Validation of the PANAMA-Score for Survival and Benefit of Adjuvant Therapy in Patients with Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX.

Aim: To validate the prognostic value of the PAncreatic NeoAdjuvant MAssachusetts (PANAMA)-score and to determine its predictive ability for survival benefit derived from adjuvant treatment in patients after resection of pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant FOLFIRINOX.

Background: The PANAMA-score was developed to guide prognostication in patients after neoadjuvant therapy and resection for PDAC. As this score focuses on the risk for residual disease after resection, it might also be able to select patients who benefit from adjuvant after neoadjuvant therapy.

Experimental support for partial compensation, not matched, partner response rules in blue tits.

Outcomes of theoretical models on conflict resolution between investing partners in bi-parental care systems typically predict "partial compensation" or "matched" response rules, depending on underlying assumptions. Further, although experimental tests in birds suggest that care levels by pair members are largely associated with partial compensation responses, this outcome partly depends on the type of experiment used and its effects on model assumptions. To elucidate support for both the underlying assumptions and predictions of models predicting partner compensation versus matching, we performed temporary, bi-directional brood size manipulations during late nestling provisioning in blue tits () in the French Pyrenees.

Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study.

Objective: In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA in a formal screening study. We report a systematic community-based assessment of the prevalence of prostate MRI lesions in an age-selected population.

Collaborating for Impact: Navigating Partnerships and Overcoming Challenges across the Sustainable Development Goals.

We illustrate the importance of early career perspectives and diverse partnerships to develop solutions and overcome key challenges to achieve the Sustainable Development Goals.

Susceptibility patterns of species collected from intensive care units in Portugal: a prospective study in 2020-2022.

Background: For infections antifungal therapy is often empirical and mainly depends on locally antifungal surveillance data, which differs between geographic regions.

Aims: To monitor the epidemiology and antifungal susceptibility of spp. from combined axillar-groin samples in intensive care unit (ICU) patients on admission (day1, D1), day 5 (D5) and day 8 (D8).

Reinforcing Bulk Heterojunction Morphology through Side Chain-Engineered Pyrrolopyrrole-1,3-dione Polymeric Donors for Nonfullerene Organic Solar Cells.

Organic solar cells (OSCs) are attracting significant attention due to their low cost, lightweight, and flexible nature. The introduction of nonfullerene acceptors (NFAs) has propelled OSC development into a transformative era. However, the limited availability of wide band gap polymer donors for NFAs poses a critical challenge, hindering further advancements.

Use of Historical Cricket Scorecards to Accurately Map Effort Tolerance in Untreated Congenital Heart Disease.

This case report describes rare accurate historical documentation of progressive reduction in effort tolerance over time in a patient with untreated congenital heart disease and pulmonary hypertension.

Rotational Atherectomy to Treat in-Stent Recurrent Protruding Calcified Nodule.

A 73-year-old man presented with acute coronary syndrome secondary to stent failure. Intravascular imaging identified a recurrent protruding calcific nodule as the mechanism, which was effectively treated with low-speed rotablation, resulting in ablation of the nodule allowing the application of a drug-coated balloon.

Porcelain Aorta and Radiation-Induced Mitral Annular Calcification Are Not Contraindications to Surgery.

We describe the case of a 52-year-old man with radiation-induced severe mixed aortic and mitral valve disease, thickening of the aortomitral continuity, mitral annular calcification, and porcelain aorta with limited transcatheter treatment options. By replacing the aorta during circulatory arrest, we demonstrate that it is possible to clamp the ascending aorta to facilitate prosthetic aortic and mitral valve replacement.

Manipulating self and other schemas to explore psychological processes associated with paranoid beliefs: an online experimental study.

Background: Information about the self and others is organized in cognitive-affective structures that influence and guide interpersonal behavior. These structures are referred to as relational schemas and are thought to be influenced by early interpersonal experiences with significant others leading to secure or insecure attachment patterns as adults. When insecure, these patterns appear to contribute to paranoid interpretations about the intentions of others by indirect pathways such as negative self-esteem and a bias toward untrustworthiness.

Shifting Trend of Protein Consumption in Southeast Asia: Toward Health, Innovation, and Sustainability.

Complementing discourse following a February 2023 event on dietary protein needs in Southeast Asia (SEA), this symposium report summarizes the region's protein intake, while simultaneously examining the impact of dietary shift toward complementary and alternative proteins and their health implications. It highlights the importance of protein quality in dietary evaluations, optimal intake, and sustainability, advocating for environmentally conscious protein production and innovation in future foods. Discussion points, expert opinions, national nutrition data, and relevant literature, addressing protein intake and quality, their impact on human health, and various technologies for future foods production, have been included.

A Long Fluorescence Lifetime Probe for Labeling of Gram-Negative Bacteria.

Bacterial resistance, primarily stemming from misdiagnosis, misuse, and overuse of antibacterial medications in humans and animals, is a pressing issue. To address this, we focused on developing a fluorescent probe for the detection of bacteria, with a unique feature-an exceptionally long fluorescence lifetime, to overcome autofluorescence limitations in biological samples. The polymyxin-based probe (ADOTA-PMX) selectively targets Gram-negative bacteria and used the red-emitting fluorophore azadioxatriangulenium (with a reported fluorescence lifetime of 19.

Systematics of the complex, with evidence for 3 additional Afrotropical bat species.

Roughly a third of all horseshoe bat species (Rhinolophidae: ) are found in Africa, where a recent continent-wide genetic survey suggested the presence of both undescribed and apparently invalid species. Here, we focus on the species complex and the recent elevation of Peters, 1852, to species rank. That action created ambiguity in the taxonomy of East African members of the group-are both Martin, 1838, and sympatric in East Africa or is another, unnamed species present there? Here, we refine genetic, morphological, and behavioral characterizations of and its erstwhile synonyms with samples from the vicinity of their type localities.

Demography of the Gambian Epauletted Fruit Bat () in Ghana.

We provide the first estimates of survival and reproductive rates for a population of the Gambian Epauletted Fruit Bat in Ghana. We focused on a large colony of ca. 5,000 bats over 3 years to estimate population parameters including population size, birth rates, survival, and sex ratios for this species.

Impact of #PCOSweightloss: A global X hashtag analysis study of weight loss narratives in the PCOS community.

Introduction: Social media plays a significant role in fostering communities around health and wellness. The hashtag #PCOSweightloss has become a pivotal forum on the platform X, where individuals exchange experiences, share information, and motivate each other concerning weight loss strategies connected with Polycystic Ovary Syndrome (PCOS).

Objective: This study aims to analyze the trends of #PCOSweightloss on X to gain insights into the social media metrics, including overall hashtag reach, key themes, and potential influence on management practices of PCOS.

Revolutionizing medical education: Surgery takes the lead in virtual reality research.

Objectives: Advancements in technology have spurred a transformative shift in medical education, with virtual reality (VR) emerging as a powerful tool for enhancing the learning experience. This study analyses the publications of VR in medical education, focusing on differences within different medical specialties.

Design: Using specific search terms, all studies published on VR in medical education listed in the Web of Science databases were included.

Understanding and Deterring Online Child Grooming: A Qualitative Study.

The prevalence of online child sexual grooming offenses has been on the rise, posing significant risks to children. Child sexual grooming involves sexual communication with minors. This study aims to understand motivations and pathways of individuals who have engaged in online grooming behaviour, as well as propose effective prevention and intervention strategies.

Prevalence and determinants of faecal carriage of carbapenem- and third-generation cephalosporin-resistant Enterobacterales: a cross-sectional household survey in northern Vietnam.

Background: Antimicrobial resistance (AMR) is a silent pandemic causing 1.27 million deaths in 2019, disproportionately affecting low- and middle-income countries, but resistance among commensal microbiota and the determinants of carriage have not been widely reported. This cross-sectional household study aimed to determine the prevalence of carbapenem-resistant (CRE) and third-generation cephalosporin-resistant Enterobacterale (C3GRE) in a rural community in Ha Nam northern Vietnam, as well as the socio-demographic, behavioural, and environmental determinants of carriage.