Evaluating Resonant Acoustic Mixing as a Wet Granulation Process.

Control of powder properties is crucial for industrial processes across the food, pharmaceutical, agriculture, and mineral processing industries, and granulation is an important tool for providing agglomerated particles with controllable properties. However, existing granulation processes are not readily integrated with other processing steps and are not appropriate for some types of materials. Adding resonant acoustic-based granulation to the toolkit has the potential to widen the achievable parameter space and, importantly, integrate granulation into chemistry and blending operations that are already being performed on the RAM platform, resulting in process intensification.

The mental health care system for children and adolescents in Greece: a review and structure assessment.

Background: The mental health system in Greece faces challenges to complete its transition to a community-oriented model, having significant concerns for child and adolescent care due to lower coverage and service gaps. This component of the mental health system has not been comprehensively evaluated.

Methods: We conducted a review of the mental health care system for children and adolescents in Greece.

Birthing parent perspectives on measuring the quality of perinatal care: metrics, timing, and process.

Objective: Centering birthing parents is critical for improving reproductive health policies and practices. This study investigates patient perspectives on measuring the quality of perinatal care.

Methods: A cross-sectional qualitative research study was conducted at an academic medical center in the Southeastern United States.

Breast Adenocarcinoma and Cold Agglutinin Disease: A Paraneoplastic Syndrome.

Autoimmune hemolytic anemia is a disorder that is characterized by the destruction of red blood cells through an autoimmune process, such as temperature-dependent antibodies. The two predominant types, cold agglutinin and warm agglutinin disease, typically possess different underlying etiologies. Prompt recognition and workup of autoimmune hemolytic anemia should be prioritized to potentially uncover any underlying primary cause, such as malignancy.

A Citation Analysis of the Top 50 Most Cited Nurse Practitioner Publications.

The role of nurse practitioners (NPs) has become integral to healthcare systems worldwide. Originating in the United States over 50 years ago, it has since been adopted by countries such as Canada, the United Kingdom, and Australia. To honor the research and contributions that have shaped the NP discipline, it is valuable to review and recognize key literature that has significantly impacted its development.

Radiographic Evaluation of the Prevalence of External Root Resorption in Patients With Periodontitis in Indore: A Cross-Sectional Study.

Objective Permanent teeth roots undergo resorption under pathologic conditions such as trauma, orthodontic treatment, pulpal infections, periodontitis, and periodontal therapy. The present study aimed to determine the prevalence of external root resorption (ERR) in patients with periodontitis as seen in orthopantomography (OPGs). Methodology This single-center, retrospective, cross-sectional radiographic study was conducted from January 2021 to December 2022, including 656 orthopantomographs (OPGs) from patients with periodontitis.

The Surgical Repair of an Avulsion Dog Bite and Scar Revision in Highly Melanated Skin: A Case Report.

Dog bites are one of the most common injuries in the United States, with varying presentations such as avulsion injuries and lacerations, and they range from a single bite to multiple bites in a victim. The severity of the dog bite is often the biggest factor in determining the treatment course. This report discusses the treatment of a 60-year-old male with severe facial avulsion trauma from a dog bite.

Use of fluoroquinolones and risk of rhegmatogenous retinal detachment: a retrospective cohort study using two nationwide representative claims databases.

Background: Although biological plausibility suggests that fluoroquinolones could lead to rhegmatogenous retinal detachment (RRD) through collagen degradation, real-world evidence on their relative risk of RRD is inconsistent, with limited information on absolute risk estimates.

Objective: The study aimed to estimate the RRD risk associated with fluoroquinolones versus other antibiotics with similar indications (i.e.

Bibliometric analysis of nanotechnology in spinal cord injury: current status and emerging frontiers.

Objective: The objective of this study was to analyze the impact of nanotechnology on the treatment and recovery of spinal cord injury (SCI), a condition that has profound global effects on physical and psychological health.

Methods: We utilized the Web of Science Core Collection to obtain bibliometric data. With the tools such as VOSviewer and CiteSpace, we conducted a comprehensive review of 422 relevant publications to identify research trends and influential works in the field of nanotechnology applied to SCI.

A real-world pharmacovigilance study of neuroleptic malignant syndrome based on FDA adverse event reporting system.

Background: Neuroleptic malignant syndrome (NMS) is a rare but potentially life-threatening adverse drug reaction. This study aims to identify the most prevalent drugs associated with the risk of NMS according to the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database.

Methods: Analyses were performed using data from the FAERS database from January 2004 to June 2024.

is essential for zebrafish embryogenesis and pronephros formation.

Background And Objectives: Friedreich's Ataxia (FRDA) is a genetic disease that affects a variety of different tissues. The disease is caused by a mutation in the gene ( which is important for the synthesis of iron-sulfur clusters. The primary pathologies of FRDA are loss of motor control and cardiomyopathy.

Freshness in Salmon by Hand-Held Devices: Methods in Feature Selection and Data Fusion for Spectroscopy.

Salmon fillet was analyzed via hand-held optical devices: fluorescence (@340 nm) and absorption spectroscopy across the visible and near-infrared (NIR) range (400-1900 nm). Spectroscopic measurements were benchmarked with nucleotide assays and potentiometry in an exploratory set of experiments over 11 days, with changes to spectral profiles noted. A second enlarged spectroscopic data set, over a 17 day period, was then acquired, and fillet freshness was classified ±1 day via four machine learning (ML) algorithms: linear discriminant analysis, Gaussian naïve, weighted -nearest neighbors, and an ensemble bagged tree method.

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells.

Background: The insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic treatment of TED inhibits activation of the IGF-1R/TSH-R complex.

Learning dynamic cognitive map with autonomous navigation.

Inspired by animal navigation strategies, we introduce a novel computational model to navigate and map a space rooted in biologically inspired principles. Animals exhibit extraordinary navigation prowess, harnessing memory, imagination, and strategic decision-making to traverse complex and aliased environments adeptly. Our model aims to replicate these capabilities by incorporating a dynamically expanding cognitive map over predicted poses within an active inference framework, enhancing our agent's generative model plasticity to novelty and environmental changes.

Dietary caffeine and its negative link to serum Klotho concentrations: evidence from the National Health and Nutrition Examination Survey.

Background: This is the initial investigation assessing the association between caffeine consumption through diet and circulating Klotho concentrations, with Klotho being recognized as a key biomarker of healthspan and aging.

Methods: This cross-sectional analysis utilized data from 11,169 adults who participated in the National Health and Nutrition Examination Survey (NHANES). Caffeine consumption was evaluated using 24-h dietary recall interviews by trained professionals, and serum Klotho concentrations were measured via an enzyme-linked immunosorbent assay (ELISA).

Evidence of compensatory neural hyperactivity in a subgroup of breast cancer survivors treated with chemotherapy and its association with brain aging.

Introduction: Chemotherapy-related cognitive impairment (CRCI) remains poorly understood in terms of the mechanisms of cognitive decline. Neural hyperactivity has been reported on average in cancer survivors, but it is unclear which patients demonstrate this neurophenotype, limiting precision medicine in this population.

Methods: We evaluated a retrospective sample of 80 breast cancer survivors and 80 non-cancer controls, aged 35-73, for which we had previously identified and validated three data-driven, biological subgroups (biotypes) of CRCI.

Proteomic analysis of the subsp. SS14 strain: coverage and comparison with the Nichols strain proteome.

Introduction: Strains of the syphilis spirochete, ssp. , group into one of two deep-branching clades: the Nichols clade or the globally dominant Street Strain 14 (SS14) clade. To date, in-depth proteome-wide analyses have focused on Nichols clade strains.

Genomic analysis of isolated from surface water and animal sources in Chile reveals new T6SS effector protein candidates.

Type VI Secretion Systems (T6SS), widely distributed in Gram-negative bacteria, contribute to interbacterial competition and pathogenesis through the translocation of effector proteins to target cells. harbor 5 pathogenicity islands encoding T6SS (SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22), in which a limited number of effector proteins have been identified. Previous analyses by our group focused on the identification of candidate T6SS effectors and cognate immunity proteins in genomes deposited in public databases.

Porcine peritoneal macrophages are susceptible to porcine reproductive and respiratory syndrome virus infection.

Previous studies have suggested that porcine peritoneal macrophages (PPMs) are resistant to PRRSV infection, whereas porcine alveolar macrophages (PAMs) are highly susceptible. This contrast is intriguing, as both cell types belong to the same monocyte/macrophage family. The current study aimed to investigate the host factors contributing to the differing susceptibility of PPMs and PAMs to PRRSV infection.

Bactericidal efficacy of low dose gaseous ozone against clinically relevant multidrug-resistant bacteria.

Introduction: Healthcare-associated infections (HAIs) pose a significant challenge in acute care hospitals, particularly in intensive care units, due to persistent environmental contamination despite existing disinfection protocols and manual cleaning methods. Current disinfection methods are labor-intensive and often ineffective against multidrug-resistant (MDR) pathogens, highlighting the need for new, automated, hands-free approaches.

Methods: This study evaluates the bactericidal efficacy of low concentrations of gaseous ozone (5 ppm) against clinically relevant and often MDR bacteria under various concentrations, contact times, temperatures, and environmental conditions.

Socioeconomic and spatial distribution of depressive symptoms and access to treatment in Peru: A repeated nationwide cross-sectional study from 2014 to 2021.

Background: Globally, evidence indicates that poverty and geographical setting influence the prevalence of depressive symptoms and access to treatment. Therefore, this study aimed to evaluate the socioeconomic and spatial distribution of depressive symptoms and treatment in Peru.

Methods: We conducted an observational study based on the analysis of secondary data derived from the Peruvian Demographic and Health Surveys for 2014-2021.

Health care providers' comfort caring for trauma-exposed patients in the primary care setting: A mixed methods approach.

Introduction: Patients seeking primary care often present with health concerns related to psychological trauma, highlighting the importance of health care providers' (HCPs) comfort discussing trauma in the primary care setting. This study used mixed methods, including qualitative content analysis, to (1) document HCPs' trauma-related comfort levels and factors contributing to discomfort and (2) examine the associations between provider-level factors and comfort.

Materials And Methods: Direct patient care providers (74.

Multidisciplinary interventions in ectodermal dysplasia: A clinical case report.

Ectodermal dysplasia (ED) is a spectrum of inherited disorders that compromise the development and function of ectodermal structures, like hair, nails, and teeth. This case report describes a 17-year-old male with sparse hair and cognitive difficulties who was diagnosed with ED in childhood. A multidisciplinary evaluation with dermatology, neurology, and dentistry revealed characteristic clinical features, and the histopathological diagnosis was confirmed via punch biopsy.

Telemedicine: Future of the healthcare system and its impact on patient satisfaction: A literature review.

Background And Objectives: The utilization of telemedicine has increased dramatically since the onset of the COVID-19 pandemic. In this review, we examined studies published within the past five years that investigated the impact of telemedicine on patient satisfaction.

Methods: Four investigators utilized PubMed and Google Scholar to find studies published within the past five years that assessed patient satisfaction with telemedicine in the field of adult primary care, using either the Press Ganey or CAHPS surveys.

Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition.

[This corrects the article DOI: 10.3389/fmolb.2021.