Moderating effect of cultural differences on the association between social media use and mental health outcomes in adolescents: A cross-cultural comparison study.

The influence of social media on the mental health of adolescents has been controversial and the findings in the literature are inconclusive. Although prior studies have identified several factors that may cause or trigger the proposed relationship, little is known about the culture-related factors as an underlying mechanism that could explain the complexity of this association. This study addressed this gap by examining the associations between the two domains of social media (i.

Early life stress shifts critical periods and causes precocious visual cortex development.

The developing nervous system displays remarkable plasticity in response to sensory stimulation during critical periods of development. Critical periods may also increase the brain's vulnerability to adverse experiences. Here we show that early-life stress (ELS) in mice shifts the timing of critical periods in the visual cortex.

Exploring the impact of health literacy on pregnant women from ethnic minority groups: A scoping review.

Objective: Health Inequalities refer to disparities in healthcare access and outcomes based on social determinants of health. These inequalities disproportionately affect Black, Asian, Minority Ethnic (BAME) groups, particularly pregnant women, who face increased risks and limited access to care due to low health literacy. Maternal mortality rates for BAME women can be up to four times higher than for white women.

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate.

Gap junction intercellular communication (GJIC) between two adjacent cells involves direct exchange of cytosolic ions and small molecules via connexin gap junction channels (GJCs). Connexin GJCs have emerged as drug targets, with small molecule connexin inhibitors considered a viable therapeutic strategy in several diseases. The molecular mechanisms of GJC inhibition by known small molecule connexin inhibitors remain unknown, preventing the development of more potent and connexin-specific therapeutics.

A primary school-based dengue solution model for post-COVID-19 in southern Thailand: Students understanding of the dengue solution and larval indices surveillance system.

One of the consequences of the COVID-19 lockdown is that it hinders school-based dengue management interventions. This is due to the closure of schools and the limited availability of online lessons in certain schools. Conversely, the level of basic understanding that primary school children have about the condition is directly related to their likelihood of getting it and their ability to modify their behaviour to prevent it.

SynPlanner: An End-to-End Tool for Synthesis Planning.

SynPlanner is an end-to-end tool for designing customized retrosynthetic planners from reaction data. It includes a reaction data curation pipeline (reaction atom-to-atom mapping, reaction standardization, and filtration), reaction rule extraction, retrosynthetic model training, and retrosynthetic planning. The tool is designed to be as flexible as possible, supporting the customization of each step of the pipeline to address different needs in the development of customized retrosynthetic planning solutions.

The experience of loneliness among people with psychosis: Qualitative meta-synthesis.

Background: Loneliness can be a significant challenge for people living with psychosis. We currently lack evidence about how to help with this. Understanding the origins, experience, and impact of loneliness in this group is helpful in developing strategies to reduce it.

How and why does mode of birth affect processes for routine data collection and use? A qualitative study in Bangladesh and Tanzania.

The World Health Organization recognises Routine Health Information System (RHIS) data as integral to data-driven health systems; needed to improve intrapartum outcomes for maternal and newborn health worldwide. However, research in Bangladesh and Tanzania suggests that mode of birth affects register data accuracy, but little is known about why. To address this gap, we undertook qualitative research in these two public-sector health systems.

The PROCAN-B study protocol: Early diagnosis of PROstate CANcer for Black men-a community-centred participatory approach in Scotland and the North-East of England.

Background: Prostate cancer is the most common cancer in the UK and Black African-Caribbean men are twice as likely to develop prostate cancer as white men. These cancer inequalities need urgent tackling. Barriers to early diagnosis are complex and require complex solutions.

Ethnicity and anthropometric deficits in children: A cross-sectional analysis of national survey data from 18 countries in sub-Saharan Africa.

Child anthropometric deficits remain a major public health problem in Sub-Saharan Africa (SSA) and are a key target of the UN Sustainable Development Goals (SDGs). The SDGs recommend disaggregation of health indicators by ethnic group. However, few studies have assessed how ethnicity is associated with anthropometric deficits across SSA.

Optimization of chromium (VI) reduction in aqueous solution using magnetic Fe3O4 sludge resulting from electrocoagulation process.

The reuse of electro-coagulated sludge as an adsorbent for Cr(VI) ion reduction was investigated in this study. Electro-coagulated sludge was obtained during the removal of citric acid wastewater by the electrocoagulation process. The following parameters were optimized for Cr(VI) reduction: pH (5-7), initial Cr(VI) concentration (10-50 mg/L), contact time (10-45 min), and adsorbent dosage (0.

Effectiveness of behavior change techniques to address barriers to follow-up colonoscopy: results from an online survey and randomized factorial experiment.

Background: Nonattendance at colonoscopy is associated with reduced colorectal cancer (CRC) survival.

Purpose: The aim of this research was to quantify barriers to colonoscopy and test the effectiveness of behavior change techniques (BCTs) to address them.

Methods: Two studies were conducted.

Exploring the patient's recovery journey and information needs following a shoulder fracture: A qualitative interview study.

Background: Shoulder fractures (proximal humerus fractures) are common, painful, debilitating injuries. Recovery is a long process often hindered by complications such as mal-union and frozen shoulder. The purpose of this qualitative study was to explore the experiences and information needs of people at different time points after a shoulder fracture and how views on recovery change over time.

Medication review interventions for adults living with advanced chronic kidney disease: A scoping review.

Structured medication reviews (SMRs) were introduced into the National Health Service (NHS) Primary Care to support the delivery of the NHS Long-Term Plan for medicines optimization. SMRs improve the quality of care, reduce harm and offer value for money. However, evidence to support SMRs for patients with chronic kidney disease (CKD) stage G4-5D with elevated risk of cardiovascular disease and premature mortality is unknown.

Development of a Cochlear Implantation Program in Malawi: Audiometric and Speech Perception Results From a Series of Implantees.

Background: Malawi performed its first cochlear implantation in 2014. Since then, the number of users has grown. This larger cohort facilitates a more rigorous analysis of the hearing outcomes that have been achieved by the Malawi cochlear implant (CI) program.

Ethics and community nursing.

Iwan Dowie explores the critical role of ethics in community nursing, where nurses often make autonomous decisions in the home care of patients. Nurses are tasked with balancing individual patient rights with the broader needs of society, guided by ethical principles such as autonomy, beneficence, nonmaleficence and justice.

Implementing Wells' criteria to improve deep vein thrombosis screening in housebound patients.

Background: Screening of deep vein thrombosis (DVT) is an NHS priority for improving community health service. Effective DVT screening and documentation improve patient outcomes, prevent prolonged hospitalisation and lead to fewer expenses. The lack of evidence of DVT screening in the community requires action.

Urinary incontinence in older adult women: fighting a rising tide.

The world's population is rapidly ageing, with conditions such as urinary incontinence, which are especially prevalent among older adults, expected to rise in prevalence as a result. Urinary incontinence is particularly common in older women; however, despite its profound impact on every aspect of women's health and wellbeing, it is often minimised by both individual patients and the wider healthcare system. Francesca Ramadan delves into the prevalence of and psychosocial effects and patient-related factors related to urinary incontinence in older women.

Assisted dying legislation: challenges and considerations for community nurses.

The article focuses on assisted dying, its legislation process and why it might be a political priority for UK lawmakers at this time. The author also raises questions about what the implications of this bill for nurses, particularly community nurses. The article mentions places outside the UK where assisted dying is already a feature of healthcare.

The impact of cold weather on older people and the vital role of community nurses.

Over the past 160 years, the UK has experienced significant winter mortality among older people. A quarter of a million older people have died from cold-related illnesses over the past decade, with one older person dying every seven minutes. Misconceptions about winter deaths must be addressed.

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study.

Purpose: The purpose of this study was to identify serum metabolites associated with age-related macular degeneration (AMD) incidence and investigate whether metabolite profiles enhance AMD risk prediction.

Methods: In a prospective cohort study involving 240,317 UK Biobank participants, we assessed the associations of 168 metabolites with AMD incidence using Cox hazards models. Principal component analysis (PCA) captured 90% of the variance in metabolites.

Longitudinal Measurement Invariance of the Parenting Sense of Competence (PSoC): Evidence to Question Its Use?

Background: This study investigated the factor structure of the parenting sense of competence (PSoC), a measure of parenting self-efficacy, in a sample of parents recruited when their infants were under 2 months old. Due to the lack of longitudinal analysis of the PSoC's factor structure over time, the study sought to establish if the published two-factor structure was consistent over an 18-month period.

Methods: Data collected from 536 parents who had participated in a randomised controlled trial of universal proportionate parenting support, delivered in five sites in England, were subject to confirmatory factor analysis (CFA).

Balance between photoreduction efficiency, cofactor affinity, and allosteric coupling of halogenase flavoenzymes.

Flavin-dependent halogenases (FDHs) are promising candidates for the sustainable production of halogenated organic molecules by biocatalysis. FDHs require only oxygen, halide and a fully reduced flavin adenine dinucleotide (FADH) cofactor to generate the reactive HOX that diffuses 10 Å to the substrate binding pocket and enables regioselective oxidative halogenation. A key challenge for the application of FDHs is the regeneration of the FADH.

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma.

The incidence of oesophageal adenocarcinoma (OAC) has risen six-fold in western countries over the last forty years but survival rates have only marginally improved. Hyperactivation of the PI3K-AKT-mTOR pathway is a common occurrence in OAC, driving cell survival, proliferation and resistance to chemotherapeutic agents. Inhibition of AKT has been explored as a treatment strategy with limited success and current inhibitors have failed to progress through clinical trials.