5,145,367 results match your criteria: "United States; University of South Florida[Affiliation]"
Lancet
January 2025
Francis I Proctor Foundation, University of California San Francisco, San Francisco, CA, USA; Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA; Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.
Background: Adalimumab is an effective treatment for juvenile idiopathic arthritis-associated uveitis. Data are scarce on the effects of discontinuing adalimumab after control of the disease had been reached. We aimed to assess efficacy and safety of discontinuing treatment in patients with juvenile idiopathic arthritis-associated uveitis.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
February 2025
AgenT, 4 rue Pierre Fontaine, 91000 Evry-Courcouronnes, France. Electronic address:
J Prev Alzheimers Dis
February 2025
Department of Health Behavior and Health Equity, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, United States.
Background: Alzheimer's disease and related dementias (ADRD) are chronically underdiagnosed in the U.S., particularly among minoritized racial and ethnic groups.
View Article and Find Full Text PDFAm J Pathol
January 2025
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Alzheimer's disease (AD) is the most common type of dementia and one of the leading causes of death in elderly patients. The number of patients with AD in the United States is projected to double by 2060. Thus, understanding modifiable risk factors for AD is an urgent public health priority.
View Article and Find Full Text PDFJ Immunol Methods
January 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:
Complement functional assays are essential first-tier tests for a gamut of disorders spanning from inborn errors of the immune system which lead to recurrent severe infections, to angioedema attacks, presentation of autoimmune disease, thrombotic microangiopathies and rare kidney disorders. These assays evaluate the activity of the three complement pathways and specific complement components, which helps in differential diagnosis and monitoring disease progression. The rising use of complement inhibitors for treating complement-mediated thrombotic microangiopathies has heightened the demand for personalized treatment plans and laboratory assessment of complement blockage.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
January 2025
Maimonides Medical Center, Department of Orthopaedic Surgery and Rehabilitation, Brooklyn, NY, USA.
Introduction: The humeral head is the second most common site for osteonecrosis but its epidemiology is poorly described. This study aimed to better understand its treatment in the United States by 1) evaluating total operative procedures with rates normalized to the annual surgical volume; 2) determining trends of non-joint preserving (shoulder arthroplasty) vs. joint preserving procedures; and 3) quantifying rates of operative techniques in different aged cohorts (<50 vs.
View Article and Find Full Text PDFJ Subst Use Addict Treat
January 2025
Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, 1070 Arastradero Road, Palo Alto, CA 94304, United States of America. Electronic address:
Background: Opioid-related overdoses increased substantially during the COVID-19 pandemic, eliciting an urgent demand for accessible treatment for individuals with opioid use disorder (OUD) and those who support them (support persons). Support persons can improve treatment initiation and retention in their individuals with OUD. Additionally, support persons may have their own mental health needs related to their loved one's OUD.
View Article and Find Full Text PDFBioorg Med Chem Lett
January 2025
Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, La Jolla, CA 92037, United States. Electronic address:
Screening of the ChemDiv molecular library in cholesterol media against Mycobacterium tuberculosis (Mtb) H37Rv strain identified a novel isoxazole thiophene hit as a putative Rv1625c/Cya activator with a promising in vitro activity and good pharmacokinetic properties. Twenty-nine analogs were synthesized to assess the structure-activity relationships (SAR) to further improve potency. The most notable analog was P15, which showed an intramacrophage EC = 1.
View Article and Find Full Text PDFPurpose: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have risen exponentially in usage and have been shown to exert neuroprotective and anti-inflammatory effects across multiple organ systems. This study investigates whether GLP-1RAs influence the risk for age-related ocular diseases.
Design: Retrospective cohort study.
Am Heart J
January 2025
Division of Cardiology, Geffen School of Medicine at University of California, Los Angeles, California, United States. Electronic address:
Magn Reson Imaging
January 2025
Institute of Fluid Mechanics, University of Rostock, Rostock, Germany.
Purpose: To improve the current method for MRI turbulence quantification which is the intravoxel phase dispersion (IVPD) method. Turbulence is commonly characterized by the Reynolds stress tensor (RST) which describes the velocity covariance matrix. A major source for systematic errors in MRI is the sequence's sensitivity to the variance of the derivatives of velocity, such as the acceleration variance, which can lead to a substantial measurement bias.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
View Article and Find Full Text PDFMucosal Immunol
January 2025
Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10065, United States; Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, United States; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School, New York, NY 10065, United States. Electronic address:
Our immune system and gut microbiota are intricately coupled from birth, both going through maturation during early life and senescence during aging almost in a synchronized fashion. The symbiotic relationship between the human host and microbiota is critically dependent on a healthy immune system to keep our microbiota in check; while the microbiota provides essential functions to promote the development and fitness of our immune system. The partnership between our immune system and microbiota is particularly important during early life, in which microbial ligands and metabolites shape the development of the immune cells and immune tolerance; during aging, having sufficient beneficial gut bacteria is critical for the maintenance of intact mucosal barriers, immune metabolic fitness, and strong immunity against pathogens.
View Article and Find Full Text PDFJ Stomatol Oral Maxillofac Surg
January 2025
Department of Pathology, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address:
Background: This review aimed to emphasize the implications of DNA content in head and neck squamous cell carcinoma (HNSCC), focusing on its predictive value, role in patient stratification, and potential as a therapeutic target for this malignancy.
Methods: A narrative review of the literature was conducted through electronic database searches.
Results: In conventional HNSCC, aneuploid tumors are associated with increased lymph node metastasis, locoregional recurrences, poor response to radiotherapy and chemotherapy, and worse prognosis.
Environ Pollut
January 2025
Department of Civil Engineering, Khulna University of Engineering & Technology, Khulna, 9203, Bangladesh; Department of Civil Engineering, University of Creative Technology Chittagong, Chattogram, 4212, Bangladesh.
Criteria air pollutant exposure impacts human health through various pathways. Preterm birth (PTB) is one of the major adverse birth outcomes (ABO) associated with such exposure. Although numerous global and regional studies have been conducted on this issue, few have recently investigated the impact of major criteria air pollutant exposure on PTBs in Bangladesh, one of the world's most polluted countries with the highest relative PTB rate.
View Article and Find Full Text PDFAm J Transplant
January 2025
Department of Pediatrics, University of Wisconsin Madison, Madison, WI.
Hepatitis C virus (HCV) infection is increasing in prevalence due to the growing opioid epidemic; however, its impact on pediatric kidney transplantation is unknown. This study compared kidney transplant outcomes between HCV-positive and propensity-score-weighted HCV-negative pediatric recipients. It also examined HCV-positive kidney utilization for pediatric transplantation in the United States.
View Article and Find Full Text PDFBioelectrochemistry
January 2025
Graduate School of Engineering, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522 Japan.
Heparin concentration c in a blood extracorporeal circulation has been real-timely predicted based on the relaxation strength Δε at relaxation frequency f extracted by relaxation time distribution (RTD). The simulated extracorporeal circulation was conducted to optimize the number of Δε for the prediction of c using the porcine whole blood (WB) and low-leukocyte and -platelet blood (LLPB) under the condition of the gradual increment of c from 0 to 8 U/mL with constant flow rate and blood temperature. The experimental results show that among the three relaxation strengths Δε, Δε and Δε (in ascending order of frequency), Δε at f = 5.
View Article and Find Full Text PDFNurs Outlook
January 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Craig-Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA; Clinical Futures, Children's Hospital of Philadelphia, Philadelphia, PA.
Background: School nurses (SNs) can play important roles in the health of sexual and gender minority (SGM) youth, yet little is known about their knowledge and attitudes toward this population.
Purpose: To understand SNs' knowledge and attitudes in caring for SGM youth across the United States.
Methods: We designed and disseminated the School Nurses and LGBTQ Youth online survey in May 2023 to U.
J Surg Res
January 2025
Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
Introduction: In the United States, while most nonmalignant polyps are effectively treated through endoscopic removal, colectomy remains a treatment option for selected cases of nonmalignant polyps (NMPs) and colon cancer. This study aimed to compare postoperative outcomes for colectomies in these two conditions, hypothesizing similar complication rates.
Methods: We conducted a retrospective review of the American College of Surgeons National Surgical Quality Improvement Program database from 2015 to 2021, including patients who underwent elective colectomies for colon cancer or NMPs.
J Biomech
January 2025
The Joint Department of Biomedical Engineering, the University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; North Carolina State University, Raleigh, NC, United States.
Throughout childhood growth and development, both the nervous and the musculoskeletal systems undergo rapid change. The goal of this study was to examine the impact of growth-related changes in skeletal size and muscle strength on the neural control of finger force generation. By modifying an existing OpenSim hand model in accordance with pediatric anthropometric data, we created 10 distinct models representing males and females at each year of development from 6 to 10 years old.
View Article and Find Full Text PDFSurgery
January 2025
Department of Health Professions Education, MGH Institute for Health Professions Education, Boston, MA; Department of Surgery, Baylor Scott & White Health, Temple, TX. Electronic address: https://twitter.com/_baaw_.
Background: Gossip, defined by social scientists as "evaluative talk about an absent third party," is anecdotally pervasive yet poorly understood in surgical residency programs. Gossip is known to have both positive and negative impacts. This study sought to deconstruct the role of gossip in surgical residency and evaluate its impact through the lens of surgical residents.
View Article and Find Full Text PDFMar Pollut Bull
January 2025
Virginia Institute of Marine Science, William & Mary, Gloucester Point, VA 23062, United States of America.
This study assessed effectiveness of regulations reducing environmental butyltin concentrations in Southern Chesapeake Bay over the 1999-2021 period. Water column monitoring of the Elizabeth River from 1999 to 2006 demonstrated decreasing TBT from 2003 to 2006 (average >1 ng/L at most stations) to <1 ng L by 2019 but with higher concentrations of degradation products DBT and MBT. TBT degrades to DBT and MBT within sediments, and releases degradation products over time.
View Article and Find Full Text PDFClin Imaging
January 2025
NYU Langone Health, Department of Radiology, 660 1st Ave, New York, NY 10016, United States.
Purpose: Though prior studies have proven CTC's efficacy in outpatients, its utility in the inpatient setting has not been studied. We evaluated the efficacy of a modified CTC protocol in the inpatient setting, primarily for patients awaiting organ transplantation.
Methods: This retrospective study compared a group of inpatient CTCs from 2019 to 2021 and a randomly selected, age-matched 2:1 control group of outpatient CTCs.
Clin Imaging
January 2025
Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Purpose: To perform a nationwide analysis of ablation compared to partial and total nephrectomy for the management of renal cell carcinoma (RCC) to evaluate utilization trends and disparities in the USA.
Materials And Methods: The 2016-2020 National Inpatient Sample was analyzed. Using ICD-10, we identified the diagnosis of RCC then analyzed the utilization trends of ablation and nephrectomies (both partial and complete).
Stud Hist Philos Sci
January 2025
Philosophy Department, Tufts University, United States of America; Black Hole Initiative, Harvard University, United States of America; Lichtenberg Group for History and Philosophy of Physics, University of Bonn, Germany. Electronic address:
In this paper, I provide an account of direct (vs. indirect) detection in gravitational-wave astrophysics. In doing so, I highlight the epistemic considerations that lurk behind existing debates over the application of the term "direct".
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