1,129,127 results match your criteria: "United Kingdom; Newcastle Upon Tyne Hospitals NHS Foundation Trust[Affiliation]"
Psychopharmacology (Berl)
December 2024
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Rationale: Working memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclinical data suggest histamine-3 receptor (H3R) expression in cortical pyramidal neurons may have a role in working memory, and post-mortem data has found disruptions of H3R expression in schizophrenia.
Objectives: We examined the role of H3R in vivo to elucidate its role on working memory impairment in schizophrenia.
BMC Med
December 2024
Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology & Population Health, London, School of Hygiene and Tropical Medicine, London, UK.
Background: Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared with an older alternative, warfarin using primary care data in the United Kingdom (UK). However, other studies observed contradictory findings. We therefore aimed to investigate the association between mortality and warfarin, compared with DOACs.
View Article and Find Full Text PDFBMC Womens Health
December 2024
Department of Psychology, University of Sheffield, Sheffield, UK.
Background: The prevalence of domestic abuse is greater in times of humanitarian crisis, and the COVID-19 pandemic has been no different. Considerable evidence indicates that domestic abuse disproportionately impacts the mental health and wellbeing of racially Minoritised women. The present study aimed to explore racially Minoritised women's experiences of domestic abuse and mental health in the COVID-19 pandemic in the UK.
View Article and Find Full Text PDFBr J Psychiatry
December 2024
Population Health Sciences, Bristol Medical School, University of Bristol, UK.
Background: Trace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis.
Aims: To evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of animal and human studies, and provide recommendations for future research prioritisation.
Method: This study is part of GALENOS (Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis).
Cereb Cortex
December 2024
Institute of Computer Science, University of Bern, 3012 Bern, Switzerland.
Foreseeing the future outcomes is the art of decision-making. Substantial evidence shows that, during choice deliberation, the brain can retrieve prospective decision outcomes. However, decisions are seldom made in a vacuum.
View Article and Find Full Text PDFNurs Health Sci
December 2024
School of Nursing, Fudan University, Shanghai, China.
Understanding the relationships between comorbidity, disability, and home health-care services aids in user-centered care design. This study identifies patterns of these factors among older adults with physical disability living at home and explores their associations. This cross-sectional study included community-dwelling older adults assessed for Long-term Care Insurance from September 1 to December 31, 2018, in Yiwu, Zhejiang, China.
View Article and Find Full Text PDFClin Teach
February 2025
Centre for Medical Education, Queen's University Belfast, Belfast, UK.
Background: Objective structured clinical examinations (OSCEs) are used globally to assess health professional learners' clinical skills and applied knowledge. Despite innovations with simulated participants, manikin technology and real patient involvement, there remains a gap between 'real-life' practice and 'OSCE experience'. For example, although mobile phone use is increasingly common in clinical practice; however, it would represent a significant disruption to established assessment practices in OSCEs.
View Article and Find Full Text PDFInfect Dis Clin North Am
December 2024
Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, Sacramento, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA; UC-Davis Center for Valley Fever. Electronic address:
Coccidioidomycosis is the clinical disease caused by the dimorphic pathogenic fungi Coccidioides immitis and C posadasii. The number of clinically recognized coccidioidomycosis cases continues to increase yearly including in regions outside the traditional regions of endemicity. Following inhalation of Coccidioides spores, the course may range from asymptomatic exposure with resultant immunity, to a subacute pulmonary illness, to life-threatening disseminated infection.
View Article and Find Full Text PDFPrim Care Diabetes
December 2024
School of Population Health, University of Auckland, Auckland, New Zealand. Electronic address:
Aims: This large population-based study aimed to investigate whether arterial stiffness, assessed oscillometrically, was associated with incident diabetes/prediabetes.
Methods: The study sample comprised 4240 participants from the Vitamin D Assessment (ViDA) Study (mean±SD age = 66 ± 8). Arterial stiffness was assessed from 5 April 2011-6 November 2012 by way of aortic PWV (aPWV) and estimated carotid-femoral PWV (ecfPWV).
Clin Teach
February 2025
Medical Education Innovation & Research Centre, Department of Primary Care and Public Health, School of Public Health, Imperial College London, UK.
Background: United Kingdom Queer medical students' experiences have only been explored in depth in one previous study, despite longstanding calls to address National Health Service queerphobia. The study aims to combine our participants' data with personal insights from the Queer medical student research team to both record Queer medical students' experiences and provide practical actions that can promote support, inclusivity and celebration for Queer medical students.
Methods: Individual semi-structured interviews were conducted with 12 participants across three medical schools in England and Scotland.
Clin Teach
February 2025
Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Background: There remains a lack of diversity among those pursuing clinical academic careers. Structural inequalities, discrimination and a paucity of relatable role models can disadvantage minoritised students, hindering their educational experiences and career opportunities. Innovative and effective approaches are needed at an undergraduate level to address this problem, ensuring the pipeline is representative, diverse and inclusive.
View Article and Find Full Text PDFJ Sch Psychol
February 2025
School of Psychology, University of Sussex, UK.
We trialed a novel method aimed at reducing educational inequalities in any given school by tailoring an intervention to address the specific local social, cultural, and psychological barriers that contribute to those inequalities. In Study 1 (N = 2070), we validated measures in a student survey of barriers experienced by students ages 11-16 years in two schools in England. We used a pilot version of these measures to identify two barriers that appeared to be contributing in both schools to poorer attendance and behavioral records of Black versus Asian students and of lower socioeconomic status (SES) students versus higher SES students.
View Article and Find Full Text PDFJ Allergy Clin Immunol
December 2024
Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Children's Allergy Service, Evelina London Children's Hospital, Guy's and St Thomas' Hospital, London, United Kingdom. Electronic address:
Food allergy is increasing in prevalence, and poses significant challenges for individuals and their families, adversely impacting their quality of life. Misdiagnosis can lead to unnecessary dietary and social limitations, and increased food allergy risk, while failure to diagnose may result in life-threatening anaphylaxis. Therefore, a precise diagnosis is of the utmost importance; however, barriers exist at every stage of the diagnostic process.
View Article and Find Full Text PDFJ Dairy Sci
December 2024
Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States.
The holobiont concept has emerged as an attempt to recognize and describe the myriad interactions and physiological signatures inherent to a host organism, as impacted by the microbial communities that colonize and/or co-inhabit the environment within which the host resides. The field acknowledges and draws upon principles from evolution, ecology, genetics, and biology, and in many respects has been "pushed" by the advent of high throughput DNA sequencing and, to a lesser extent, other "omics"-based technologies. Despite the explosion in data generation and analyses, much of our current understanding of the human and ruminant "holobiont" is based on compositional forms of data and thereby, restricted to describing host phenotypes via associative or correlative studies.
View Article and Find Full Text PDFEnviron Res
December 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address:
Keratoconus is a blinding corneal disorder influenced by genetic factors. Whether environmental factors influence it remains unclear. Here, we observed a U-shaped association between residential greenness and keratoconus, with increased odds ratios (ORs) at low and high greenness levels.
View Article and Find Full Text PDFJ Arthroplasty
December 2024
Department of Orthopedic Surgery, NYU Langone Health, New York, NY.
Biochim Biophys Acta Bioenerg
December 2024
School of Life Sciences, Biochemistry and Biomedicine, University of Sussex, Falmer BN1 9QG, United Kingdom; AlternOx Scientific Ltd, Science Park Square, Brighton BN1 9SB, United Kingdom. Electronic address:
Urology
December 2024
King's College London, London, United Kingdom; Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Electronic address:
Objective: To assess urological complications in patients undergoing total pelvic exenteration (TPE) for locally advanced (LARC) and recurrent rectal cancer (RRC) as publications in this area are limited. Secondary objectives were to assess whether LARC vs RRC or radiation status affected urological outcomes.
Methods: Single-centre, retrospective study of TPE patients between January 2017 and December 2022.
Neurosci Biobehav Rev
December 2024
Cambridge Hearing Group, Department of Psychology, University of Cambridge, Cambridge, United Kingdom; Vision and Eye Research Institute, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, United Kingdom. Electronic address:
Blindness or deafness can significantly influence sensory abilities in intact modalities, affecting communication, orientation and navigation. Explanations for why certain abilities are enhanced and others degraded include: crossmodal cortical reorganization enhances abilities by providing additional neural processing resources; and sensory processing is impaired for tasks where calibration from the normally intact sense is required for good performance. However, these explanations are often specific to tasks or modalities, not accounting for why task-dependent enhancement or degradation are observed.
View Article and Find Full Text PDFAm J Intellect Dev Disabil
January 2025
Elizaveta Dimitrova and Athanasia Kouroupa, University College London, UK; and Vasiliki Totsika, University College London, UK, Centre for Research in Intellectual and Developmental Disabilities, University of Warwick, UK, Tavistock & Portman NHS Foundation Trust, UK, and Millennium Institute for Care Research (MICARE), Chile.
Resilience in families of autistic children and children with intellectual disability is associated with factors such as family functioning, social support, and financial strain. Little is known about family resilience during the COVID-19 pandemic when many resources were limited. This study examined the association of family resilience with child characteristics, family resources, and socioecological factors during the pandemic.
View Article and Find Full Text PDFNeuromuscul Disord
December 2024
The John Walton Muscular Dystrophy Research Centre (JWMDRC), Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom.
Desmoid tumours, also known as aggressive fibromatosis, are rare tumours derived from mesenchymal stem cells, accounting for only 0.03 % of all tumours. While 85-90 % of cases are sporadic, desmoid tumours can occasionally be associated with Gardner syndrome (or Familial Adenomatous Polyposis), which is linked to variants in the tumour suppressor gene, APC (adenomatous polyposis coli) gene on chromosome 5.
View Article and Find Full Text PDFGait Posture
December 2024
The Robert Jones and Agnes Hunt Orthopaedic Hospital, NHS Foundation Trust, Oswestry, SY10 7AG, United Kingdom; School of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent, ST4 7QB. Electronic address:
Background: Electromyography (EMG) can estimate the magnitude and timing of muscle activation during walking in those with gait disorders. Despite the potential of EMG use in assessment and clinical decision-making, there are reports of declining use of EMG within gait laboratories. Technical and educational barriers to EMG usage in clinics in Italy were recently suggested.
View Article and Find Full Text PDFG3 (Bethesda)
December 2024
MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, United Kingdom, EX4 4QD.
Batrachochytrium dendrobatidis (Bd) is responsible for mass extinctions and extirpations of amphibians, mainly driven by the Global Panzootic Lineage (BdGPL). BdGPL isolate JEL423 is a commonly used reference strain in studies exploring the evolution, epidemiology and pathogenicity of chytrid pathogens. These studies have been hampered by the fragmented, erroneous and incomplete B.
View Article and Find Full Text PDFNon-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) is a chronic disease characterised by progressive inflammatory lung damage due to infection by non-tuberculous mycobacteria (NTM). Global prevalence of NTM-PD is generally low but is rising, likely due to a combination of increased surveillance, increasing multimorbidity and improved diagnostic techniques. Most disease is caused by Mycobacterium avium complex species.
View Article and Find Full Text PDFSci Data
December 2024
Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Department of Ecology, Ceske Budejovice, Czech Republic.
Pathogens significantly influence natural and agricultural ecosystems, playing a crucial role in the regulation of species populations and maintaining biodiversity. Entomopathogenic fungi (EF), particularly within the Hypocreales order, exemplify understudied pathogens that infect insects and other arthropods globally. Despite their ecological importance, comprehensive data on EF host specificity and geographical distribution are lacking.
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