Interdisciplinary Care for Geriatric Syndromes in Chronic Kidney Disease: A Qualitative Study.

Background: Despite their prevalence, prognostic significance, and prioritization by patients, key geriatric syndromes, such as cognitive impairment, frailty, and depression are not routinely addressed in chronic kidney disease (CKD) care in the United States (US). In an interdisciplinary care model, health professionals with diverse expertise collaborate to address all symptoms and functional impairments occurring alongside a patient's chronic disease. Thus, routinely addressing geriatric syndromes in CKD may require implementing this evidence-based model of care and adapting it to the needs of patients with CKD.

Versatile C-H alkylation and alkylidenation via catalytic alkylidene transfer of enones.

The alkylidene transfer reactions of alkenes are of particular significance but challenging. Here, we report that enones can serve as diverse alkylidene sources for catalyst-controlled selective C-H alkylation and/or alkylidenation of various nucleophiles. Treatment of a mixture of ketone (or lactam), enone and diarylmethanol with a catalytic amount of Y[N(TMS)2]3, gave the corresponding α-C-H bond alkylation products derived from the alkylidene transfer from enones to ketones/lactams, whereas the reaction of enones with various C-nucleophiles in the presence of KOH as a catalyst resulted in C-H alkylidenation.

The Incomplete V-Y Flap: A Useful Design Modification of the Conventional V-Y Flap Exampled With a Case Series of Pilonidal Sinus Excision Defects.

Pilonidal disease is relatively common and can be particularly comorbid for patients, especially in circumstances of chronic abscess or sinus formation. Excision of such disease can require flap reconstruction, one of the most common types being V-Y advancement flap. We present a modification of the V-Y flap that leaves incompletely incised distal edges that theoretically will help to avoid flap tip necrosis while allowing sufficient tissue mobility.

Course Review: Surgical Art Hand Fracture Fixation Course August 2024.

Hand fracture management is an important skill for both plastic and orthopedic surgery, which is often not practiced during early surgical training. Simulation training can be used to supplement clinical practice. The Surgical Art Hand Fracture Fixation course is a 2-day course based in Liverpool that aims to teach the principles of stabilization and fixation of hand fractures.

Burnout in medical and performance professionals working in elite football in the United Kingdom: a pilot study.

Background: Despite the focus on the effect of burnout on athlete health and performance, understanding its impact on their support teams remains limited. Our primary aim was to investigate the prevalence of burnout amongst medical and performance professionals working in professional football in the UK.

Methods: In this cross-sectional design study burnout risk was assessed using the Burnout Assessment Tool-23 (BAT-23).

Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC.

Animal models offer invaluable insights into disease mechanisms but cannot entirely mimic the variability and heterogeneity of human populations, nor the increasing prevalence of multi-morbidity. Consequently, employing human samples-such as whole blood or fractions, valvular and vascular tissues, myocardium, pericardium, or human-derived cells-is essential for enhancing the translational relevance of cardiovascular research. For instance, myocardial tissue slices, which preserve crucial structural and functional characteristics of the human heart, can be used in vitro to examine drug responses.

Simon Doherty.

A popular, intelligent, influential, inspirational and much-loved vet. Simon was well known, respected and popular with the professionals he supported, represented, mentored and learnt from.

The Horserace Betting Levy Board codes of practice: past and present.

The 2025 horse breeding season sees the release of the 49th consecutive edition of the Horserace Betting Levy Board Codes of Practice for the prevention and control of specified infectious diseases. In this article, Sidney Ricketts, James Crabtree and Richard Newton describe how the first edition of the codes came about in 1977 and their evolution over the past five decades.

'Save Cambridge vet school' rally held.

Despite a decision by university bosses to continue provision for Cambridge's vet school, questions remain over the institution's future. In this special report, Josh Loeb hears from those rallying to save it.

Ensuring parasiticides hit their targets.

With increasing concern about the impact some conventional parasiticides have on non-target species, efforts are underway to develop species-specific alternatives. Josh Loeb reports.

Impact of Rurality and Geographical Accessibility on Stroke Care and Outcomes.

Background: Providing equitable health care to rural stroke patients is challenging and associated with less intervention and poorer outcomes. We assessed how several distinct patient-related geographic classifications influenced stroke care and outcomes in Scotland, United Kingdom.

Methods: We conducted a population-level data-linkage study of ischemic stroke patients admitted to the hospital (2010-2018).

Genetic Insights Into Hemorrhagic Stroke and Vascular Malformations: Pathogenesis and Emerging Therapeutic Strategies.

Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Understanding the genetic basis of these malformations is critical for uncovering underlying mechanisms, developing targeted prevention strategies, and identifying novel therapeutic targets. This review highlights the causal genes and signaling pathways in AVMs, CCMs, and intracranial aneurysms, noting both their commonalities and differences.

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors.

Chronic liver injury characterized by unresolved hepatitis leads to fibrosis, potentially progressing to cirrhosis and hepatocellular carcinoma. Effective treatments for halting or reversing liver fibrosis are currently lacking. This study investigates the potential of HDAC6 as a therapeutic target in liver fibrosis.

Systematic review of pharmacotherapy for atypical facial pain: evaluation of pain reduction, depression, anxiety and quality of life.

Background/purpose: Atypical facial pain (AFP) is a chronic condition characterized by persistent facial pain without clear clinical signs, making diagnosis and treatment difficult. Common pharmacological treatments include antidepressants, anticonvulsants and neuromodulators, but their effectiveness remains uncertain, necessitating a systematic review to guide clinical practice.

Materials And Methods: Following PRISMA 2020 guidelines, randomized controlled trials (RCTs) evaluating pharmacological treatments for AFP in adults were included.

Engineering Aqueous Electrolytes with Vicinal S-based Organic Additives for Highly Reversible Zinc-Ion Batteries.

The commercial deployment of Aqueous Zinc Ion Batteries (AZIBs) is hampered by dendrites, the hydrogen evolution reaction (HER) and corrosion reactions. To tackle these challenges, we have introduced 3,3'-dithiobis-1-propanesulfonic acid disodium salt (SPS), a symmetrical sulfur-based organic salt, as an electrolyte additive for AZIBs. Unlike conventional electrolyte additives that favour (002) deposition, SPS enables dense (100) growth through a unique symmetrically aligned concentration-controlled adsorption network, affording structural uniformity and compactness to the Zn deposit layer.

Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024.

We report two importations of monkeypox virus clade Ib infection to the United Kingdom in 2024. The first was a traveller returning from Tanzania, Rwanda and Uganda, the second from Uganda. Both presented with fever and typical skin lesions; 147 contacts were followed up, 19 vaccinated with MVA-BN.

Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges.

The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA.

The regulation on the use of supplements for weight control: Case studies from Australia, the United States of America, and the United Kingdom.

Background: Overweight and obesity have become more prevalent worldwide which has led to an increase in the demand for non-prescribed weight loss supplements. Given that these products are loosely regulated, they are often misused by adolescents and young adults.

Objective: This study aims to review regulatory policies for weight loss supplements in Australia, the United States, and the United Kingdom to identify areas for improvement.

The acceptability of compassion-focused therapy in clinical populations: a metasynthesis of the qualitative literature.

Background: Compassion-focused therapy (CFT) is a psychological intervention that is increasingly used in UK NHS services, either in an individual or a group format, with individuals experiencing psychological difficulties. Reviews of the quantitative evidence suggest that CFT effectively improves psychological well-being in various clinical groups. Participant experiences of group CFT in those with psychological difficulties have also been explored in several published qualitative and mixed-methods studies.

Risks to the clinician of risk management: recalled and anticipated consequences of decision-making.

Background: Despite extensive literature studying how we make decisions in the face of uncertainty, the empirical study of real-world clinical decision-making in mental health practice remains limited. Decisions in clinical settings are not just made on the basis of clinical factors. A key non-clinical influence on decision making is the clinician's concerns about the 'threat' to themselves from a future adverse incident and the subsequent retrospective scrutiny of their decision-making.

Catalyst Activation and Speciation Involving DyadPalladate Precatalysts in Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings.

Understanding mechanisms underpinning Pd precatalyst activation and formation of active species is important in maximizing catalyst activity and lifetime. DyadPalladate precatalysts, represented by the general formula [RPH][PdCl] (RP = tertiary alkylphosphine/arylphosphines), have recently emerged as sustainable, active Pd precatalysts for cross-couplings (e.g.

Ketogenic metabolic therapy in the remission of chronic major depressive disorder: a retrospective case study.

Background: There is limited evidence describing the use of ketogenic metabolic therapy (KMT), also known as a ketogenic diet (KD), to achieve full remission of treatment-resistant major depressive disorder (MDD) in real-world clinical settings. This case study examines a 47-year-old woman with lifelong treatment-resistant MDD who achieved complete remission of depressive symptoms and improved functioning through a ketogenic diet.

Methods: The patient engaged in KMT with a 1.

Explainable AI in medical imaging: an interpretable and collaborative federated learning model for brain tumor classification.

Introduction: A brain tumor is a collection of abnormal cells in the brain that can become life-threatening due to its ability to spread. Therefore, a prompt and meticulous classification of the brain tumor is an essential element in healthcare care. Magnetic Resonance Imaging (MRI) is the central resource for producing high-quality images of soft tissue and is considered the principal technology for diagnosing brain tumors.