3 results match your criteria: "United States Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS)[Affiliation]"
Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders.
J Acquir Immune Defic Syndr
April 2017
*Hawaii Center for AIDS, University of Hawaii, Honolulu, HI;†Division of Neurology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand;‡Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA;§SEARCH, Thai Red Cross AIDS Research Center, Bangkok, Thailand;‖US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD;¶Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD;#Biostatistics and Data Management Core, University of Hawaii, Honolulu, HI; and**Department of Retrovirology, US Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand.
Article Synopsis
- - Monocytes may contribute to HIV-associated neurocognitive disorder (HAND) by transporting HIV to the brain and releasing inflammatory cytokines, impacting cognitive function.
- - A study found that levels of interleukin-8 and monocyte chemoattractant protein-1 were significantly higher in HAND patients compared to those with normal cognition, both at the start and after one year of antiretroviral therapy.
- - Higher cytokine levels correlated with the amount of HIV DNA in monocytes, indicating that both the size of HIV reservoirs and monocyte inflammatory responses play a role in the persistence of HAND.
Causal prophylactic efficacy of primaquine, tafenoquine, and atovaquone-proguanil against Plasmodium cynomolgi in a rhesus monkey model.
J Parasitol
October 2014
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910; * Department of Veterinary Medicine, United States Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand 10400. Correspondence should be sent to:
Since the 1940s, the large animal model to assess novel causal prophylactic antimalarial agents has been the Plasmodium cynomolgi sporozoite-infected Indian-origin rhesus monkey. In 2009 the model was reassessed with 3 clinical standards: primaquine (PQ), tafenoquine (TQ), and atovaquone-proguanil. Both control monkeys were parasitemic on day 8 post-sporozoite inoculation on day 0.
View Article and Find Full Text PDFCorrelation of protection against Japanese encephalitis virus and JE vaccine (IXIARO(®)) induced neutralizing antibody titers.
Vaccine
August 2011
Department of Veterinary Medicine, United States Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand.
Immune sera from volunteers vaccinated in a blinded Phase 3 clinical trial with JE-VAX(®) and a new Japanese encephalitis virus (JEV) vaccine (IC51 or IXIARO), were tested for the ability to protect mice against lethal JEV challenge. Sera from IXIARO vaccinated subjects were pooled into four batches based on neutralizing antibody measured by plaque reduction neutralization test (PRNT(50) titer): high (∼200), medium (∼40-50), low (∼20) and negative (<10). Pooled sera from JE-VAX(®) vaccinated subjects (PRNT(50) titer∼55) and pooled JEV antibody negative pre-vaccination sera were used as controls.
View Article and Find Full Text PDF