Pharmaceutical Education in LGBTQIA+ Healthcare: A Scoping Review of Educational Strategies and Barriers.

Objective: To map and describe training and educational strategies and identify barriers faced in pharmaceutical education on LGBTQIA+ healthcare.

Methods: A comprehensive search was performed in PubMed, Scopus, LILACS, and Google Scholar until December 2023. Publications evaluating pharmaceutical education for students or pharmacists on LGBTQIA+ health topics were included.

Multivitamin Use and Mammographic Breast Density.

Purpose: The association of multivitamin use with mammographic breast density (MBD) is unclear, with two studies reporting conflicting findings. We, therefore, investigated the associations of multivitamin use with volumetric measures of MBD; volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV) in a diverse population of women.

Methods: This cross-sectional study included 1,083 women recruited during their annual screening mammograms at the Joanne Knight Breast Health Center, Washington University School of Medicine, St.

Exploring Biomarkers of Systemic Oxidative Stress and Placental Insufficiency in Pregnant Women with Inflammatory Bowel Diseases.

Background: Inflammatory bowel disease (IBD) often presents during the fertile age and may affect pregnancy outcomes. Both IBD and selected pregnancy complications involve oxidative stress. Soluble FMS-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) serve as biomarkers of placental insufficiency, while free thiols (FT) reflect systemic oxidative stress.

A pilot study on traditional vs. digital self-administered questionnaire completion in the International Weight Control Registry.

Background & Aim: Scarce reports on the characteristics of individuals choosing to enroll in obesity-related registries via digital or traditional methods exist. We examined whether characteristics of participants who enrolled in the International Weight Control Registry (IWCR) via digital surveys differed from those who enrolled with paper surveys.

Methods: This manuscript describes the pilot phase of IWCR recruitment of eligible participants from one collaborating country.

Trends in Shoulder Arthroplasty Across a Large Health System Over the Past 10 Years.

Background: The indications and techniques for shoulder arthroplasty (SA) have significantly expanded since the introduction of reverse shoulder arthroplasty (rTSA) in 1991. While national databases provide broad trends, they often lack the granularity needed for patient-specific insights. This study aims to analyze trends in anatomic total shoulder arthroplasty (aTSA), rTSA, and hemiarthroplasty (HA) within a large multihospital system over the past decade.

Eating disorder symptoms and profiles of emotion regulation strategy use.

Background: Emotion regulation difficulties are widely thought to be a transdiagnostic risk factor for eating disorders. However, there is limited data on the precise patterns of emotion regulation strategy use that characterize eating-disorder symptoms. Our aim was to comprehensively examine the relationship between emotion-regulation strategy use and eating-disorder symptoms, identifying profiles of strategy use that might characterize these symptoms.

Blood-brain barrier crossing biopolymer activates immunity in primary brain lymphoma by targeting c-Myc and α-PD-1: Artificial intelligence analysis.

Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor response to pharmacological treatment, partially due to insufficient drug delivery across blood-brain barrier. In this study, we developed a novel therapy for this lymphoma by combining a targeted nanopolymer treatment with an immune checkpoint inhibitor antibody (anti-PD-1). A N-(2-hydroxypropyl)methacrylamide copolymer-based nanoconjugate was designed to block tumor cell c-Myc oncogene expression by antisense oligonucleotide.

Metabolite Fingerprinting by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.

The adoption of mass spectrometry for high-throughput screening in drug discovery has become increasingly prevalent and has enabled label-free screening against diverse targets. Cellular assays for phenotypic screening, however, are primarily conducted by microscopy as there remain many challenges associated with conducting phenotypic screens via ultra-high throughput mass spectrometry. Following a simple on-plate extraction, infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) was employed to directly sample the cell lysate at a speed of one sample per second with high mass resolution.

Reasons for donor heart offer refusal are often unrelated to the donor itself - when, why, and the "weekend effect".

Background: Most donor hearts offered for heart transplant (HT) in the United States (US) are turned down. We aimed to understand the reasons for this - focusing on those related to the potential recipient and HT center (i.e.

Enhancing pharmaceutical calculation proficiency: Exploring self-directed learning and self-reinforcement assessment strategies for student success.

Introduction: Proficiency in pharmaceutical calculations is essential for pharmacy students, particularly for their role in patient care. This study is to explore the impact of self-directed learning (SDL) and self-reinforcement assessment (SRA), (SDL/SRA), strategies on student performance in pharmaceutical calculations at [COP name].

Methods: The study was conducted from 2020 to 2022, which included first-year pharmacy students.

Experience using a state board of pharmacy adequate staffing form: A descriptive report.

Background: Between 30 and 50 % of all medication errors may be attributable to inadequate pharmacy staffing. Potentially understaffed pharmacies have garnered national media attention and fostered workforce crises. As such, Boards of Pharmacy (BOPs) have codified laws requiring pharmacists to document inadequate staffing events.

Providing integrated mental health care as a neurologist.

Mental health comorbidities are highly prevalent and problematic in epilepsy, making it important for neurologists to be equipped to manage their patients' mental health concerns. This article explores the paradigm shift toward integrated mental health care approaches, aiming to educate early-career neurologists on their role within epilepsy care. We focus on depression and anxiety, how they present in epilepsy, and the role of integrated mental health care in managing these comorbidities.

AI-driven report-generation tools in mental healthcare: A review of commercial tools.

Artificial intelligence (AI) systems are increasingly being integrated in clinical care, including for AI-powered note-writing. We aimed to develop and apply a scale for assessing mental health electronic health records (EHRs) that use large language models (LLMs) for note-writing, focusing on their features, security, and ethics. The assessment involved analyzing product information and directly querying vendors about their systems.

Ultrasound accuracy in acute diverticulitis: A systematic review and Meta-analysis.

Objectives: The utility of ultrasound for diagnosing diverticulitis, especially in high-risk cases with complicated diverticulitis, remains debated. This study aimed to provide contemporary quantitative data synthesis of the diagnostic accuracy of ultrasound in patients with suspected diverticulitis.

Methods: Scopus, PubMed, Google Scholar, and CENTRAL were searched from January 1st,1990 to September 15th, 2023, for potentially relevant articles.

Imaging trends and surgical outcomes for nephrolithiasis in the pediatric emergency department.

Objectives: There has been a marked rise in the incidence of pediatric nephrolithiasis over the past two decades. Although computed tomography (CT) is the gold standard for the diagnosis of nephrolithiasis, efforts to reduce minimize childhood exposure to ionizing radiation remain important. This study aims to assess current imaging trends and rates of surgical intervention for nephrolithiasis at the hospital level.

Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway.

This study investigated a series of novel cyclohexanecarboxamide derivatives 4a-e, 5a-e and 6a-e as anticonvulsant and neuroprotective agents. Compounds 4a-e, 5a-e, and 6a-e were synthesized starting from cyclohexanone and aniline derivatives and evaluated for their anticonvulsant effects using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models. The most potent compounds 4b, 5c, and 6d demonstrated 83.

Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state.

During muscle relaxation at low sarcoplasmic Ca-concentration, the 40-nm long tropomyosin coiled coil is attracted by the C-terminal regulatory domain of troponin subunit-I to a "steric-blocking" B-state position on actin subunits of cardiac and skeletal muscle thin filaments. Tropomyosin located in this B-state position obstructs myosin-binding sites on actin, limiting access of myosin-crossbridge heads on actin. In turn, the steric-hindrance imposed on myosin-binding diminishes actomyosin ATPase, crossbridge movement along actin, and contractility, thus causing relaxation.

Comparative analysis of the therapeutic effects of pregabalin, gabapentin, and duloxetine in diabetic peripheral neuropathy: A retrospective study.

Introduction: This study aimed to compare the effects of pregabalin, gabapentin, and duloxetine on diabetic peripheral neuropathy (DPN) to guide tailored treatment.

Materials And Methods: In this retrospective study, 180 patients with type 2 diabetes and DPN were matched 1:1:1 across three groups based on HbA1c and age, resulting in 60 patients per group. Clinical data were collected, and the painDETECT score was used to evaluate treatment response over six weeks.

Negative emotion differentiation, but not gastric interoception, is linked to "feeling fat" among women with elevated eating pathology.

"Feeling fat" is the subjective sensation of being overweight, which is not fully explained by one's body weight. Disruptions in emotion differentiation and gastric interoception may contribute to feeling fat. We hypothesized that poor negative emotion differentiation and poor gastric interoceptive accuracy would each be associated with higher levels of feeling fat after adjusting for negative affect intensity and body fat percentage.