2 results match your criteria: "United States. Electronic address: author@university.edu.[Affiliation]"
Halogenase engineering and its utility in medicinal chemistry.
Bioorg Med Chem Lett
June 2018
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, United States; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:
Halogenation is commonly used in medicinal chemistry to improve the potency of pharmaceutical leads. While synthetic methods for halogenation present selectivity and reactivity challenges, halogenases have evolved over time to perform selective reactions under benign conditions. The optimization of halogenation biocatalysts has utilized enzyme evolution and structure-based engineering alongside biotransformation in a variety of systems to generate stable site-selective variants.
View Article and Find Full Text PDFHigh expression of integrin αvβ3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors.
Bioorg Med Chem
May 2018
University of Notre Dame, 236 Nieuwland Science Hall, Notre Dame, IN 46545, United States. Electronic address:
The cell line OVCAR-4 was recently ranked as one of the most representative cell lines for high grade serous ovarian cancer (HGSOC). However, little work has been done to assess the susceptibility of OVCAR-4 cells and tumors to the more common types of molecular targeting. Proteome profiles suggest OVCAR-4 express high levels of integrin αvβ3 receptors.
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