2 results match your criteria: "United States. Electronic address: jennifer.dorth@uhhospitals.org.[Affiliation]"

Chemoradiotherapy-related carotid artery inflammation in head and neck cancer patients quantified by [F]FDG PET/CT.

Oral Oncol

June 2019

Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, United States. Electronic address:

Objectives: Radiotherapy (RT) is associated with an increased risk of cardiovascular disease (CVD), but little is known about the mechanism for vascular injury and methods for early detection.

Materials And Methods: We conducted a prospective, pilot study of carotid artery inflammation using F-labeled 2-fluoro-2-deoxy-d-glucose ([F]FDG) PET/CT imaging pre- and 3 months post-RT in head-and-neck cancer (HNC) patients. [F]FDG uptake by the carotid arteries was measured by the maximum and mean target to background ratio (TBR, TBR) and the mean partial volume corrected standardized uptake value (pvcSUV).

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Purpose: To compare, using a cost-effectiveness analysis, the quality-adjusted life expectancy (QALE) and cost between the 2 treatment options for intermediate- to high-risk prostate cancer: (1) radiation (RT) with androgen deprivation therapy (ADT) or (2) radical prostatectomy (RP) followed by adjuvant RT for patients with risk factors.

Methods And Materials: Our Markov model allowed patients to transition between health states with yearly probabilities of developing cancer recurrence and/or toxicity. Probabilities were assigned according to favorable intermediate, unfavorable intermediate, or high-risk prostate cancer groups.

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