Are crystalloid-based fluid expansion strategies still relevant in the first hours of trauma induced hemorrhagic shock?

Background: Crystalloid-based fluid resuscitation has long been a cornerstone in the initial management of trauma-induced hemorrhagic shock. However, its benefit is increasingly questioned as it is suspected to increase bleeding and worsen coagulopathy. The emergence of alternative strategies like permissive hypotension and vasopressor use lead to a shift in early trauma care practices.

Multi-dimensional Dataset of Stress Measurements based on Performance, Behavioural, and Perceptual Indicators.

The role of humans in industry is changing due to the technological transformation of production processes, which represents a potential source of stress for workers. In this context, the NO-STRESS project aims to combine objective and subjective data collected during task execution to explore causes of work-related stress and propose solutions to mitigate them. This paper describes the within-subjects study design used in the project, where each participant was exposed to all experimental conditions, and outlines the workflow developed during the study.

Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data.

Obstructive sleep apnoea (OSA) contributes to cerebrovascular diseases and cognitive decline. Preclinical studies support the deleterious impact on the brain of intermittent hypoxia (IH), one of the main components of OSA, but heterogeneity in rodent species and brain regions studied, or induced by IH paradigms, can challenge interpretation of the studies. Hence, we conducted a systematic review and meta-analysis to evaluate the impact of IH on rodent brain oxidative stress, inflammation, apoptosis and the expression of brain-derived neurotrophic factor (BDNF) and hypoxia-inducible factor 1 (HIF-1).

Dynamic quinone repertoire accompanied the diversification of energy metabolism in Pseudomonadota.

It is currently unclear how Pseudomonadota, a phylum that originated around the time of the Great Oxidation Event, became one of the most abundant and diverse bacterial phyla on Earth, with metabolically versatile members colonizing a wide range of environments with different O2 concentrations. Here, we address this question by studying isoprenoid quinones, which are central components of energy metabolism covering a wide range of redox potentials. We demonstrate that a dynamic repertoire of quinone biosynthetic pathways accompanied the diversification of Pseudomonadota.

Acclimatized Lowlanders Exhibit a Hypocoagulable Profile after a Passive Ascent at High Altitude.

Stauffer, Emeric, François Caton, Raphael Marlu, Aurélien Pichon, Landry Seyve, Michael Furian, Aymeric Paillisser, Florence Berquet, Jeremy De Abreu, Blandine Deschamps, Benoit Polack, Philippe Connes, Paul Robach, Stéphane Doutreleau, Julien V Brugniaux, Samuel Verges, and Benoit Champigneulle.Acclimatized lowlanders exhibit a hypocoagulable profile after a passive ascent at high altitude. 00:00-00, 2024.

Review and experimental comparison of speckle-tracking algorithms for X-ray phase contrast imaging.

X-ray speckles have been used in a wide range of experiments, including imaging (and tomography), wavefront sensing, spatial coherence measurements, X-ray photon correlation spectroscopy and ptychography. In this review and experimental comparison, we focus on using X-ray near-field speckle grains as wavefront markers and numerical methods for retrieving the phase information they contain. We present the most common tracking methods, introducing the existing algorithms with their specifications and comparing their performances under various experimental conditions.

Circulating immune landscape in melanoma patients undergoing anti-PD1 therapy reveals key immune features according to clinical response to treatment.

Introduction: Immune checkpoint blockers (ICB) bring unprecedented clinical success, yet many patients endure immune mediated adverse effects and/or fail to respond. Predictive signatures of response to ICB and mechanisms of clinical efficacy or failure remain understudied. DC subsets, in network with conventional αβ T (T), NK, γδ T and iNKT cells, harbor pivotal roles in tumor control, yet their involvement in response to ICB remained underexplored.

Phosphorescent Chiral Cationic Binuclear Iridium(III) Complexes: Boosting the Circularly Polarized Luminescence Brightness.

We report the synthesis and characterization of two chiral binuclear iridium(III) complexes ( and ) prepared from enantiopure building blocks [μ-Cl(Δ-Ir(C^N))] and [μ-Cl(Λ-Ir(C^N))]. These building blocks have been obtained by chiral preparative high-performance liquid chromatography of the neutral iridium(III) complex (piv = 2,2,6,6-tetramethylheptane-3,5-dionate) followed by selective degradation of the ancillary ligand. For comparison purposes, we also synthesized a monomer () and a dimer (, mixture).

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD.

With antimicrobial resistance (AMR) reaching alarming levels, new anti-infectives with unprecedented mechanisms of action are urgently needed. The 2-C-methylerythritol-D-erythritol-4-phosphate (MEP) pathway represents an attractive source of drug targets due to its essential role in numerous pathogenic Gram-negative bacteria and Mycobacterium tuberculosis (Mt), whilst being absent in human cells. Here, we solved the first crystal structure of Pseudomonas aeruginosa (Pa) IspD, the third enzyme in the MEP pathway and present the discovery of a fragment-based compound class identified through crystallographic screening of PaIspD.

Sub-minimum inhibitory concentrations in ceftazidime exacerbate the formation of Acinetobacter baumannii biofilms.

Associated with nosocomial infections, the environmental Gram-negative coccobacillus A. baumannii leads to various kinds of high mortality-rate infections among which pneumonias mainly in immune-compromised people from health-care facilities. A critical component of the current antibiotic resistance problem is the presence of antibiotics sub-minimum inhibitory concentrations (sub-MICs) in a variety of natural settings including drinking water, sewage water, rivers, lakes, and natural sludge.

Induction triplet chemotherapy in patients with rectal adenocarcinoma and synchronous metastases, an AGEO-FFCD study.

Aim Of The Study: The management of synchronous metastatic rectal cancer (SMRC) is complex and multimodal, involving chemotherapy, surgery and/or radiotherapy. The aim of this study was firstly to confirm the efficacy of the induction FOLFIRINOX, and secondly to evaluate the different therapeutic strategies and outcomes of patients.

Patients And Methods: This French study combined data from a prospective FFCD trial and a multicenter cohort.

A medical profession towards empowerment? The uncertain future of digitalization in private general practice.

The aim of the paper is to understand what drives private general practitioners (GPs) to introduce digital technologies, and to use them extensively. While prior research has highlighted barriers to adoption for practitioners when digital tools are introduced by managers and policy makers, we explore how GPs having their own practice introduce digital innovation and how they integrate them into their practices. Our qualitative study focuses on liberal emergency medicine in France, providing a unique context to examine how GPs at the front lines of health system failures and changes introduce and adopt digital technologies.

Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure.

Influenza A viruses are responsible for human seasonal epidemics and severe animal pandemics with a risk of zoonotic transmission to humans. The viral segmented RNA genome is encapsidated by nucleoproteins (NP) and attached to the heterotrimeric polymerase, forming the viral ribonucleoproteins (vRNPs). Flexible helical vRNPs are central for viral transcription and replication.

Early-life exposures to phenols, parabens and phthalates and fat mass at 3 years of age in the SEPAGES cohort.

Background: Early-life exposure to short half-life chemicals may influence adiposity growth, a precursor to obesity. Previous studies often relied on limited urine samples that inadequately represent exposure during pregnancy or infancy. Additionally, childhood adiposity is commonly estimated using body mass index, which does not accurately reflect body composition.

ADHD and alcohol: Emotional regulation efforts pay off in quality of life points.

The emotion dysregulation and impulsivity are highly associated with alcohol use disorder (AUD). This study explored the role of impulsivity and emotion dysregulation and the interaction with adult probable ADHD on alcohol-related quality of life (QoL). In this observational trial, we analyzed data from the randomized TRAIN study, which compared efficacy of two cognitive training programs in patients AUD recently detoxified at 5 centers in France from February 2019 to February 2023, and who completed child and adult ADHD screening data (WURS + ARSR, n = 206 of 226).

Coexistence of room temperature magneto-chiral dichroism and magneto-electric coupling in a chiral nanomagnet.

We report herein on the magneto-chiral dichroism (MChD), investigated through near infrared light absorption, of a chiral nanomagnet showing room temperature magneto-electric coupling. The MChD signal associated with the Yb center is driven by the magnetic dipole allowed character of the F ← F electronic transition (|Δ| = 1). Magnetic field and temperature dependence studies reveal an MChD signal that follows the material magnetization and persists at room temperature.

Click-ready iridium(iii) complexes as versatile bioimaging probes for bioorthogonal metabolic labeling.

Herein, we report the synthesis, photophysical characterization and validation of iridium(iii)-polypyridine complexes functionalized for click chemistry and bioorthogonal chemistry, as well as their versatile applications as probes in bioimaging studies exploiting metabolic labeling. The designed dyes are conjugated to chemical reporters in a specific manner within cells by CuAAC ligation and display attractive photophysical properties in the UV-visible range. They are indeed highly photostable and emit in the far-red to near-IR region with long lifetimes and large Stokes shifts.

Growth of Silver Nanoparticles into Reducing-End Carbohydrate-Based Supramolecular Hydrogels for Antimicrobial Applications.

Hydrogels with antibacterial activities have the potential for many biomedical applications, such as wound healing, because of their capacity to maintain a moist environment and prevent infections. In this work, an ultrasound-induced supramolecular hydrogel consisting of easily accessible reducing-end-free glucosaminylbarbiturate-based hydrogelators that serve the fabrication of silver nanoparticles (AgNPs), excluding the addition of any external reducing or stabilizing agents, has been developed. The innovative synthetic approach relied on the use of -disubstituted barbituric acid derivatives as a versatile chemical platform that site-selectively reacted with the amino function of glucosamine.

Shaping tomorrow: how the STEP training course pioneered noninvasive brain stimulation training for psychiatry in France.

Over the past three decades, non-invasive brain stimulation (NIBS) techniques have gained worldwide attention and demonstrated therapeutic potential in various medical fields, particularly psychiatry. The emergence of these novel techniques has led to an increased need for robust training programs to provide practitioners, whether clinicians or scientists, with the necessary skills and knowledge. In response, a comprehensive training curriculum for NIBS in psychiatry has been developed in France.

Electrospinning of methacrylated alginate for tissue engineering applications.

Photo-crosslinkable methacrylated alginate derivatives (M-ALGs) were synthesized modification of sodium alginate with glycidyl methacrylate. Needle (capillary) and needleless electrospinning techniques were employed to produce their nonwoven fiber mats. Spinning parameters such as applied voltage, solution composition, and flow rate were optimized to form uniform bead-free fibers with an average diameter of about 150 nm.

Early auditory impairments as a candidate marker of attenuated sensory symptoms of psychosis.

Background And Hypothesis: Deficits in early auditory processing (EAP), as indexed by tone-matching performance, have been consistently demonstrated in individuals with schizophrenia spectrum disorders. However, the ontogeny of tone-matching deficits in schizophrenia remains relatively unknown. The current study aims to determine the relationship between clinical high risk for psychosis and EAP.

Why does tinnitus vary with naps? A polysomnographic prospective study exploring the somatosensory hypothesis.

Background: Tinnitus, defined as the conscious awareness of a noise without any identifiable corresponding external acoustic source, can be modulated by various factors. Among these factors, tinnitus patients commonly report drastic increases of tinnitus loudness following nap sleep. Previous studies have suggested that this clinical pattern could be attributed to a somatosensory modulation of tinnitus.