purpose: To investigate the effects of a repeated-sprint training in hypoxia induced by voluntary hypoventilation at low lung volume (RSH-VHL) including end-expiratory breath holding (EEBH) of maximal duration.

Methods: Over a 4-week period, twenty elite judo athletes (10 women and 10 men) were randomly split into two groups to perform 8 sessions of rowing repeated-sprint exercise either with RSH-VHL (each sprint with maximal EEBH) or with unrestricted breathing (RSN, 10-s sprints). Before (Pre-), 5 days after (Post-1) and 12 days after (Post-2) the last training session, participants completed a repeated-sprint ability (RSA) test on a rowing ergometer (8 × 25-s "all-out" repetitions interspersed with 25 s of passive recovery).

An integrated microfluidic platform for on-site qPCR analysis: food allergen detection from sample to result.

Improving food safety is crucial in the context of a "One Health" approach. To guarantee product quality and safety, the food industry, which has a very high turnover rate, needs short time-to-result analyses. Therefore, user-friendly systems at the point-of-need are necessary, presenting relevant analytical information and fulfilling the current regulations.

Molecular Fractionation of Ancient Organic Compounds in Deeply Buried Halite Crystals.

The molecular fractionation of organic compounds through adsorption in minerals has wide implications, including tracing the origins of life, carbon sequestration, and climate change. Here we present the first in situ examination of molecular fractionation within individual crystals via optical-photothermal infrared (O-PTIR) spectroscopy. Our study focuses on a unique inclusion trail within deeply buried halite crystals, characterized by a distinctive orange-to-blue fluorescence gradient, providing primary evidence of molecular variation in ancient carbon-based fluids within the inclusion trail.

Temperature-induced mobility in octacalcium phosphate impacts crystal symmetry: water dynamics studied by NMR crystallography.

Octacalcium phosphate (OCP, Ca(PO)(HPO)·5HO) is a notable calcium phosphate due to its biocompatibility, making it a widely studied material for bone substitution. It is known to be a precursor of bone mineral, but its role in biomineralisation remains unclear. While the structure of OCP has been the subject of thorough investigations (including using Rietveld refinements of X-ray diffraction data, and NMR crystallography studies), important questions regarding the symmetry and H-bonding network in the material remain.

Complex transcriptional regulations of a hyperparasitic quadripartite system in giant viruses infecting protists.

Hyperparasitism is a common pattern in nature that is not limited to cellular organisms. Giant viruses infecting protists can be hyperparasitized by smaller ones named virophages. In addition, both may carry episomal DNA molecules known as transpovirons in their particles.