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What have we learned from animal studies of immune responses to respiratory syncytial virus infection?
J Clin Virol
December 2024
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Article Synopsis
- Respiratory syncytial virus (RSV) commonly causes severe respiratory infections, especially in infants and vulnerable populations, and predicting its clinical course can be challenging as many severe cases occur in healthy individuals.
- Recent advancements in RSV vaccines and monoclonal antibodies make it crucial to identify high-risk people who would benefit from preventive treatments.
- Research using animal models has revealed complex immune responses to RSV, suggesting that specific immune system components and genetic markers may help in predicting disease severity and identifying at-risk patients for future studies.