Enhancing the psychological well-being and sleep quality of healthcare providers with a multimodal psychological support program: a randomized controlled trial.

Background: The COVID-19 pandemic significantly challenged the global healthcare system, especially frontline healthcare professionals, such as those working in intensive care units (ICUs). In late 2022, a sudden increase in COVID-19 cases in China led to a large number of ICU admissions, requiring new ICU staff (non-ICU professionals to work in ICUs), exacerbating their stress. This study aimed to develop an effective stress management strategy for new ICU professionals, focusing on reducing the detrimental effects of stress on their psychological state.

"You find yourself in a very humiliating situation": experiences of people living with post-tuberculosis lung disease in Brazil.

Background: Brazil remains one of the 30 countries with the highest tuberculosis (TB) and TB-HIV coinfection burden. Post-TB lung disease (PTLD) is a set of sequelae that can occur in people who have been cured of TB.

Aim: To learn about the experiences of people living with PTLD (PLPTLD) and how healthcare workers (HCW) manage PTLD.

Enhancing Cure Rate Analysis Through Integration of Machine Learning Models: A Comparative Study.

Cure rate models have been thoroughly investigated across various domains, encompassing medicine, reliability, and finance. The merging of machine learning (ML) with cure models is emerging as a promising strategy to improve predictive accuracy and gain profound insights into the underlying mechanisms influencing the probability of cure. The current body of literature has explored the benefits of incorporating a single ML algorithm with cure models.

Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado.

Background: High prices and other access barriers have contributed to the rise of a market for compounded glucagon-like peptide-1 receptor agonists for weight loss in the United States. This market has not been systematically studied. We conducted a pilot study to assess the prevalence, characteristics, and advertising content of direct-to-consumer providers of compounded glucagon-like peptide-1 products for weight loss in Colorado.

Mental Health Care Works: Insights From a Public Service Campaign.

The United States is experiencing a mental health crisis, with COVID-19 increasing the prevalence of mental health concerns and demand for services, but also leaving millions without care, including many who do not know that treatment is needed or available. The American Psychiatric Association Foundation's Mental Health Care Works campaign was informed by results from an assessment of mental health awareness and perceptions of adults in the United States. These results highlighted the need for more public education about the efficacy of mental health care and ongoing need to normalize treatment and make care more accessible and relatable.

"Love, Your Mind": The Pioneering Mental Health Initiative From Huntsman Mental Health Institute and the Ad Council.

Mental health experts recognize that comprehensive communications programs play a role in addressing the mental health crisis in the United States. In order to reframe discourses around mental health, reduce stigma, and increase prioritization of mental health, the Ad Council conducted extensive research that has fueled the development of "Love, Your Mind," a national communications campaign launched in October 2023 with founding support from Huntsman Mental Health Institute. This article focuses on insights derived from a large-scale audience segmentation study that identified six segments across total U.

Revolutionizing Diabetic Retinopathy Screening: Integrating AI-Based Retinal Imaging in Primary Care.

Diabetic retinopathy (DR) is a public health issue affecting millions in the United States and Europe. However, despite strong recommendations for screening at regular intervals by many professional societies, including the American Diabetes Association and the American Academy of Ophthalmology, screening rates remain suboptimal, with only 50-70% of patients with diabetes adhering to recommended annual eye exams. Barriers to screening include lack of awareness, socioeconomic factors, health care system fragmentation, and workforce shortages, among others.

Developing an Annual Review of the Literature.

Many national meetings and speaker series feature an "Annual Review of the Literature" (ARL) session in which an individual or team presents a sampling of articles, selected and prepared because they represent important current topics or new ideas in the discipline of interest. Despite this, there is little in the medical literature describing how to thoughtfully and systematically develop these sessions. We identify best practices that we have developed and used in the United States Clerkship Directors of Internal Medicine (CDIM) over many years.

Associations Between Socioeconomic, Spatial and Educational Factors and Midlife Periodontal Disease Risk: Evidence From 'High School and Beyond'.

Background: Periodontal disease (PD) is a prevalent, preventable and treatable oral infection associated with substantial morbidity globally. There is little information from population-representative cohort studies about the sociodemographic, educational and other early life factors that stratify PD risk.

Methods: We used data from the U.

Prevalence of Depression in Older Adults and the Potential Protective Role of Volunteering: Findings From the LongROAD Study.

Background: As the US population continues to age, depression and other mental health issues have become a significant challenge for healthy aging. Few studies, however, have examined the prevalence of depression in community-dwelling older adults in the United States.

Methods: Baseline data from the Longitudinal Research on Aging Drivers study were analyzed to examine the prevalence and correlates of depression in a multisite sample of community-dwelling adults aged 65-79 years who were enrolled and assessed between July 2015 and March 2017.

Infant mental health integration into OB care leads to increased connection to services during the perinatal period.

We compared referrals and connection to care between perinatal patients: 90 receiving OB/GYN care in clinics with integrated behavioral health consultants with infant mental health specialization (IMH-BHC), and 68 receiving traditional care, in the United States. Participants identified as: Native American/Alaskan native, 1.90%; Asian, .

A nomograph model for predicting the risk of diabetes nephropathy.

Objective: Using machine learning to construct a prediction model for the risk of diabetes kidney disease (DKD) in the American diabetes population and evaluate its effect.

Methods: First, a dataset of five cycles from 2009 to 2018 was obtained from the National Health and Nutrition Examination Survey (NHANES) database, weighted and then standardized (with the study population in the United States), and the data were processed and randomly grouped using R software. Next, variable selection for DKD patients was conducted using Lasso regression, two-way stepwise iterative regression, and random forest methods.

Oral health articles in primary care journals: A bibliometric review.

Objectives: Primary care lacks emphasis on oral health (OH) despite its major effects on one's overall health. This mixed-methods bibliometric study was conducted to assess the content of OH in primary care journals.

Methods: Sixty-seven of the most influential journals were identified from primary care specialties and disciplines using Scopus CiteScore metrics and expert opinion.

Capturing human response to Winter Storm Frankie based on X (formerly known as Twitter) data.

This study delves into how people responded to Winter Storm Frankie in the United States based on X (formerly known as Twitter®) data according to a multitude of regions, periods, sociodemographic characteristics, census regions, and geographical scales. This study finds that people actively respond to natural disasters on X during the winter storm week. Specifically, the highest number of keywords during the winter storm week is 1.

Tornado sheltering: Challenges and solutions including public storm shelters.

Tornadoes are a considerable threat across the United States, occurring in many regions of the country on a frequent basis throughout the year. Finding a safe place to go during a tornado can be a challenge for many individuals, and, in some situations, there is no safe place available. Increasing the number of tornado shelters and establishing them in regions where they are not currently present can greatly improve the safety of local residents and visitors, especially for those who are unable to afford retrofitting a shelter into their own home or business.

Stathmin 1 expression in neuroendocrine and proliferating prostate cancer.

Prostate cancer (PCa) is the second leading cause of cancer-related mortality among men in the United States. While PCa initially responds to androgen deprivation therapy, a significant portion progresses to castration-resistant PCa. Approximately 20-25% of these cases acquire aggressive neuroendocrine (NE) features, ultimately leading to neuroendocrine prostate cancer (NEPC).

Bayesian item response theory to estimate power in clinical trials with patient-reported outcomes as endpoints.

Purpose: Patient-Reported Outcomes (PROs) are widely used in clinical trials, epidemiological research, quality of life (QOL) studies, routine clinical care, and medical surveillance. The Patient Reported Outcomes Measurement Information System (PROMIS) is a system of reliable and standardized measures of PROs developed with Item Response Theory (IRT) using latent scores. Power estimation is critical to clinical trials and research designs.

"We Need Gentleness": Isolation, Loneliness, and Implications for Psychosocial Counseling Among People with HIV who are on Methadone Maintenance Treatment and Experience Common Mental Disorders in Vietnam.

The psychological experiences and needs of people with human immunodeficiency virus (HIV) who use methadone maintenance treatment and have common mental disorders in Hanoi, Vietnam remain unknown. Due to limited services for common mental disorders, optimal delivery methods for psychotherapy are also unknown. Accordingly, this qualitive study explored both symptoms of common mental disorders among this population and the preferred qualifications and characteristics of a mental health counselor.

Associations between parent and adolescent weight outcomes within two parent approaches to family-based adolescent obesity treatment: Secondary analyses from the TEENS+ pilot trial.

Objective: To examine associations between parent and adolescent weight change within two parent approaches to adolescent obesity treatment.

Methods: Adolescent (M = 13.7 ± 1.

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells.

Adeno-associated virus (AAV) vectors are a leading platform for gene therapy. Recently, AAV-mediated gene therapy in the inner ear has progressed from laboratory use to clinical trials, but the lower transduction rates in outer hair cells (OHCs) in the organ of Corti and in vestibular hair cells in adult mice still pose a challenge. OHCs are particularly vulnerable to inner ear insults.

Caregiving responsibility and psychological distress among community-dwelling cancer survivors in the United States.

Purpose: There are over 18 million cancer survivors in the U.S., with a projected increase of 24.

The etiology and prevention of early-stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques.

Aging rhesus macaques provide a unique model for learning how age and inflammation drive early-stage pathology in sporadic Alzheimer's disease, and for testing potential therapeutics. Unlike mice, aging macaques have extensive association cortices and inflammatory signaling similar to humans, are apolipoprotein E ε4 homozygotes, and naturally develop tau and amyloid pathology with marked cognitive deficits. Importantly, monkeys provide the unique opportunity to study early-stage, soluble hyperphosphorylated tau (p-tau), including p-tau217.

Accessing Azetidines through Magnesium-Mediated Nitrogen Group Transfer from Iminoiodinane to Donor-Acceptor Cyclopropanes.

Herein, we report a Lewis acid-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. This protocol operates under mild, transition-metal-free conditions, and showcases excellent chemoselectivity, along with broad functional group tolerance. We report for the first time that challenging alkyl donor-acceptor cyclopropanes can undergo ring expansion leading to aliphatic azetidines without relying on external oxidants or precious transition-metal catalysts.

Diacylation of Peptides Enables the Construction of Functional Vesicles for Drug-Carrying Liposomes.

Membrane-forming phospholipids are generated in cells by enzymatic diacylation of non-amphiphilic polar head groups. Analogous non-enzymatic processes may have been relevant at the origin of life and could have practical utility in membrane synthesis. However, aqueous head group diacylation is challenging in the absence of enzymes.