stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments.

Introduction: Tuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. However, this diverse modeling panorama may lack consistency, limiting result comparability.

Cross-cutting effect of type 2 diabetes on the sensorimotor control of balance.

Type 2 Diabetes is a highly prevalent chronic disorder that affects multiple systems through microvascular complications. Complications such as diabetic peripheral neuropathy, diabetic retinopathy, and diabetic vestibular dysfunction (vestibulopathy) all directly interfere with the sensory components of balance and postural stability. The resulting impairments cause increased falls risk and instability, making it difficult to perform daily task or exercise.

Analytical sensitivity factors from distributions of time of flight of photons for near-infrared spectroscopy studies in multilayered turbid media.

Significance: In the last years, time-resolved near-infrared spectroscopy (TD-NIRS) has gained increasing interest as a tool for studying tissue spectroscopy with commercial devices. Although it provides much more information than its continuous wave counterpart, accurate models interpreting the measured raw data in real time are still lacking.

Aim: We introduce an analytical model that can be integrated and used in TD-NIRS data processing software and toolkits in real time.

Effects of cold storage on double integrating sphere optical property measurements of porcine dermis and subcutaneous fat from 400 to 1100 nm.

Significance: Accurate values of skin optical properties are essential for developing reliable computational models and optimizing optical imaging systems. However, published values show a large variability due to a variety of factors, including differences in sample collection, preparation, experimental methodology, and analysis.

Aim: We aim to explore the influence of storage conditions on the optical properties of the excised skin from 400 to 1100 nm.

Validation framework for digital measures.

The adoption of digital measures in pharmaceutical research and development (R&D) presents an opportunity to enhance the efficiency and effectiveness of discovering and developing new therapeutics. For clinical measures, the Digital Medicine Society's (DiMe) V3 Framework is a comprehensive validation framework that encompasses verification, analytical validation, and clinical validation. This manuscript describes collaborative efforts to adapt this framework to ensure the reliability and relevance of digital measures for a preclinical context.

Social determinants of financial stress and association with psychological distress among young adults 18-26 years in the United States.

Introduction: Financial stress (FS) during young adulthood may have lasting effects on financial security, physical health, and overall wellbeing. This study examines the burden, social determinants and mental health consequences of experienced FS among young adults in the United States, based on objective measures of financial stress.

Methods: We studied young adults aged 18-26 years using pooled data from the 2013-18 National Health Interview Survey.

Community acceptance of services and effectiveness of health camps in high-risk areas of Karachi, Sindh, Pakistan, 2021.

Introduction: Health camps are organized to provide basic health services in underprivileged communities. This study was conducted to determine community acceptance and effectiveness of health camps in the high-risk areas for the polio program in Karachi, Pakistan.

Methods: This cross-sectional survey was conducted at the health campsites in high-risk union councils (HRUCs) of four districts of Karachi, Sindh.

Development of a statewide network hub for screening, referral, and enrollment into food as medicine programs across Kentucky.

Unlabelled: Widespread recognition of food as medicine interventions' role in reducing food insecurity and improving health outcomes has recently emerged. Several states have released In Lieu of Services, state-approved alternative services that may be offered by managed care organizations in place of covered benefits, or 1,115 Medicaid waivers, which may allow for expanded nutrition services to reduce food insecurity and improve health outcomes. However, there are significant gaps in understanding how to create a statewide system for delivering "healthcare by food" interventions.

Types and cost of wellness services provided by a neighborhood-based academic nursing center.

Background: Despite increased insurance coverage since 2010, racial and ethnic minorities in the United States still receive less medical care than White counterparts. The Johns Hopkins School of Nursing's Center for Community Programs, Innovation, and Scholarship (COMPASS Center) provides free wellness services, aiming to address healthcare disparities in the neighborhoods.

Objective: To delineate the types and cost of wellness services provided by the COMPASS Center.

Global burden of pneumoconiosis attributable to occupational particulate matter, gasses, and fumes from 1990~2021 and forecasting the future trends: a population-based study.

Background: This study aimed to quantify the global impact of pneumoconiosis resulting from occupational exposure to particulate matter, gasses, and fumes from 1990 to 2021, utilizing data from the Global Burden of Disease Study 2021.

Method: The analysis evaluated the global, regional, and national burden of pneumoconiosis attributable to workplace exposure to particulate matter, gasses, and fumes. It explored variations in disease impact across different demographics, including age and gender, and analyzed the relationship between disease burden and the Socio-Demographic Index (SDI).

Design of the (FRESH) study: leveraging systems science to work with independently-owned restaurants to increase access to and promotion of healthful foods.

Background: High dietary quality can protect against diet-related chronic diseases. In the United States, racial and ethnic minorities and those with lower incomes consistently exhibit lower dietary quality. Independently-owned restaurants are a common prepared food source in minority low-income communities, but there are significant knowledge gaps on how to work with these restaurants to offer healthy food, due to underlying and dynamic complexities associated with providing healthy food options.

Vanishing twins, selection , and infant mortality in the United States.

Background And Objectives: Research to identify fetal predictors of infant mortality among singletons born in the United States (US) concludes that poorly understood and unmeasured "confounders" produce a spurious association between fetal size and infant death. We argue that these confounders include Vanishing Twin Syndrome (VTS)-the clinical manifestation of selection against frail male twins . We test our argument in 276 monthly conception cohorts conceived in the US from January 1995 through December 2017.

Preoperative pulmonary function is associated with left ventricular assist device outcomes.

Introduction: Although left ventricular assist device (LVAD) implantation is associated with improved survival in patients with end-stage heart failure, the impact of preoperative pulmonary function on short-term outcomes is unclear.

Methods: We conducted a retrospective review of all primary LVAD implants at a single institution. Common measures of preoperative pulmonary function were evaluated.

Indications and outcomes of liver transplantation for liver tumors in the United States.

Background: While hepatocellular carcinoma (HCC) remains the leading cause of liver transplant (LT) for liver tumors, indications have broadened over the years. Data regarding patient characteristics and outcomes of LT for liver tumors are limited.

Methods: From Jan-2002 to March-2022, 14,406 LT recipients for various liver tumors were identified in United Network for Organ Sharing database.

The pulmonary contusion score: Development of a simple scoring system for blunt lung injury.

Background: Pulmonary contusions (PC) are common after blunt chest trauma and can be identified with computed tomography (CT). Complex scoring systems for grading PC exist, however recent scoring systems rely on computer-generated algorithms that are not readily available at all hospitals. We developed a scoring system for grading PC to predict the need for prolonged mechanical ventilation and initial hospital admission location.

Discovering topics and trends in biosecurity law research: A machine learning approach.

This study employed machine learning techniques, specifically Latent Dirichlet Allocation (LDA), to analyze 559 articles on biosecurity legislation from 1996 to 2023. The LDA model identified nine key research topics, including Agricultural Management and Production, Biosafety and Environmental Impact, Biological Invasion and Regulation, Biosecurity Legislation and Prevention, Agriculture and Environmental Relations, Virus Infection and Governance, Health Risk Assessment and Detection, Disease Prevention and Biotechnology, and Policy Control and Research. The findings reveal significant trends: an increasing focus on Biosecurity Legislation and Prevention and a declining interest in Agricultural Management and Production.

Testing the relationships of hope and negotiable fate with sleep quality among university students in Hong Kong.

For university students, who are often under significant stress to perform well, sleep is particularly important, playing roles in learning and academic performance. Research demonstrates a relationship between hope and sleep quality. However, most work concerns Western samples, and the hope construct has been criticized for a Western bias.

Association between the Taq1A polymorphism and problematic media use in preadolescent children.

Objective: Problematic media use (PMU) is addiction-like media use. No study has examined if genetic factors for addiction relate to PMU during childhood. This study tested the association between genetic risk factors for addiction and PMU among 9-to-12-year-olds.

Post-training breakdown: acute effects of different training types on body hydration status and performance.

Objective: Wrestling is a complex sport that requires a combination of strength, endurance, and wrestling-specific technical training. Endurance activities, such as running, are commonly performed for rapid weight reduction before competition. However, these activities can severely disrupt recovery and lead to significant declines in performance.

Where do "chemical imbalance" beliefs come from? Evaluating the impact of different sources.

Introduction: Although the etiology of depression is incredibly complex, the narrative that it is caused by a simple "chemical imbalance" persists in lay settings. We sought to understand where people are exposed to this explanation (i.e.

Assessing self-determined motivation for drinking alcohol via the Comprehensive Relative Autonomy Index for Drinking.

Introduction: Self-Determination Theory (SDT) examines human motivation in multiple domains; however, the only existing measure assessing SDT-informed behavioral regulations for drinking focuses on responsible drinker behaviors, rather than drinking , which is important given the alignment between SDT and harm reduction approaches to alcohol use. The aim of this study was to test the structural validity of the SDT-informed Comprehensive Relative Autonomy Index for Drinking (CRAI-Drinking) among college students.

Methods: Participants included two convenience samples with a total of 630 adult drinkers (M = 21.