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Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases.

Clin Biochem

July 2023

Tufts Medical Center, 800 Washington St., Box 238, Boston, MA 02111, United States; Tufts Medical Center, 800 Washington St., Box 115, Boston, MA 02111, United States. Electronic address:

It has become commonplace to assume that nucleic acid amplification tests (NAATs) represent the gold standard for all infectious disease diagnostic testing. This proposition has become increasingly entrenched recently, as these tests can now be done, in comparison to even just a few years ago, relatively inexpensively and with rapid analytic turnaround times. Many can even be performed at the point of care by individuals without technical backgrounds.

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