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Double-blind, placebo-controlled trial of pioglitazone for bipolar depression.

J Affect Disord

February 2019

Department of Psychiatry, Mood Disorders Program, University Hospitals Cleveland Medical Center/Case Western Reserve University, 10524 Euclid Avenue, 12th Floor, Cleveland, OH, 44106, United States. Electronic address:

Background: Objective of the present study was to conduct an 8-week double-blind, randomized, placebo-controlled trial to test the efficacy of pioglitazone in the treatment of bipolar depression.

Methods: 38 outpatients with bipolar disorder and current major depressive episode were randomized to pioglitazone (15-45 mg/day) or placebo. The use of concomitant mood stabilizers, antipsychotics, and antidepressants was permitted.

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