3 results match your criteria: "United Kingdom and The Institute of Cancer Research[Affiliation]"
Prognostic and predictive impact of sex in locally advanced microsatellite instability high gastric or gastroesophageal junction cancer: An individual patient data pooled analysis of randomized clinical trials.
Eur J Cancer
May 2024
Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:
Article Synopsis
- Surgery combined with chemotherapy is the standard treatment for locally advanced gastric cancer (GC) and gastroesophageal junction cancer (GEJC), but outcomes are often poor, especially in specific genetic subtypes like dMMR/MSI-high.* -
- Analysis from several clinical trials shows that patients with MSI-high tumors generally have better survival rates than those with MSS/MSI-low tumors, and that female patients with MSS/MSI-low tumors tend to live longer than their male counterparts.* -
- The study emphasizes that sex can influence the effectiveness of treatments for both MSI-high and MSS/MSI-low non-metastatic GC/GEJC, with surprisingly higher chemotherapy risks noted in females with MSI-high cancers.*
Prostate cancer image guided radiotherapy: Why the commotion over rectal volume and motion?
Clin Transl Radiat Oncol
November 2023
The Royal Marsden NHS Foundation Trust, United Kingdom and The Institute of Cancer Research, United Kingdom.
Introduction: Distended rectums on pre-radiotherapy scans are historically associated with poorer outcomes in patients treated with two-dimensional IGRT. Subsequently, strict rectal tolerances and preparation regimes were implemented. Contemporary IGRT, daily online registration to the prostate, corrects interfraction motion but intrafraction motion remains.
View Article and Find Full Text PDFGI factors, potential to predict prostate motion during radiotherapy; a scoping review.
Clin Transl Radiat Oncol
May 2023
The Royal Marsden NHS Foundation Trust, United Kingdom and The Institute of Cancer Research, United Kingdom.
Purpose: A scoping literature review was conducted to identify gastrointestinal (GI) factors most likely to influence prostate motion during radiotherapy. We proffer that patient specific measurement of these GI factors could predict motion uncertainty during radiotherapy, facilitating personalised care by optimising treatment technique e.g.
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