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1,129,396 results match your criteria: "United Kingdom; MRC & Asthma UK Centre for Allergic Mechanisms of Asthma[Affiliation]"
Int J Older People Nurs
January 2025
Department of Nursing Science, University of Turku, Turku, Finland.
Introduction: Nurses' well-being at work (WAW) is important for overall health care outcomes. Nurses often navigate complex roles, contending with time constraints, ethical challenges and societal undervaluation, underscoring the necessity of addressing their WAW.
Methods: The aim of this systematic review was to analyse the interventions that potentially improve nurses' WAW in care settings for older people.
J Vis Commun Med
December 2024
Moletest (Scotland) Ltd, Edinburgh, United Kingdom.
Four versions of the novel Moletest on-device signal-processing analysis software, delivered on a single-application iPadPro11, were evaluated in pigmented skin lesions of patients sent for biopsy comparing its results with the lesion histology. The primary objective was to demonstrate that the nomela test provided at least 95 ± 2% sensitivity for not-melanoma. Proprietary software recognised the lesion perimeter, rejecting images with uncertain border, and performed analysis using non-scalar metrics of the image within the perimeter.
View Article and Find Full Text PDFActa Med Acad
December 2024
Centre for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Zagreb, Croatia. ORCID: 0000-0002-8467-6061.
Objective: This study presents the personal experience of a 19-year-old student who fled the war in Ukraine, journeyed across multiple countries, and ultimately enrolled in a university psychology program in Croatia.
Methods: A collaborative autoethnographic approach was employed to explore the student's experience as a war refugee, traversing Europe, and beginning university life in a foreign country. Data were collected through the student's reflective writing.
Front Cell Infect Microbiol
December 2024
Department of Dentistry, School of Health Sciences, University of Brasília, Brasilia, Brazil.
Virus Evol
November 2024
Department of Biology, University of Maryland, College Park, MD 20742, USA.
The enormous diversity of bacteriophages and their bacterial hosts presents a significant challenge to predict which phages infect a focal set of bacteria. Infection is largely determined by complementary-and largely uncharacterized-genetics of adsorption, injection, cell take-over, and lysis. Here we present a machine learning approach to predict phage-bacteria interactions trained on genome sequences of and phenotypic interactions among 51 strains and 45 phage λ strains that coevolved in laboratory conditions for 37 days.
View Article and Find Full Text PDFVirus Evol
November 2024
Research Laboratory, Botswana Harvard Health Partnership, Gaborone, Private Bag BO 320, Botswana.
Botswana, like the rest of the world, has been significantly impacted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In December 2022, we detected a monophyletic cluster of genomes comprising a sublineage of the Omicron variant of concern (VOC) designated as B.1.
View Article and Find Full Text PDFDeep learning models are used to minimize the number of polyps that goes unnoticed by the experts and to accurately segment the detected polyps during interventions. Although state-of-the-art models are proposed, it remains a challenge to define representations that are able to generalize well and that mediate between capturing low-level features and higher-level semantic details without being redundant. Another challenge with these models is that they are computation and memory intensive, which can pose a problem with real-time applications.
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
St Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
We report a rare case of a rapidly growing and large conjunctival histoplasmosis lesion in an immunosuppressed West African woman in her 80s, affecting her only eye. The patient had undergone a renal transplant and was on immunosuppressive medications. Additionally, she had previously been treated for presumed systemic histoplasmosis with itraconazole more than 5 years ago.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
Malawi-Liverpool Wellcome Programme, Blantyre, Malawi.
Background: Infections and sepsis are leading causes of morbidity and mortality in women during pregnancy and the post-pregnancy period. Using data from the 2017 WHO Global Maternal Sepsis Study, we explored the use of early warning systems (EWS) in women at risk of sepsis-related severe maternal outcomes.
Methods: On April 27, 2023, we searched the literature for EWS in clinical use or research in obstetric populations.
J Ultrason
December 2024
Paediatrics, Azienda Ospedaliera Sant'Andrea, Roma, Italy.
Aim: Aiming to offer a diagnostic tool to aid examiners with correct hip typing and decision-making about patient management, members of the Board of the International Interdisciplinary Consensus Committee on DDH Evaluation (ICODE - https://www.icode.expert), introduced the cross-platform mobile application (Android and iOS) called "ICODE Hip US Calculator".
View Article and Find Full Text PDFFront Psychiatry
December 2024
Department of Neuroscience, University of Padua, Padua, Italy.
Dementia with Lewy bodies (DLB) and its prodromal presentation with mild cognitive impairment is characterized by prominent deficits in attention/executive domains and in visual processing abilities with relative sparing of memory. Neuropsychological research is continuously refining the tools to define more in detail the patterns of relatively preserved and impaired cognitive abilities that help differential diagnosis between DLB and Alzheimer disease (AD). This review summarizes the main studies exploring specific cognitive tasks investigating different visual processing abilities and verbal memory that better differentiate DLB from AD.
View Article and Find Full Text PDFFront Psychiatry
December 2024
Department of Psychology, Sapienza University of Rome, Rome, Italy.
Introduction: With ageing there are changes in the ability to orient attention, which affect more endogenous than exogenous orienting. However, orienting attention by the gaze direction of others shares characteristics of both exogenous and endogenous attention and it is unclear how it is affected by ageing. Being able to orient attention by the gaze direction of others is important to establish successful social interactions (i.
View Article and Find Full Text PDFEClinicalMedicine
December 2024
Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Background: Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD and major depressive disorder (MDD) are associated with the development of cognate TBI-related phenotypes.
Methods: Meta-analyses were conducted using data from two multicenter, prospective observational cohort studies of patients with mTBI: the CENTER-TBI study (ClinicalTrials.
Pan Afr Med J
December 2024
Division of Population Health, Sheffield Centre for Health and Related Research, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Introduction: Gavi, the Vaccine Alliance, defined a transition roadmap for countries receiving funding support based on their income status projections. According to the latest projections, Kenya will complete their transition from vaccine funding in 2029. While eligible countries are kept informed and supported for a smooth transition process, the extent to which countries understand the significant implications of a complete end of GAVI support on immunization service delivery varies.
View Article and Find Full Text PDFScientificWorldJournal
December 2024
Department of Biological and Environmental Sciences, Faculty of Natural Sciences, Walter Sisulu University, Nelson Mandela Drive Campus, P/Bag X1, Mthatha 5117, Eastern Cape, South Africa.
Invertebrates form a vital component of agricultural ecosystems, and they are chief actors in sustaining the functions of the ecosystem and soil health. Scholarly publications that concentrated on visualizing the research outputs and trends on invertebrates and agriculture are scarce. In this paper, we adopted a bibliometric model to extract trends/research studies on invertebrates and agriculture between 1991 and 2022, using scholarly studies retrieved from the Web of Science (WoS) databank.
View Article and Find Full Text PDFFront Pain Res (Lausanne)
December 2024
Anesthesiology, University of California, San Diego, CA, United States.
The neuraxial delivery of drugs for the management of pain and other spinal pathologies is widely employed and is the subject of a large volume of ongoing research with several thousand papers appearing in the past 5 years alone on neuraxial delivery. Several learned texts have been recently published. A number of considerations have contributed to this widespread interest in the development of the use of neuraxial therapeutics to manage pain.
View Article and Find Full Text PDFPNAS Nexus
January 2025
Department of Sociology, University of Oxford, Oxford OX1 1JD, United Kingdom.
Worldwide, mortality was strongly affected by the COVID-19 pandemic, both directly through COVID-19 deaths and indirectly through changes in other causes of death. Here, we examine the impact of the pandemic on COVID-19 and non-COVID-19 mortality in 24 countries: Australia, Austria, Brazil, Bulgaria, Canada, Chile, Croatia, Czechia, Denmark, England and Wales, Hungary, Japan, Latvia, Lithuania, The Netherlands, Northern Ireland, Poland, Russia, Scotland, South Korea, Spain, Sweden, Switzerland, and the United States. Using demographic decomposition methods, we compare age- and cause-specific contributions to changes in female and male life expectancy at birth in 2019-2020, 2020-2021, and 2021-2022 with those before the COVID-19 pandemic (2015-2019).
View Article and Find Full Text PDFeNeurologicalSci
March 2025
Department of Cognitive Neurology, Fleni, Montañeses 2325 (C1428AQK), Buenos Aires, Argentina.
Background: This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with SARS-CoV-2experience more pronounced deterioration compared to those who are uninfected.
Methods: Research from 01/03/2020 to 07/10/2023 was conducted using Medline, Web of Science, and Embase databases, and adhering to PRISMA guidelines and the PICO framework.
Heliyon
December 2024
Anglia Ruskin University, Writtle School of Agriculture, Animal and Environmental Sciences, Lordship Road, Chelmsford, CM1 3RR, United Kingdom.
The purpose of this study was to identify the effects of four heights of cavaletti exercise on canine kinematics and kinetics. Eight dogs had kinematics and kinetics data collected whilst completing cavaletti pole exercises at four different heights (floor, mid-metatarsal, hock, and stifle). Dogs had anatomical markers placed on bony landmarks of the fore and hindlimb joints.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Low temperature is the main strategy to preserve fruit quality post-harvest, in the supply chain. Low temperatures reduce the respiration, ethylene emission, and enzymatic activities associated with senescence. Unfortunately, peaches are sensitive to low temperatures if exposed for long periods, resulting in physiological disorders that can compromise commercial quality.
View Article and Find Full Text PDFJ Biomed Opt
December 2024
University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom.
Significance: Current super-resolution imaging techniques allow for a greater understanding of cellular structures; however, they are often complex or only have the ability to image a few cells at once. This small field of view (FOV) may not represent the behavior across the entire sample, and manual selection of regions of interest (ROIs) may introduce bias. It is possible to stitch and tile many small ROIs; however, this can result in artifacts across an image.
View Article and Find Full Text PDFInt J Stroke
December 2024
Division of Neurology, McMaster University, Hamilton, ON, Canada.
Background: Secondary stroke prevention in patients with atrial fibrillation (AF) is one of the fastest growing areas in the field of cerebrovascular diseases. This Scientific statement from the World Stroke Organization Brain & Heart Task Force provides a critical analysis of the strength of current evidence this topic, highlights areas of current controversy, identifies knowledge gaps, and proposes priorities for future research.
Methods: We select topics with the highest clinical relevance and perform a systematic search to answer specific practical questions.
Chin Med J (Engl)
December 2024
Keele Cardiovascular Research Group, Institute for Prognosis Research, University of Keele, Keele, ST5 5BG, United Kingdom.
This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their impact on prognosis. Although cancer survival rates have improved over the last two decades, the risk of CVD has risen over time in patients with cancer.
View Article and Find Full Text PDFAnn Work Expo Health
December 2024
HSE Science Division, Health and Safety Executive's Science and Research Centre, Harpur Hill, Buxton SK17 9JN, United Kingdom.
Desktop three-dimensional (3D) printers are used in businesses, schools, and colleges, and are generally of an unenclosed design which may give rise to injuries or inhalation exposure to emissions of small particles (<1 µm) and volatile organic compounds (VOCs). The aim of this work was to explore the health risks related to the use of desktop 3D printers in workplaces in the United Kingdom. A digital survey on the use of desktop 3D printers was completed voluntarily and anonymously between February and June 2023, receiving 146 responses.
View Article and Find Full Text PDFEye (Lond)
December 2024
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Objectives: To determine the association between telomere length (TL) and age-related macular degeneration (AMD) and examine the potential variations with sex and ethnicity.
Methods: Population-based, cross-sectional study. A total of 52,083 participants from the UK Biobank were included.