Ocular-induced abnormal head postures: A systematic review and analysis.

Abnormal head postures (AHPs) are frequently adopted as compensatory mechanisms by individuals affected by various ocular diseases to optimize the utilization of their visual field or alleviate symptoms such as diplopia. We review the causal relationship between ocular diseases and the resulting AHPs. An extensive literature search was conducted to identify and summarize relevant medical studies providing evidence of AHPs in patients diagnosed with conditions like Duane retraction syndrome, Brown syndrome, superior oblique palsy, and other ocular disorders.

Pharmacological associations of central serous chorioretinopathy: Looking beyond corticosteroids.

Central serous chorioretinopathy (CSCR) has multiple associations and risk factors. Of these, psychological stress, corticosteroid treatment, and specific personality traits are well recognized. Other drugs, such as sympathomimetic agents, psychotropic drugs and phosphodiesterase inhibitors, are frequently incriminated.

Rheumatoid arthritis-associated interstitial lung disease: clinical characteristics and mortality in a large single-centre cohort.

Objectives: Interstitial lung disease (ILD) is a severe pulmonary complication observed in Rheumatoid Arthritis (RA) patients and is a leading cause of mortality within this population. The objective of this study is to provide a comprehensive comparative analysis of a real-world observational cohort, distinguishing between patients with and without ILD. This analysis encompasses various aspects including sociodemographic, clinical, biological, and radiological factors.

A comprehensive survey of cytotoxic active half-sandwich Ir(III) complexes: structural perspective, and mechanism of action.

Iridium(III) complexes, particularly those with piano-stool structures, have drawn a lot of interest recently as possible anticancer drugs. These complexes, which have displayed enhanced cytotoxicity and cytoselectivity compared with clinically approved drugs like cisplatin, oxaliplatin, and carboplatin, hold promising prospects for further anticancer research. Our review aims to explore the complex interplay between cytotoxic properties, cellular uptake efficiency, and intracellular distribution properties of this class of Ir(III) complexes, considering the variation of the coordination site atoms.

Tauopathy in AD: Therapeutic Potential of MARK-4.

Alzheimer's disease (AD) is one of the leading causes of cognitive decline, which leads to dementia and poses significant challenges for its therapy. The reason is primarily the ineffective available treatments targeting the underlying pathology of AD. It is a neurodegenerative disease that is mainly characterised by the various molecular pathways contributing to its complex pathology, including extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), oxidative stress, and neuroinflammation.

Clinical and Radiographic Evaluation of Bone Profile Around Dental Implants Placed in the Esthetic Zone.

Objective: To evaluate the bone profile around dental implants placed in the esthetic zone through periodontal assessment and radiographic analysis using cone-beam computed tomography (CBCT).

Methods: We conducted a clinical observational study of 35 subjects who received dental implants placed in the esthetic zone to replace lost anterior teeth. Clinical evaluation included a comprehensive periodontal examination.

Between Charybdis and Scylla-an Odyssey in AL amyloidosis: insights and learnings from a narrative review and case report series.

Being "between Scylla and Charybdis" is an idiom derived from Greek mythology to mean "between a rock and a hard place" and clinicians managing amyloid light-chain (AL) amyloidosis often find themselves in this predicament. AL amyloidosis is caused by monoclonal light chains, most commonly produced by CD-38 positive plasma cells in target organs. The disease usually involves significant cardiac and/or renal involvement, but the systemic nature of the disease often leads to variable and non-specific manifestations that can critically delay early diagnosis and treatment.

Physicians' Perspectives on Barriers to Multiple Sclerosis Care in the United Arab Emirates: A Survey Study.

Introduction: Multiple Sclerosis care in the United Arab Emirates faces several barriers impacting patient outcomes and healthcare delivery. This study aims to identify and analyze these barriers from the perspective of neurologists.

Methods: In February 2024, a survey was conducted targeting neurologists involved in Multiple Sclerosis management in Abu Dhabi.

Clinical, pathological, and genotypic analysis of infectious bronchitis virus in broiler chickens in the Abu Dhabi Emirate, United Arab Emirates.

Background: Infectious Bronchitis (IB), caused by the infectious bronchitis virus (IBV), is a significant contagious respiratory disease in the poultry industry. The emergence of new variants represents a global challenge for the diagnosis and control of the disease. Despite vaccination efforts in poultry farms in the Abu Dhabi Emirate, United Arab Emirates (UAE), outbreaks continue to occur, raising concerns about the efficacy of vaccination protocols and the potential emergence of new viral strains.

Concomitant Infection of and Intestinal Parasites: Burden, Sociodemographic and Clinical Characteristics in Hospitalized Children and Adolescents in Northern Lebanon.

Background: and intestinal parasites are well-known for their high prevalence in children, especially in developing countries. However, their concomitant infections are poorly documented. In this study, we aimed to evaluate the association between intestinal parasites and among hospitalized children and adolescents with upper gastrointestinal complaints in Northern Lebanon.

Neck pain and distance learning: A pain in the neck for university students during COVID-19.

Objective: The shift to online learning during COVID-19 led to increased musculoskeletal discomforts and impacted students' quality of life.Neck pain (NP), once a minor issue, has become more prevalent due to prolonged electronic device use in new learning methods.This study aims to measure the prevalence of NP among University of Sharjah (UOS) students during the COVID-19 online learning period and to investigate the factors that provoked it.

Assessment of potential drug-drug interactions in hospitalized patients with infectious diseases: an experience from a secondary care hospital.

Background: Polypharmacy is common among hospitalized patients with infectious infections owing to comorbidities or concurrent illnesses. This raises the likelihood of drug-drug interactions and creates uncertainty for healthcare providers. This study aimed to assess the potential drug-drug interactions (pDDIs) among hospitalized patients with infectious diseases in a secondary care hospital.

Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis.

Objective: To evaluate and quantitatively describe age-dependent homeostasis for a broad range of total T-cells and specific T-lymphocyte subpopulations in healthy human subjects.

Methods: A systematic literature review was performed to identify and collect relevant quantitative information on T-lymphocyte counts in human blood and various organs. Both individual subject and grouped (aggregated) data on T-lymphocyte observations in absolute and relative values were digitized and curated; cell phenotypes, gating strategies for flow cytometry analyses, organs from which observations were obtained, subjects' number and age were also systematically inventoried.

Cellular therapies in rheumatic and musculoskeletal diseases.

A substantial proportion of patients diagnosed with rheumatologic and musculoskeletal diseases (RMDs) exhibit resistance to conventional therapies or experience recurrent symptoms. These diseases, which include autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus, are marked by the presence of autoreactive B cells that play a critical role in their pathogenesis. The persistence of these autoreactive B cells within lymphatic organs and inflamed tissues impairs the effectiveness of B-cell-depleting monoclonal antibodies like rituximab.

The Atrial Fibrillation Registry (The FLOW-AF Registry): Insights From the United Arab Emirates-Patient Characteristics, Treatment, and One-Year Outcomes.

Background: The epidemiological landscape and treatment efficacy of atrial fibrillation (AF) in the Middle East, notably in the United Arab Emirates (UAE), remain under-explored, presenting a distinct demographic and clinical pattern compared to Western populations. The FLOW-AF Registry aimed to bridge this knowledge gap by examining the characteristics, treatment patterns, clinical outcomes, and healthcare resource utilization (HCRU) of newly diagnosed non-valvular atrial fibrillation (NVAF) patients in the UAE, contributing to the scant literature on NVAF management in the region.

Methods: This multicenter, prospective observational study enrolled patients diagnosed with NVAF across six sites in the UAE.

The association of binge eating with internet addiction, body shape concerns, and BMI among university students in the United Arab Emirates.

Background: Binge-eating disorder (BED) is the most common eating disorder with university students being particularly vulnerable. The study aimed to investigate the association between binge eating and Internet addiction (IA), body shape (BS) concerns, and body mass index (BMI) among university students.

Methods: In this cross-sectional study, 448 university students (221 males and 227 females) aged between 18 and 25 years were recruited.

Remote online learning reimagined: perceptions and experiences of medical students in a post-pandemic world.

Background: Blended learning is a key educational methodology, particularly in medical education, and involves integration of online and face-to-face interactions to enhance flexibility and engagement. Blended learning gained increased popularity during the COVID-19 pandemic due to social restrictions. Following control of the pandemic, face to face teaching and learning activities have been restored.

A scoping review on early childhood caries and inequalities using the Sustainable Development Goal 10 framework.

Background: Social inequalities contribute to health disparities. This study aimed to map evidence on early childhood caries (ECC) related to the United Nations' Sustainable Development Goal 10 (SDG 10).

Methods: A scoping review was conducted in May 2024 following the PRISMA-ScR guidelines.

Reservoir computing approaches to unsupervised concept drift detection in dynamical systems.

While the assumption that dynamical systems are stationary is common for modeling purposes, in reality, this is rarely the case. Rather, these systems can change over time, a phenomenon referred to as concept drift in the modeling community. While there exist numerous statistics-based methods for concept drift detection on stochastic processes, approaches leveraging nonlinear time series analysis (NTSA) are rarer but seeing increased focus in cases where the processes are deterministic.

Genome wide association study reveals novel associations with face morphology.

Genome-wide association studies (GWAS) on the Middle Eastern population, including the United Arab Emirates (UAE), have been relatively limited. The present study aims to investigate genotype-face morphology associations in the UAE population through Genome Wide Association Studies (GWAS). Phenotypic data (44 face measurements) from 172 Emiratis was obtained through three-dimensional (3D) scanning technology and an automatic face landmarking technique.

Epidemiology of Multiple Sclerosis: Global, Regional, National and Sub-National-Level Estimates and Future Projections.

Background: The epidemiology of multiple sclerosis (MS) is complex due to the interaction of various risk factors. This study assesses the global, regional, national and sub-national burden of MS and predicts future trends.

Methods: Data from the Global Burden of Disease Study 2021 was analyzed to assess the epidemiology of MS from 1990 to 2021.

Blade pitching in vertical axis wind turbines: A double multiple stream tube theoretical approach to performance enhancement.

This research delves into the performance enhancement of Vertical Axis Wind Turbines (VAWTs) through the innovative approach of variable blade pitching based on Double Multiple Stream Tube theory principles. VAWTs, known for their potential in urban and low-wind environment, often face efficiency and energy yield challenges. This study addresses these challenges by proposing a novel variable blade pitching mechanism that dynamically adapts to changing wind conditions, optimizing the aerodynamic performance, and enhancing the torque and overall performance of VAWT rotor.

Liraglutide Effect on Weight and A1C in Patients with Type 2 Diabetes Mellitus: Real-World Data from a Single Tertiary Care Center in Saudi Arabia.

Objective: This retrospective study aimed to determine the effect of liraglutide on weight and HbA1c levels in patients with type 2 diabetes mellitus (T2DM) in Saudi Arabia. The present investigation was carried out at a medical facility located in the Kingdom of Saudi Arabia.

Materials And Methods: A retrospective analysis was conducted on the clinical records of 290 patients who were diagnosed with T2DM and were above 18 years of age.

Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants.

Context: Bisphosphonates are extensively used drugs for the management of osteoporosis and other disorders affecting the bones. The stability and lifetime of osseointegrated dental implants may be influenced by their impact on bone metabolism.

Materials And Methods: A randomized controlled trial was undertaken with a sample size of 60 individuals who were implanted with orally integrated dental implants.