Use of assistive technology to assess distal motor function in subjects with neuromuscular disease.

Unlabelled: Among the 32 items of the Motor Function Measure scale, 3 concern the assessment of hand function on a paper-based support. Their characteristics make it possible to envisage the use of a tablet instead of the original paper-based support for their completion. This would then make it possible to automate the score to reduce intra- and inter-individual variability.

An open source ultrasonic flowmeter for monitoring the input/output flow rates of wastewater treatment plants.

Sensors play an important role in both the continuous monitoring and intermittent analyses, which are essential for the study of wastewater treatment plant management and conducting related research. Given the significant environmental impact of the issues involved, accurate measurement of the volume of water flowing into and out of treatment plants is a key parameter for plant management, ecotoxicological studies and academic research programs. Traditionally, flow measurements have been based on calibrated weirs or venturi flumes, using water level measurements for conversion into flow, according to established relationships.

First-Principles Assessment of ZnTe and CdSe as Prospective Tunnel Barriers at the InAs/Al Interface.

Majorana zero modes are predicted to emerge in semiconductor/superconductor interfaces, such as InAs/Al. Majorana modes could be utilized for fault tolerant topological qubits. However, their realization is hindered by materials challenges.

Betaine lipids: Biosynthesis, functional diversity and evolutionary perspectives.

Betaine lipids (BL) are relatively understudied non‑phosphorus glycerolipids. They are predominantly found in algae but have also been detected in other unicellular eukaryotes, fungi, bacteria, and some bryophytes and pteridophytes. These extraplastidial lipids are considered as substitute for phospholipids in organisms, particularly under phosphate (Pi) deficiency.

Relations between psychosis and emotion regulation in daily life: A systematic review and meta-analyses of studies using experience sampling methods.

Research has shown that heightened emotionality often precedes psychotic experiences. Understanding how individuals cope with these emotions is crucial for psychosis. While prior studies on emotion regulation (ER) and psychosis have mainly relied on self-report questionnaires, recent research has increasingly utilised daily life methods.

Nanostructured lipid carriers based mRNA vaccine leads to a T cell-inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour model.

Background: mRNA-based cancer vaccines show promise in triggering antitumour immune responses. To combine them with existing immunotherapies, the intratumoral immune microenvironment needs to be deeply characterised. Here, we test nanostructured lipid carriers (NLCs), the so-called Lipidots®, for delivering unmodified mRNA encoding Ovalbumin (OVA) antigen to elicit specific antitumour responses.

Biliary diffusion and antifungal activity of caspofungin and fluconazole in liver transplant recipients: A pilot study.

Invasive candidiasis, including intra-abdominal candidiasis (IAC), is a common complication after liver transplantation. Antifungal drugs such as echinocandins and fluconazole (FCZ) are frequently used to prevent or treat such fungal infections. The diffusion of these antifungals within abdominal body sites has been rarely reported, in particular, in liver transplant recipients.

Neuronal Imaging at 8-Bit Depth to Combine High Spatial and High Temporal Resolution With Acquisition Rates Up To 40 kHz.

A challenge in neuroimaging is acquiring frame sequences at high temporal resolution from the largest possible number of pixels. Measuring 1%-10% fluorescence changes normally requires 12-bit or higher bit depth, constraining the frame size allowing imaging in the kHz range. We resolved Ca or membrane potential signals from cell populations or single neurons in brain slices by acquiring fluorescence at 8-bit depth and by binning pixels offline, achieving unprecedented frame sizes at kHz rates.

α/β hydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation.

Lipid droplets (LDs) are the major sites of lipid and energy homeostasis. However, few LD biogenesis proteins have been identified. Using model microalga , we show that ABHD1, an α/β-hydrolase domain-containing protein, is localized to the LD surface and stimulates LD formation through two actions: one enzymatic and one structural.

Pacmanvirus isolated from the Lost City hydrothermal field extends the concept of transpoviron beyond the family Mimiviridae.

The microbial sampling of submarine hydrothermal vents remains challenging, with even fewer studies focused on viruses. Here we report the first isolation of a eukaryotic virus from the Lost City hydrothermal field, by co-culture with the laboratory host Acanthamoeba castellanii. This virus, named pacmanvirus lostcity, is closely related to previously isolated pacmanviruses (strains A23 and S19), clustering in a divergent clade within the long-established family Asfarviridae.

Transfer of motor and strategy learning in children with Developmental Coordination Disorder (DCD): A scoping review.

Developmental coordination disorder (DCD) is a developmental disorder that affects the learning and execution of motor skills. Little is known about their ability to transfer their learning, i.e.

Intertwined people-nature relations are central to nature-based adaptation to climate change.

Adaptation to climate change is a social-ecological process: it is not solely a result of natural processes or human decisions but emerges from multiple relations within social systems, within ecological systems and between them. We propose a novel analytical framework to evaluate social-ecological relations in nature-based adaptation, encompassing social (people-people), ecological (nature-nature) and social-ecological (people-nature) relations. Applying this framework to 25 case studies, we analyse the associations among these relations and identify archetypes of social-ecological adaptation.

Investigating Parkinson's disease risk across farming activities using data mining and large-scale administrative health data.

The risk of Parkinson's disease (PD) associated with farming has received considerable attention, in particular for pesticide exposure. However, data on PD risk associated with specific farming activities is lacking. We aimed to explore whether specific farming activities exhibited a higher risk of PD than others among the entire French farm manager (FM) population.

Visual attention matters during word recognition: A Bayesian modeling approach.

It is striking that visual attention, the process by which attentional resources are allocated in the visual field so as to locally enhance visual perception, is a pervasive component of models of eye movements in reading, but is seldom considered in models of isolated word recognition. We describe BRAID, a new Bayesian word-Recognition model with Attention, Interference and Dynamics. As most of its predecessors, BRAID incorporates three sensory, perceptual, and orthographic knowledge layers together with a lexical membership submodel.

Bathymetry of the Antarctic continental shelf and ice shelf cavities from circumpolar gravity anomalies and other data.

Bathymetry critically influences the intrusion of warm Circumpolar Deep Water onto the continental shelf and under ice shelf cavities in Antarctica, thereby forcing ice melting, grounding line retreat, and sea level rise. We present a novel and comprehensive bathymetry of Antarctica that includes all ice shelf cavities and previously unmeasured continental shelf areas. The new bathymetry is based on a 3D inversion of a circumpolar compilation of gravity anomalies constrained by measurements from the International Bathymetric Chart of the Southern Ocean, BedMachine Antarctica, and discrete seafloor measurements from seismic and ocean robotic probes.

Advanced Analysis of Clay Microporosity Using High-Resolution N-Ar Adsorption Isotherms Coupled with the Derivative Isotherm Summation Method.

The textural properties of synthetic and natural clays in the sodium form and exchanged with tetramethylammonium cations (TMA) were characterized using N and Ar physisorption isotherms at cryogenic temperatures. Specific surface areas and micro/mesoporous volumes were determined using the BET and the models. The analysis requires the use of reference isotherms measured at the same temperature on the surface of non-porous materials with an identical chemical composition.

Faithful interpretation of protein structures through weighted persistent homology improves evolutionary distance estimation.

Phylogenetic inference is mainly based on sequence analysis and requires reliable alignments. This can be challenging, especially when sequences are highly divergent. In this context, the use of three-dimensional protein structures is a promising alternative.

Digital Transformation of Rheumatology Care in Germany: Cross-Sectional National Survey.

Background: In recent years, health care has undergone a rapid and unprecedented digital transformation. In many fields of specialty care, such as rheumatology, this shift is driven by the growing number of patients and limited resources, leading to increased use of digital health technologies (DHTs) to maintain high-quality clinical care. Previous studies examined user acceptance of individual DHTs in rheumatology, such as telemedicine, video consultations, and mHealth.

Hypereosinophilia and Hypereosinophilic Syndromes: First Findings From a Nationwide Multicenter Cohort.

Background: Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available.

Methods: The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic HES [HES-L], neoplastic HE/HES [HE/HES-N], HE of unknown significance [HE-US], as well as IgG4-related disease [IgG4RD] or ANCA-negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps).

Formation and Evolution of the Solid Electrolyte Interphase on Silicon Electrodes from Fluorine-Free Electrolytes.

With the increasing attention to energy storage solutions, a growing emphasis has been placed on environmentally compatible electrolytes tailored for lithium-ion batteries. This study investigates the surface behavior of Si wafers as model systems cycled with a fluorine-free electrolyte based on lithium bis(oxalato)borate (LiBOB), with and without the additive vinylene carbonate (VC). By utilizing operando X-ray reflectivity (XRR) and ex situ X-ray photoelectron spectroscopy (XPS), the intricate processes involved in solid electrolyte interphase (SEI) formation is elucidated, SiO/Si (de)lithiation, and the impact of the VC additive.

Effectiveness of complement inhibitors against refractory antibody-mediated rejection of lung transplantation: Two clinical cases.

Antibody-mediated rejection (AMR) has been recognized as a significant cause of acute and chronic lung allograft dysfunction after lung transplantation. Some treatments, eculizumab, an anti-complement (C)5 component monoclonal antibody (Mab), seem to have a promising effect in the management of some patients with AMR. We present two patients with acute AMR after lung transplantation who received the anti-C5 Mab therapy.

Climate, not land-use, drives a recent acceleration of larch expansion at the forest-grassland ecotone in the southern French alps.

In recent decades significant forest expansion into treeless alpine zones has been observed across global mountain ranges, including the Alps, driven by a complex interplay of global warming and land-use changes. The upward shift of treelines has far-reaching implications for ecosystem functioning, biodiversity, and biogeochemical cycles. However, climate variables alone account for only a fraction of treeline dynamics, highlighting substantial research gaps concerning the influence of non-climatic factors.

Does the stop-signal P3 reflect inhibitory control?

The ability to stop already-initiated actions is paramount to adaptive behavior. In psychology and neuroscience alike, action-stopping is a popular model behavior to probe inhibitory control - the underlying cognitive control process that is purportedly vital to regulating thoughts and actions. Starting with seminal work in the 1990s, the frontocentral stop-signal P3 - an event-related potential derived from scalp EEG - has been proposed as a neurophysiological index of inhibitory control during action-stopping.

Accelerated aging modulates the toxicological properties of the diazo tattoo pigment PO13.

Pigment particles used in tattooing may exert long terms effect by releasing diffusible degradation products. In the present work, aqueous suspensions of the organic orange diazo pigment PO13 were aged by exposure to simulated sunlight at 40 °C. The morphology and the surface charge of PO13 particles were barely modified upon aging, but primary particles were released by de-agglomeration.