Polystyrene nanoplastics impact the bioenergetics of developing zebrafish and limit molecular and physiological adaptive responses to acute temperature stress.

Plastic pollution is a growing environmental concern due to its ubiquitous impact on aquatic ecosystems. Nanoplastics can be generated from the breakdown of plastic waste and interact with organisms at the cellular level, potentially disrupting cellular physiology. We investigated the effects of 44 nm polystyrene nanoparticles (44 nm NanoPS) on the development and physiology of zebrafish (Danio rerio) in the presence of sublethal heat stress (32 °C vs control, 28 °C).

[Becoming an occupational health nurse].

Since March 2023, occupational health nurses have been required to have a professional license, a master's degree or an inter-university diploma. They are required to take over 200 hours of theoretical courses, and to complete one or more internships equivalent to over 100 hours.

Comprehensive analysis of supervised learning methods for electrical source imaging.

Electroencephalography source imaging (ESI) is an ill-posed inverse problem: an additional constraint is needed to find a unique solution. The choice of this constraint, or prior, remains a challenge for most ESI methods. This work explores the application of supervised learning methods for spatio-temporal ESI, where the relationship between measurements and sources is learned directly from the data.

Radiological anatomical measurements of the superficial temporal artery: an interobserver reproducibility study.

Purpose: Numerous studies have already reported on the anatomy of the superficial temporal artery (STA) on dissection or imaging, and more specifically on CT angiography. However, few studies have reported on the possible variations that exist between readers in the assessment of certain anatomical parameters. The aim of this study was to investigate the reproducibility of different anatomical measurements of the superficial temporal artery with CT angiography.

Harnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities.

Monoterpene indole alkaloids (MIAs) are valuable metabolites produced in numerous medicinal plants from the Apocynaceae family such as Alstonia scholaris, which synthesizes strictamine, a MIA displaying neuropharmacological properties of a potential importance. To get insights into the MIA metabolism in A. scholaris, we studied here both the spatial and transcriptional regulations of MIA genes by performing a robust transcriptomics analysis of the main plant organs, leaf epidermis but also by sequencing RNA from leaves transiently overexpressing the master transcriptional regulator MYC2.

Gonyaulax montresoriae sp. nov. (Dinophyceae) from the Adriatic Sea produces predominantly yessotoxin.

Yessotoxin is one of the shellfish toxins leading to mussel farm closures in the Adriatic Sea of Italy. Two putative Gonyaulax spinifera strains GSA0501 and GSA0602 are known as yessotoxins producers, but their identities have remained elusive since 2005. To address this gap, we established five Gonyaulax strains by incubating sediments from the Adriatic Sea and subsequently isolating single cells.

Dissemination of antibiotic-resistant bacteria associated with microplastics collected from Monastir and Mahdia coasts (Tunisia).

The exponential use of plastics and their recalcitrant nature leads to their significant accumulation in the environment. The occurrence of plastic wastes is considered as a serious environmental problem. Additionally, plastic wastes can break down into smaller pieces called microplastics (MPs), leading to further interactions with the environment and living organisms.

Trace element uptake by macroalgae: Organic colloids as a source of metals, including Fe and rare earth elements.

We determined the concentrations of trace elements including Fe, Al, rare earth elements and Y (REY), in Ascophyllum nodosum, one of the most abundant brown macroalgae in the North Atlantic. Samples were collected in the Bay of Brest (Brittany, France) and in the estuary of its main contributing river. The Y/Ho, Al/Ga, and Zr/Hf ratios display values distinctive from seawater, but similar to the continental crust; an observation which we show cannot be explained by the incorporation of terrigenous particles, nor inorganic colloids.

Different metabolite profiles across Penicillium roqueforti populations associated with ecological niche specialisation and domestication.

Fungi are known to produce many chemically diversified metabolites, yet their ecological roles are not always fully understood. The blue cheese fungus Penicillium roqueforti thrives in different ecological niches and is known to produce a wide range of metabolites, including mycotoxins. Three P.

Upconversion Luminescence with Bis-pyclen Yb(III) Chelates: Crown vs. Linear Polyether Linkers in Discrete Heteropolynuclear Architectures.

Ligands combining two lateral bis-pyridyl-phosphonated-pyclens were synthesized, using a flexible linear pegylated linker (L2) or a bulkier K22 crown-ether (L3). A functionalized pyridyl-phosphonated-pyclen (L1) was also prepared as a mononuclear analogue. Coordination behavior of lanthanide cations was studied via NMR titration with Lu for L1, and UV/Vis and luminescence spectroscopy with Yb for L2/L3.

[Between the normal and the pathological: The concept of pre-disease applied to systemic autoimmune rheumatic diseases].

The incidence of systemic autoimmune diseases is constantly rising. They are chronic diseases requiring prolonged treatment, with considerable psychosocial impact. While attention to the promising results obtained with CAR-T cells in refractory patients is justified, it seems important not to overlook the opportunities for prevention based on the identification of a pre-disease state.

In situ oil contamination in young mangroves: Biodegradation of petroleum hydrocarbons and effects on the microbial and benthic communities, an experimental study in French Guiana.

An in-situ experiment was conducted in a young mangrove with no history of oil contamination (French Guiana). Control and oil-contaminated sediments were sampled one month after exposure and analyzed to a depth of 18 cm to assess natural oil depletion and changes in benthic communities. High biodegradation percentages (89-99 %) of n-alkanes and polycyclic aromatic hydrocarbons were measured.

Loss of tissue-type plasminogen activator causes multiple developmental anomalies.

Hydrocephalus and Dandy-Walker malformation are amongst the most common congenital brain anomalies. We identified three consanguineous families with both obstructive hydrocephalus and Dandy-Walker malformation. To understand the molecular basis of these anomalies, we conducted genome-wide sequencing in these families.

Active disturbance rejection control for four-wire inverters in standalone renewable resources-based microgrid - islanded microgrids ADRC-based control.

This paper presents an active disturbance rejection control (ADRC) approach for three-phase four-legs voltage source inverters (FL-VSIs) in a standalone renewable energy resources (RES)-based islanded microgrid. The key purpose of the proposed approach is to improve the control robustness against load-side disturbances, power supply parameters uncertainties, and faulty operating conditions. Indeed, a notable benefit of ADRC is its ability to operate effectively without the need for precise knowledge of disturbance characteristics or accurate modeling and FL-VSI parameters.

Symbiont Acquisition Strategies in Post-Settlement Stages of Two Co-Occurring Deep-Sea Shrimp.

At deep-sea hydrothermal vents, deprived of light, most living communities are fueled by chemosynthetic microorganisms. These can form symbiotic associations with metazoan hosts, which are then called holobionts. Among these, two endemic co-occurring shrimp of the Mid-Atlantic Ridge (MAR), and are colonized by dense and diversified chemosynthetic symbiotic communities in their cephalothoracic cavity and their digestive system.

Exploring transformer reliability in clinically significant prostate cancer segmentation: A comprehensive in-depth investigation.

Despite the growing prominence of transformers in medical image segmentation, their application to clinically significant prostate cancer (csPCa) has been overlooked. Minimal attention has been paid to domain shift analysis and uncertainty assessment, critical for safely implementing computer-aided diagnosis (CAD) systems. Domain shift in medical imagery refers to differences between the data used to train a model and the data evaluated later, arising from variations in imaging equipment, protocols, patient populations, and acquisition noise.

Structural analysis of an Asterias rubens peptide indicates the presence of a disulfide-directed β-hairpin fold.

Sea stars are an abundant group of marine invertebrates that display remarkably robust regenerative capabilities throughout all life stages. Numerous proteins and peptides have been identified in a proteome study on the coelomic fluid (biofluid) of the common sea star Asterias rubens, which appear to be involved with the wound-healing response in the organism. However, the three-dimensional structure and function of several of these injury-responsive peptides, including the peptide KASH2, are yet to be investigated.

Behind the mask: Attentional focus and coping strategies of elite level fencers.

This study aimed to identify attentional foci and coping strategies of elite fencers during competitive matches, explore the co-occurrences between both, and examine their impact on performance. Twenty-two epeeists (11 males and 11 females) from a national team took part in self-confrontation interviews during two simulated tournaments. Data were analysed using inductive and deductive content analyses.

Synchronous motion of the Easter mantle plume and the East Pacific Rise.

The Easter mantle plume has produced one of the longest hotspot tracks in the Pacific Ocean. While previous studies have focused on the eastern side extending across the Nazca Plate, we use Ar/Ar isotopic and geochemical data to investigate the less explored western side around the Easter Microplate. We propose a dynamic model in which a deeper (600 km-depth), less buoyant mantle exerts a westward force on the East Pacific Rise (EPR), while a more buoyant plume region drives Easter hotspot volcanism and a localised acceleration in seafloor spreading.

Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor.

Thank to their particular pharmacokinetics, the use of small organic molecules can be a very promising alternative to macromolecular targeting biomolecules (i.e. antibodies, peptides…) for specific imaging of tumours.

Top 10+1 indicators for assessing forest ecosystem conditions: A five-decade fragmentation analysis.

Globally, land use change has consistently resulted in greater losses than gains in aboveground biomass (AGB). Forest fragmentation is a primary driver of biodiversity loss and the depletion of natural capital. Measuring landscape characteristics and analyzing changes in forest landscape patterns are essential for accounting for the contributions of forest ecosystems to the economy and human well-being.

Identification of the central tolerance checkpoint for autoreactive proteinase 3 B cells in human bone marrow.

Major target antigens of ANCA-associated vasculitis (AAV) are myeloperoxidase (MPO) and proteinase 3 (PR3). High-affinity MPO- and PR3-ANCA immunoglobulins are produced by antigen-experienced, class-switched autoreactive B cells. To prevent autoreactivity, B cells are subjected to several self-tolerance checkpoints, from the early immature stages in the bone marrow (BM), collectively called "central tolerance", to late mature stages, collectively called "peripheral tolerance"; the latter was recently elucidated for autoreactive PR3 B cells.