Coupling tree-ring and geomorphic analyses to reconstruct the 1950s massive Glacier Lake Outburst Flood at Grosse Glacier, Chilean Patagonia.

Over recent decades, global warming has led to sustained glacier mass reduction and the formation of glacier lakes dammed by potentially unstable moraines. When such dams break, devastating Glacial Lake Outburst Floods (GLOFs) can occur in high mountain environments with catastrophic effects on populations and infrastructure. To understand the occurrence of GLOFs in space and time, build frequency-magnitude relationships for disaster risk reduction or identify regional links between GLOF frequency and climate warming, comprehensive databases are critically needed.

Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation.

Right ventricular injury (RVI) in respiratory failure receiving veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with significant mortality. A scoping review is necessary to map the current literature and guide future research regarding the definition and management of RVI in patients receiving VV ECMO. We searched for relevant publications on RVI in patients receiving VV ECMO in Medline, EMBASE, and Web of Science.

Status of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.

Rationale: Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan.

Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute hospitals.

Methods: A multidisciplinary cross-sectional questionnaire was used to investigate sepsis care in hospitals.

In silico drug repurposing at the cytoplasmic surface of human aquaporin 1.

Aquaporin 1 (AQP1) is a key channel for water transport in peritoneal dialysis. Inhibition of AQP1 could therefore impair water transport during peritoneal dialysis. It is not known whether inhibition of AQP1 occurs unintentionally due to off-target interactions of administered medications.

Kinetic Oscillation Stimulation for the Preventive Treatment of Chronic Migraine: A Randomized, Double-Blind, Sham-Controlled Trial.

Background And Objectives: The Chordate System administers kinetic oscillation stimulation (K.O.S) into the nasal cavity thereby potentially modulating the activity of trigemino-autonomic reflex.

Polymorphisms, Homocysteine Elevation, and Ischemic Stroke Susceptibility in East Asian and European Populations.

Background And Objectives: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme that regulates folate and homocysteine metabolism. Genetic variation in has been implicated in cerebrovascular disease risk, although research in diverse populations is lacking. We thus aimed to investigate the effect of genetically predicted MTHFR activity on risk of ischemic stroke (IS) and its main subtypes using a multiancestry Mendelian randomization (MR) approach.

Targeted Next-Generation Sequencing of Cell-Free DNA to Detect -Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa.

Purpose: Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) affects children in sub-Saharan Africa, but diagnosis via tissue biopsy is challenging. We explored a liquid biopsy approach using targeted next-generation sequencing to detect the -immunoglobulin (-Ig) translocation and EBV DNA, assessing its potential for minimally invasive BL diagnosis.

Materials And Methods: The panel included targets for the characteristic -Ig translocation, mutations in intron 1 of , mutations in exon 2 of , and three EBV genes: EBV-encoded RNA (EBER)1, EBER2, and EBV nuclear antigen 2.

Anti-Apartheid at the periphery: a case study of grassroots activism in Dundee, 1967-1990.

The histories of the global anti-apartheid struggle, and particularly the British Anti-Apartheid Movement (AAM), have predominantly been examined through a transnational and national prism, creating an inaccurate impression of a highly centralized and homogeneous movement. We argue, however, that refining the analysis to focus on the local setting reveals a more complex and diverse movement, which has not been fully captured in the existing scholarship. Using Dundee as a case study, this article charts the emergence, character, and evolution of anti-apartheid sentiment and activity in this small, peripheral industrial Scottish city.

The urban geography of pop in sixties Britain.

The explosion of pop culture in Britain between the late 1950s and the late sixties is usually taken to have been an urban phenomenon. Pop was the 'sound of the city' in Britain as much as America. But what kind of 'urban' was involved-big city, small town, centre, suburb? What kind of geographical reach did pop have across the different parts of the United Kingdom in the 1960s? What was the significance of London in a cultural movement that was simultaneously national and international? Understanding where pop was made and performed in its formative years helps explain why it took off so spectacularly in sixties Britain; it illuminates why post-war Britain was so receptive to and generative of pop music as well as the music's nationwide appeal.

Anniversary fever? History and the culture of NHS celebration.

Delivered a day after Britain's National Health Service (NHS) reached its 75th year since its opening on the Appointed Day of 5 July 1948, the Pimlott Lecture for 2023 explored the culture of NHS anniversary-making. What can the marking of these anniversaries tell us about changing attitudes towards the service, and indeed, the British state? Here, examining evidence from the media, government archives, and Mass Observation, we argue that NHS anniversaries have long functioned as points of reflection but that their role as moments of national celebration and even communion has come to the fore only recently and culminated in the apparent 'anniversary fever' of 2018. We will explore the reasons behind the growing public fervour, what it can tell us, and the lessons offered by our work on this (still) best-loved of British institutions for historians working on highly politicized objects in 'fevered' times.

Impact of Left Ventricular Size on Outcomes Following HeartMate 3 Left Ventricular Assist Device Implantation: Analysis of the European Registry for Patients With Mechanical Circulatory Support (EUROMACS).

We investigated the association of preimplant left ventricular end-diastolic diameter (LVEDD) with outcomes after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. Patients from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) registry who underwent HM3 implantation from August 2014 to February 2023 (n = 834) were analyzed according to preoperative LVEDD: less than or equal to 65 (n = 251), 65-80 (n = 441), and greater than or equal to 80 mm (n = 142). The mean age was 54.

Risk of cancer and reoperation after ileorectal anastomosis and ileal pouch-anal anastomosis in familial adenomatous polyposis.

Objectives: To prevent colorectal cancer (CRC), most patients with familial adenomatous polyposis (FAP) undergo (procto)colectomy with ileorectal anastomosis (IRA) or ileal pouch-anal anastomosis (IPAA). After surgery, these patients remain at risk of developing cancer in the remnant rectum or rectal cuff/pouch. We aimed to compare the long-term risk of cancer following IRA or IPAA in FAP.

Selecting Initial Conditions for Trajectory-Based Nonadiabatic Simulations.

ConspectusPhotochemical reactions have always been the source of a great deal of mystery. While classified as a type of chemical reaction, no doubts are allowed that the general tenets of ground-state chemistry do not directly apply to photochemical reactions. For a typical chemical reaction, understanding the critical points of the ground-state potential (free) energy surface and embedding them in a thermodynamics framework is often enough to infer reaction yields or characteristic time scales.

A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis.

Filamentous plant pathogenic fungi pose significant threats to global food security, particularly through diseases like Fusarium Head Blight (FHB) and Septoria Tritici Blotch (STB) which affects cereals. With mounting challenges in fungal control and increasing restrictions on fungicide use due to environmental concerns, there is an urgent need for innovative control strategies. Here, we present a comprehensive analysis of the stage-specific infection process of Fusarium graminearum in wheat spikes by generating a dual weighted gene co-expression network (WGCN).

Using ESPEN data for evidence-based control of neglected tropical diseases in sub-Saharan Africa: A comprehensive model-based geostatistical analysis of soil-transmitted helminths.

Background: The Expanded Special Project for the Elimination of Neglected Tropical Diseases (ESPEN) was launched in 2019 by the World Health Organization and African nations to combat Neglected Tropical Diseases (NTDs), including Soil-transmitted helminths (STH), which still affect over 1.5 billion people globally. In this study, we present a comprehensive geostatistical analysis of publicly available STH survey data from ESPEN to delineate inter-country disparities in STH prevalence and its environmental drivers while highlighting the strengths and limitations that arise from the use of the ESPEN data.

Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers.

Quantification of intrahepatic covalently closed circular DNA (cccDNA) is a key for evaluating an elimination of hepatitis B virus (HBV) in infected patients. However, quantifying cccDNA requires invasive methods such as a liver biopsy, which makes it impractical to access the dynamics of cccDNA in patients. Although HBV RNA and HBV core-related antigens (HBcrAg) have been proposed as surrogate markers for evaluating cccDNA activity, they do not necessarily estimate the amount of cccDNA.

NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth.

Purpose: Advanced prostate cancer (PCa) is invariably fatal with the androgen receptor (AR) being a major therapeutic target. AR signaling inhibitors have improved overall survival for men with advanced PCa, but treatment resistance is inevitable and includes reactivation of AR signaling. Novel therapeutic approaches targeting these mechanisms to block tumor growth is an urgent unmet clinical need.

Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity.

Case-only designs in longitudinal cohorts are a valuable resource for identifying disease-relevant genes, pathways, and novel targets influencing disease progression. This is particularly relevant in Alzheimer's disease (AD), where longitudinal cohorts measure disease "progression," defined by rate of cognitive decline. Few of the identified drug targets for AD have been clinically tractable, and phenotypic heterogeneity is an obstacle to both clinical research and basic science.

Prevalence of mental health conditions in post-conflict Kasai Province, Democratic Republic of the Congo: A repeated, cross-sectional study.

Globally, one in five people in post-conflict areas are estimated to be living with a mental health condition. As a key public health issue, these conditions negatively affect individuals, communities, and societies to function after a conflict. Documenting the prevalence of mental health conditions amongst these populations is crucial to prioritise and guide future mental health interventions.

Exploring the perceptions of the effect of the COVID-19 pandemic on the mental well-being and medical education of medical students in Northern Ireland, in addition to the perceived barriers to seeking support; a qualitative study.

Introduction: The COVID-19 pandemic had a negative effect on population mental health. Medical students may have been particularly affected, whom prevalence of mental health conditions was already high before the pandemic hit, due to the difficult and stressful academic programme. In Northern Ireland specifically, mental well-being levels are the lowest across the UK; however limited research exists examining the medical student cohort.

Let-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B.

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of the target genes in the cell. Breast cancer is responsible for the majority of cancer-related deaths among women globally. It has been proven that deregulated miRNAs may play an essential role in the progression of breast cancer.

Experiences of fasting during Ramadan in British Muslims: Psychological, social and health behaviours.

Ramadan is a month-long religious festival observed by Muslim worldwide, characterised by intermittent fasting. This qualitative study addressed the need to understand how fasting is experienced by Muslims residing in Western cultures, aiming to inform policies that create a more supportive environment. Practicing Muslims, both men and women, were recruited in the North of England in the United Kingdom (UK).

Broiler farming and antibiotic use through an agency theory lens. A case study from West Bengal, India.

Chicken meat (broiler) production is a rapidly growing livestock sector in India, and one dominated by contract farming. Studies have reported high levels of antibiotic use in Indian broiler farms which is concerning given this is one of the driving forces for the development of antibiotic resistance. This study used the economic lens of agency theory to examine strategic decisions which occur during contract broiler production and their potential impact on antibiotic use, using West Bengal as a case study.

Recruitment, follow-up and survival in an 11-country cohort study of patients at the end of life and their relatives.

Background: Large, international cohort studies generate high-level evidence, but are resource intense. In end-of-life care such studies are scarce. Hence, planning for future studies in terms of data on screening, recruitment, retention and survival remains a challenge.