1,130,990 results match your criteria: "United Kingdom; Translational and Clinical Research Institute[Affiliation]"

Background: For women at low risk of complications during labour and birth, in the United Kingdom, planned birth in a 'community' setting (at home or a freestanding midwifery unit) is generally safe, and intrapartum emergencies are uncommon. Limited exposure may affect midwives' experience of managing an emergency.

Aim: Identify and synthesise available evidence about midwives' experiences of managing intrapartum emergencies during labour in a community setting.

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Objective: The effectiveness and optimal stimulation site of deep brain stimulation (DBS) for central poststroke pain (CPSP) remain elusive. The objective of this retrospective international multicenter study was to assess clinical as well as neuroimaging-based predictors of long-term outcomes after DBS for CPSP.

Methods: The authors analyzed patient-based clinical and neuroimaging data of previously published and unpublished cohorts from 6 international DBS centers.

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High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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Measurement of CP Violation Observables in D^{+}→K^{-}K^{+}π^{+} Decays.

Phys Rev Lett

December 2024

Institute of Physics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Article Synopsis
  • The study investigates CP symmetry violation in the decay of D^{+} particles into K^{-}K^{+}π^{+} using data from proton-proton collisions at a high energy of 13 TeV.
  • A unique model-independent method was employed to analyze the phase-space distributions of D^{+} and D^{-} particles, correcting for any instrumental biases using D_{s}^{+} decays.
  • The findings indicate no significant evidence of CP violation, with a p value of 8.1%, and measure specific CP asymmetry observables, marking this study as the most sensitive search of its kind in multibody decays.
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Interacting Dark Energy after DESI Baryon Acoustic Oscillation Measurements.

Phys Rev Lett

December 2024

School of Mathematics and Statistics, University of Sheffield, Hounsfield Road, Sheffield S3 7RH, United Kingdom.

Article Synopsis
  • The study examines how baryon acoustic oscillations data from the Dark Energy Spectroscopic Instrument affects interacting dark energy (IDE) models, which suggest an energy transfer between dark matter and dark energy.
  • By integrating data from Planck-2018 and the Dark Energy Spectroscopic Instrument, researchers find a noticeable preference for interactions, leading to a present-day expansion rate that alleviates existing tensions with other measurements.
  • Although the IDE model offers a compelling explanation for various observational data and presents compatible expansion rates, it does struggle with predictions related to the overall matter density and large-scale structures in the universe.
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Studying the properties and phase diagram of iron at high-pressure and high-temperature conditions has relevant implications for Earth's inner structure and dynamics and the temperature of the inner core boundary (ICB) at 330 GPa. Also, a hexagonal-closed packed to body-centered cubic (bcc) phase transition has been predicted by many theoretical works but observed only in a few experiments. The recent coupling of high-power laser with advanced x-ray sources from synchrotrons allows for novel approaches to address these issues.

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  • Many experimental setups in quantum science rely on laser fields for controlling states, but this control can suffer from issues related to optical phase noise.
  • Researchers introduced an optical feedforward technique to minimize laser phase noise during the stimulated Raman adiabatic passage for transferring ultracold RbCs molecules.
  • After conducting over 100 transfers on individual molecules, they achieved a notable transfer efficiency of 98.7(1)%, which is primarily constrained by the intensity of the lasers used.
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Research Participants' Engagement and Retention in Digital Health Interventions Research: Protocol for Mixed Methods Systematic Review.

JMIR Res Protoc

January 2025

Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group, Uppsala University, Uppsala, Sweden.

Background: Digital health interventions have become increasingly popular in recent years, expanding the possibilities for treatment for various patient groups. In clinical research, while the design of the intervention receives close attention, challenges with research participant engagement and retention persist. This may be partially due to the use of digital health platforms, which may lack adequacy for participants.

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Background: Virtual follow-up (VFU) has the potential to enhance cancer survivorship care. However, a greater understanding is needed of how VFU can be optimized.

Objective: This study aims to examine how, for whom, and in what contexts VFU works for cancer survivorship care.

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Objective: Brainstem cavernous malformations (BSCMs) were once considered inoperable. Microsurgical resection now represents a valuable option for treating patients with hemorrhagic or symptomatic lesions. The aim of this study was to provide a practical guide for surgical planning by analyzing postoperative neurological and functional outcomes.

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Background And Objective: Relevant research has provided valuable insights into risk factors for bicycle crashes at intersections. However, few studies have focused explicitly on three common types of bicycle crashes on road segments: overtaking, rear-end, and door crashes. This study aims to identify risk factors for overtaking, rear-end, and door crashes that occur on road segments.

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Phytometabolites, Pharmacological Effects, Ethnomedicinal Properties, and Bioeconomic Potential of Velvet Apple (Diospyros discolor Willd.): A Review.

Chem Biodivers

January 2025

Liverpool John Moores University, Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Diospyros discolor Willd., commonly known as Velvet apple or Mabolo, is an underutilized fruit. Traditionally, various parts of D.

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The present study investigated the influence of emotional stimuli in the flanker task. In six experiments, separate influences of anticipating and reacting to valence-laden stimuli (affective pictures or facial expressions) on the flanker effect and its sequential modulation (also known as conflict adaptation) were examined. The results showed that there was little evidence that emotional stimuli influenced cognitive control when positive and negative stimuli appeared randomly during the flanker task.

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The concept of 'resilience' is pervasive, permeating academic disciplines and political discourses. This paper considers (i) the construal of 'resilience' in the contexts of food insecurity and cost-of-living in governmental discourses in the United Kingdom (UK); (ii) to what extent the political representations are reflected in research funding calls of UK national funding bodies, thus showing possibility of shaping research agendas; and (iii) to what extent official uses of 'resilience' reflect lay understandings. We are combining a corpus-based discourse analysis of UK governmental discourses and research funding calls with a study of focus group discussions.

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Background: Poststroke depression (PSD) is a highly prevalent and serious mental health condition affecting a significant proportion of stroke survivors worldwide. While its exact causes remain under investigation, managing PSD presents a significant challenge.

Aim: This study aimed to evaluate the prevalence and predictors of depression among Bangladeshi stroke victims.

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Human brain dynamics are shaped by rare long-range connections over and above cortical geometry.

Proc Natl Acad Sci U S A

January 2025

Centre for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona 08018, Spain.

Article Synopsis
  • A topological principle suggests that the physical structure of the brain (its anatomy) significantly influences its functional dynamics.
  • Researchers found that while local connectivity patterns can explain much of brain function, they overlook the essential role of rare long-range cortical connections, which enhance information processing.
  • By incorporating both local connections and these rare long-range connections into a combined model (EDR+LR), they showed that this approach more effectively captures the complexities of brain activity compared to traditional geometric representations.
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Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial dysfunction. However, the mechanism by which EndoG regulates mitochondrial function is not known.

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Characterizing the feeding ecology of threatened species is essential to establish appropriate conservation strategies. We focused our study on the proboscis monkey (Nasalis larvatus), an endangered primate species which is endemic to the island of Borneo. Our survey was conducted in the Lower Kinabatangan Wildlife Sanctuary (LKWS), a riverine protected area that is surrounded by oil palm plantations.

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Epithelial cancers are typically heterogeneous with primary prostate cancer being a typical example of histological and genomic variation. Prior studies of primary prostate cancer tumour genetics revealed extensive inter and intra-patient genomic tumour heterogeneity. Recent advances in machine learning have enabled the inference of ground-truth genomic single-nucleotide and copy number variant status from transcript data.

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  • The study explored the effects of a specific enzyme (FAEA) expressed in maize that targets the apoplast, focusing on its activity during the late stages of plant senescence and after storing the plant material.
  • FAEA levels increased until the reproductive (R) stage but dropped during full leaf senescence (R+), while the enzyme remained stable even after six months of cold storage.
  • The research found that FAEA expression led to decreased cell wall components like ferulates and improved the breakdown (saccharification) of plant material by enzymes, making it easier to extract sugars at later development stages.
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  • Understanding plant growth is crucial, especially with restrictions like COVID-19 hindering field studies, making modeling a valuable tool for predicting plant performance in limited conditions.
  • The study focused on rubber plants grown in two types of acidic soils treated with different magnesium sources, assessing their growth through metrics like height, stem diameter, and biomass, using specific mathematical models to analyze growth rates.
  • Results indicated that magnesium-rich synthetic gypsum (MRSG) significantly enhanced rubber seedling growth compared to other treatments, especially in Ultisol soil, suggesting MRSG could effectively replace traditional magnesium fertilizers for sustainable growth.
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Forests face an escalating threat from the increasing frequency of extreme drought events driven by climate change. To address this challenge, it is crucial to understand how widely distributed species of economic or ecological importance may respond to drought stress. In this study, we examined the transcriptome of white spruce (Picea glauca (Moench) Voss) to identify key genes and metabolic pathways involved in the species' response to water stress.

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Background: Despite the comparatively high prevalence of possible sarcopenia among young-old adults in the community, there is currently no available and effective social media-based intervention to increase the awareness and change the behavior of the target population to prevent sarcopenia. Using co-design methodology, we developed a multicomponent intervention strategy of health education and exercise for sarcopenia prevention utilizing the TikTok platform.

Objectives: The primary purpose of this study is to examine the feasibility and acceptability of the social media-based intervention to enhance muscle function in community-dwelling young-old adults with possible sarcopenia.

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  • The study investigates the role of reflective practice groups in inpatient mental health settings, focusing on their impact on staff well-being and clinical practice amidst staff shortages.
  • Interviews with fifteen participants revealed that these groups can enhance staff reflection and team cohesion, while factors like group composition and support for facilitators can influence engagement.
  • The findings suggest actionable changes to improve staff participation in these groups and emphasize the need for further research on their effectiveness in mental health care.
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Hostile, discriminatory, and violent behavior within the creative industries has attracted considerable public interest and existing inequalities have been discussed broadly. However, few empirical studies have examined experiences of hostile behavior in creative higher education and associated mental health outcomes of early career artists. To address this gap, we conducted a survey among individuals studying at higher education institutions for art and music (N = 611).

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