Self-Extracting Dextran-Based Hydrogel Microneedle Arrays with an Interpenetrating Bioelectroenzymatic Sensor for Transdermal Monitoring with Matrix Protection.

Continuous glucose monitors have revolutionized diabetes management, yet such devices are limited by their cost, invasiveness, and stability. Microneedle (MN) arrays could offer improved comfort compared to invasive implanted or mm-sized needle devices, but such arrays are hampered by complex fabrication processes, limited mechanical and sensor stability, and/or cytotoxicity concerns. This work demonstrates the first crosslinked hydrogel microneedle-bioelectroenzymatic sensor arrays capable of biomarker extraction and robust transdermal continuous monitoring in artificial interstitial fluid for 10 days.

Unusually large microporous HKUST-1 via polyethylene glycol-templated synthesis: enhanced CO uptake with high selectivity over CH and N.

Porous solids with highly microporous structures for effective carbon dioxide uptake and separation from mixed gases are highly desirable. Here we present the use of polyethylene glycol (20,000 g/mol) as a soft template for the simple and rapid synthesis of a highly microporous Cu-BTC (denoted as HKUST-1). The polyethylene glycol-templated HKUST-1 obtained at room temperature in 10 min exhibited a very high Brunauer-Emmett-Teller (BET) surface area of 1904 m/g, pore volume of 0.

Analysis of Phase Separation of EARLY FLOWERING 3.

Phase separation is an important mechanism for regulating various cellular functions. The EARLY FLOWERING 3 (ELF3) protein, an essential element of the EVENING COMPLEX (EC) involved in circadian clock regulation, has been shown to undergo phase separation. ELF3 is known to significantly influence elongation growth and flowering time regulation, and this is postulated to be due to whether the protein is in the dilute or phase-separated state.

A multimodal dynamical variational autoencoder for audiovisual speech representation learning.

High-dimensional data such as natural images or speech signals exhibit some form of regularity, preventing their dimensions from varying independently. This suggests that there exists a lower dimensional latent representation from which the high-dimensional observed data were generated. Uncovering the hidden explanatory features of complex data is the goal of representation learning, and deep latent variable generative models have emerged as promising unsupervised approaches.

Early picc-line infections in non-neutropenic patients are mainly due to E. coli suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy.

Purpose: To describe the rate of peripherally inserted central catheter (PICC) -associated bloodstream infections, and the pathogens involved.

Methods: We prospectively analyzed data collected from all adult patients with a PICC insertion in a hematology unit in a tertiary care center between January 1, 2017 and June 30, 2020.

Results: A total of 370 PICCs were inserted in 275 patients with hematological malignancies: 54 (15 %) confirmed cases of central-line associated bloodstream infection (CLABSI) were identified.

Controlling the Assembly of Cellulose-Based Oligosaccharides through Sequence Modifications.

Peptides and nucleic acids with programmable sequences are widely explored for the production of tunable, self-assembling functional materials. Herein we demonstrate that the primary sequence of oligosaccharides can be designed to access materials with tunable shapes and properties. Synthetic cellulose-based oligomers were assembled into 2D or 3D rod-like crystallites.

Chlorhexidine digluconate exerts bactericidal activity vs Gram positive Staphylococci with bioelectrocatalytic compatibility: High level disinfection for implantable biofuel cells.

Implanted devices destined for contact with sterile body tissues, vasculature or fluids should be free of any microbial contamination that could lead to disease transmission. The disinfection and sterilisation of implantable biofuel cells is a challenging and largely overlooked subject due to the incompatibility of fragile biocatalytic components with classical treatments. Here we report the development of a convenient "soft" chemical treatment based on immersion of enzymatic bioelectrodes and biofuel cells in dilute aqueous chlorhexidine digluconate (CHx).

Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells.

Implantable devices powered by batteries have been used for sixty years. In recent devices, lithium-based batteries are the most widely used power source. However, lithium batteries have many disadvantages in terms of safety, reliability, and longevity and require regular monitoring and substitution.

Year-round trace gas measurements in the central Arctic during the MOSAiC expedition.

Despite the key role of the Arctic in the global Earth system, year-round in-situ atmospheric composition observations within the Arctic are sparse and mostly rely on measurements at ground-based coastal stations. Measurements of a suite of in-situ trace gases were performed in the central Arctic during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition. These observations give a comprehensive picture of year-round near-surface atmospheric abundances of key greenhouse and trace gases, i.

Enhancing the incorporation of Sn in vapor-liquid-solid GeSn nanowires by modulation of the droplet composition.

We report on the influence of the liquid droplet composition on the Sn incorporation in GeSn nanowires (NWs) grown by the vapor-liquid-solid (VLS) mechanism with different catalysts. The variation of the NW growth rate and morphology with the growth temperature is investigated and 400 °C is identified as the best temperature to grow the longest untapered NWs with a growth rate of 520 nm min. When GeSn NWs are grown with pure Au droplets, we observe a core-shell like structure with a low Sn concentration of less than 2% in the NW core regardless of the growth temperature.

Effect of Chiral Damping on the dynamics of chiral domain walls and skyrmions.

Friction plays an essential role in most physical processes that we experience in our everyday life. Examples range from our ability to walk or swim, to setting boundaries of speed and fuel efficiency of moving vehicles. In magnetic systems, the displacement of chiral domain walls (DW) and skyrmions (SK) by Spin Orbit Torques (SOT), is also prone to friction.

Real-Time Quality Index to Control Data Loss in Real-Life Cardiac Monitoring Applications.

Wearable cardiac sensors pave the way for advanced cardiac monitoring applications based on heart rate variability (HRV). In real-life settings, heart rate (HR) measurements are subject to motion artifacts that may lead to frequent data loss (missing samples in the HR signal), especially for commercial devices based on photoplethysmography (PPG). The current study had two main goals: (i) to provide a white-box quality index that estimates the amount of missing samples in any piece of HR signal; and (ii) to quantify the impact of data loss on feature extraction in a PPG-based HR signal.

Review: Unaccompanied refugee minors' perception of mental health services and professionals: a systematic review of qualitative studies.

Background: Unaccompanied refugee minors (URMs) are a population at risk of mental health problems and a population with whom the therapeutic alliance can be difficult to set up. The therapeutic alliance's quality can impact the result and effectiveness of psychotherapeutic interventions. The aim of the present study was to gather URMs' points of view about mental health services and mental health professionals (MHP) in the host country.

Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in .

Three-dimensional eukaryotic genome organization provides the structural basis for gene regulation. In , genome folding is characterized by somatic homolog pairing, where homologous chromosomes are intimately paired from end to end; however, how homologs identify one another and pair has remained mysterious. Recently, this process has been proposed to be driven by specifically interacting 'buttons' encoded along chromosomes.

Clinical Relevance of Pharmacist Intervention: Development of a Named Entity Recognition Model on Unstructured Comments.

We developed a clinical named entity recognition model to predict clinical relevance of pharmacist interventions (PIs) by identifying and labelling expressions from unstructured comments of PIs. Three labels, drug, kidney and dosage, had a great inter-annotator agreement (>60%) and could be used as reference labelization. These labels also showed a high precision (>70%) and a variable recall (50-90 %).

Monofunctional pyrenes at carbon nanotube electrodes for direct electron transfer HO reduction with HRP and HRP-bacterial nanocellulose.

The non-covalent modification of carbon nanotube electrodes with pyrene derivatives is a versatile approach to enhance the electrical wiring of enzymes for biosensors and biofuel cells. We report here a comparative study of five pyrene derivatives adsorbed at multi-walled carbon nanotube electrodes to shed light on their ability to promote direct electron transfer with horseradish peroxidase (HRP) for HO reduction. In all cases, pyrene-modified electrodes enhanced catalytic reduction compared to the unmodified electrodes.

Controlled Heat and Humidity-Based Treatment for the Reuse of Personal Protective Equipment: A Pragmatic Proof-of-Concept to Address the Mass Shortage of Surgical Masks and N95/FFP2 Respirators and to Prevent the SARS-CoV2 Transmission.

The coronavirus infectious disease-2019 (COVID-19) pandemic has led to an unprecedented shortage of healthcare resources, primarily personal protective equipment like surgical masks, and N95/filtering face piece type 2 (FFP2) respirators. Reuse of surgical masks and N95/FFP2 respirators may circumvent the supply chain constraints and thus overcome mass shortage. Methods, design, setting, and measurement: Herein, we tested the effects of dry- and moist-air controlled heating treatment on structure and chemical integrity, decontamination yield, and filtration performance of surgical masks and FFP2 respirators.

Monitoring discharge in a tidal river using water level observations: Application to the Saigon River, Vietnam.

The hydrological dynamics of the Saigon River is ruled by a complex combination of factors, which need to be disentangled to prevent and limit risks of flooding and salt intrusion. In particular, the Saigon water discharge is highly influenced by tidal cycles with a relatively low net discharge. This study proposes a low-cost technique to estimate river discharge at high frequency (every 10 min in this study).

Photochromic dye-sensitized solar cells with light-driven adjustable optical transmission and power conversion efficiency.

Semi-transparent photovoltaics only allows for the fabrication of solar cells with an optical transmission that is fixed during their manufacturing resulting in a trade-off between transparency and efficiency. For the integration of semi-transparent devices in building, ideally solar cells should generate electricity while offering the comfort for users to self-adjust their light transmission with the intensity of the daylight. Here we report a photochromic dye-sensitized solar cell (DSSC) based on donor-π-conjugated bridge-acceptor structures where the π-conjugated bridge is substituted for a diphenyl-naphthopyran photochromic unit.

Push-Pull Zinc Phthalocyanine Bearing Hexa-Tertiary Substituted Carbazolyl Donor Groups for Dye-Sensitized Solar Cells.

An asymmetrical, push-pull phthalocyanine bearing bulky -butylcarbazolyl moieties as electron donor and carboxylic acid as anchoring group was synthetized and tested as a photosensitizer in dye-sensitized solar cells (DSSC). The new photosensitizer was characterized by 1H and 13C NMR, UV-Vis and mass spectrometry. The bulky -butylcarbazolyl moieties avoid the aggregation of the phthalocyanine dye.

Electric Field Control of Magnetism in Iron Oxide Nanoporous Thin Films.

Voltage control of the magnetic properties of oxide thin films is highly appealing to enhance energy efficiency in miniaturized spintronic and magnetoelectric devices. Herein, magnetoelectric effects in electrolyte-gated nanoporous iron oxide films are investigated. Highly porous films were prepared by the evaporation-induced self-assembly of sol-gel precursors with a sacrificial block-copolymer template.

Reversible, Electric-Field Induced Magneto-Ionic Control of Magnetism in Mesoporous Cobalt Ferrite Thin Films.

The magnetic properties of mesoporous cobalt ferrite films can be largely tuned by the application of an electric field using a liquid dielectric electrolyte. By applying a negative voltage, the cobalt ferrite becomes reduced, leading to an increase in saturation magnetization of 15% (M) and reduction in coercivity (H) between 5-28%, depending on the voltage applied (-10 V to -50 V). These changes are mainly non-volatile so after removal of -10 V M remains 12% higher (and H 5% smaller) than the pristine sample.