Comparison of baroreflex sensitivity measures for assessing subjects with obstructive sleep apnea.

Baroreflex sensitivity (BRS) is assessed in subjects with and without obstructive sleep apnea (OSA) using the time domain direct sequence technique, the spectral transfer function (TF) technique and the alpha index technique. All three measures showed a significantly depressed BRS value in subjects with severe apnea. The high frequency (HF) component of the spectral measures showed higher correlation with the sequence technique measures than the low frequency (LF) component.

A spectrum of colors: investigating the temporal frequency characteristics of the human visual system using a system identification approach.

Noise input signals are commonly used in both linear and nonlinear system identification of physiological systems. This method can be applied to electrophysiological analysis of the human visual system by controlling the modulation of the contrast of a checkerboard stimulus using a pre-computed noise waveform. In this study we describe how one can obtain an estimate of the linear impulse response of the visual system using noise waveforms.

Multi-channel EEG based neonatal seizure detection.

A multi-channel method for patient specific and patient independent, EEG based neonatal seizure detection is presented. Two classifier configurations are proposed and tested, along with a number of classifier models. Existing methods for neonatal seizure detection have been empirical threshold based or based on a single EEG channel.

Jund activates transcription through multiple gres in the absence of active glucocorticoid receptor.

Transcription factor AP-1 and the glucocorticoid receptor activate gene expression through interaction with specific DNA elements located in the promoter/enhancer region of responsive genes. Recently, it was reported that AP-1 and the glucocorticoid receptor are able to mutually repress each others transcriptional activity. Both, Fos and Jun consist of small families of genes coding for structurally related proteins.

Evaluation of the antineoplastic activities of the riminophenazine agents clofazimine and b669 in tumor-bearing rats and mice.

The riminophenazine agents clofazimine and its analogue B669 displayed anti-tumor activity at 30 mg/kg/day in benzo[a]pyrene (BP) induced sarcomas of mice as well as dimethylbenz-anthracene (DMBA)-induced rat mammary tumors. No hematological toxicity of these drugs at doses up to 60 mg/kg/day for one month was observed. This is the first study to document in vivo anti-neoplastic activities of clofazimine and B669.