Real-World Effectiveness of Intravenous Belimumab on Clinical Outcomes in Patients With Systemic Lupus Erythematosus in Saudi Arabia: The OBSErve Observational Study.

Purpose: To describe intravenous (IV) belimumab's clinical effectiveness in patients with systemic lupus erythematosus (SLE) in real-world practice in Saudi Arabia.

Patients And Methods: This retrospective, observational OBSErve study (GSK Study 215349) analyzed medical record data for adults with SLE receiving IV belimumab. Index date was the date of belimumab initiation.

An efficient sparse code shrinkage technique for ECG denoising using empirical mode decomposition.

Accurate denoising of Electrocardiogram (ECG) signals is essential for reliable cardiac diagnostics, but traditional methods often struggle with high-frequency noise and artifacts, leading to potential misinterpretations. It is often impeded by interference such as power line interference (PLI) and Gaussian noise. To address this challenge, we suggest a novel ECG denoising technique that combines empirical mode decomposition (EMD) with wavelet domain sparse code shrinking.

"I am responsible": Perceptions of employees on health and safety program implementation in small and medium sized businesses in Indonesia.

Background: Prior research conducted in the small bag manufacturing sector in Indonesia reported that occupational injuries occurred almost every month, with some workers reporting severe injuries that led to their fingers being amputated. Another study mentioned that the food manufacturing sectors tend to be more focused on improving their production activities than on paying attention to protecting their workers. Despite these conditions, employees are commonly seen by the owners as being responsible for their own safety at the workplace.

Interdisciplinary Hybrid Solar-Driven Evaporators: Theoretical Framework of Fundamental Mechanisms and Applications.

The global water and energy crisis seems to be mitigated with promising prospects of emerging interdisciplinary hybrid solar-driven evaporator technology (IHSE). However, the lack of numeric standards for comparison between enormously reported systems and the synergistic effects of interdisciplinary hybridization remains a significant challenge. To entice researchers from various domains to collaborate on the design of a system for realistic, large-scale applications, this study provides a comprehensive overview of the interdisciplinary approaches to IHSE from the domains of physics, chemistry, materials science, and engineering, along with their guiding principles and underlying challenges.

Improving the structure of lentil proteins during fermentation and their association with nutritional values and solubility.

Lentil proteins (LPs) may encounter challenges in their food industry applications due to certain limitations in their functional properties. This study focused on enhancing the quality of LPs through physical modifications and investigating the effects of a 24-hr fermentation process with . The protein structures of LPs were analysed using several techniques, including ultraviolet spectra, fluorescence spectra, and FT-IR spectra, respectively, resulting in the protein structure of LPs substantial modifications ( 0.

Utilitarian psychology and influenza vaccine acceptance in the United Arab Emirates: implications for moral education and public policy.

Seasonal influenza is still a challenge in the United Arab Emirates (UAE). There is consensus that the most effective way to address this problem is through yearly vaccination campaigns. Despite governmental efforts to make the influenza vaccine available, there remains some hesitancy among the population.

Effects of neuromuscular electrical stimulation during hemodialysis on muscle strength, functional capacity and postural balance in patients with end-stage renal disease: a randomized controlled trial.

Background: Hemodialysis patients (HD) have a limited physical capacity and this often means low adherence to rehabilitation programs based on conventional exercise. This study investigated the effectiveness of neuromuscular electrical stimulation (NMES) during HD therapy on muscle strength, functional capacity and postural balance in HD patients.

Methods: Twenty-two HD patients were randomly assigned to a control group (CG) or a neuromuscular electrical stimulation training group (NSTG).

Gut microbiota composition of lean and obese Lebanese individuals.

An altered gut microbiota has been shown to contribute to the development of metabolic diseases such as obesity. In this study gut microbiota profile of 30 obese and 23 lean Lebanese individuals was performed via DNA isolation and sequencing of the V3-V4 region of the 16S rRNA of faecal samples. The abundance of the phylum Verrucomicrobiota was higher in lean subjects and there was no significant difference in the Bacillota/ Bacteroidota ratio between the obese and lean groups.

Examining the Role of AI in Changing the Role of Nurses in Patient Care: Systematic Review.

Background: This review investigates the relationship between artificial intelligence (AI) use and the role of nurses in patient care. AI exists in health care for clinical decision support, disease management, patient engagement, and operational improvement and will continue to grow in popularity, especially in the nursing field.

Objective: We aim to examine whether AI integration into nursing practice may have led to a change in the role of nurses in patient care.

Evaluating the structure-based virtual screening performance of SARS-CoV-2 main protease: A benchmarking approach and a multistage screening example against the wild-type and Omicron variants.

COVID-19 still poses a worldwide health threat due to continuous viral mutations and potential resistance to vaccination. SARS-CoV-2 viral multiplication hindrance by inhibiting the viral main protease (Mpro) deemed propitious. Structure-based virtual screening (SBVS) is a conventional strategy for discovering new inhibitors.

Multidisciplinary Evaluation for COPD Management.

COPD is a heterogeneous disorder. We developed a multidisciplinary evaluation scheme to identify patients with COPD who may benefit from phenotype-specific therapy. Our team of general and interventional pulmonologists, thoracic surgeons, radiologists, respiratory therapists, and advanced practice nurses meets monthly to discuss patients with advanced COPD.

Intranasal dupilumab improves responsiveness to steroid in an asthma mouse model.

Aims: The study aimed to evaluate the efficacy of local intranasal delivery of dupilumab, a monoclonal antibody targeting IL-4Rα, in comparison to intraperitoneal delivery in a mouse model of steroid-hyporesponsive asthma, a condition characterized by limited therapeutic options.

Methods: Dupilumab was administered via both intranasal and intraperitoneal routes to a mouse model of steroid-hyporesponsive asthma. The efficacy of the treatment was assessed through histological evaluations of inflammation and goblet cell metaplasia, analysis of immune cell infiltration in bronchoalveolar lavage fluid via cytospin, and measurement of total airway resistance using FlexiVent.

Factors influencing trust in algorithmic decision-making: an indirect scenario-based experiment.

Algorithms are involved in decisions ranging from trivial to significant, but people often express distrust toward them. Research suggests that educational efforts to explain how algorithms work may help mitigate this distrust. In a study of 1,921 participants from 20 countries, we examined differences in algorithmic trust for low-stakes and high-stakes decisions.

Development and pilot testing of a comprehensive and culturally-sensitive infant feeding descriptive questionnaire: a cross-sectional design.

Background: Infant feeding tools available in the literature lack comprehensiveness and inclusiveness to infants of different ages. This study aimed to pilot test a newly developed infant feeding descriptive questionnaire.

Methods: This study utilized a cross-sectional design.

Peptide-based fluorescent probes for the diagnosis of tumor and image-guided surgery.

Fluorescent contrast agents are instrumental in amplifying signals, thereby enhancing the sensitivity and accuracy of live optical imaging. However, a significant proportion of traditional fluorescent contrast agents exhibit drawbacks such as short half-life, suboptimal biocompatibility, and inadequate tumor targeting, all of which impede effective imaging guidance. Peptides, derived from natural structures, offer a flexible modular design that can be precisely engineered and adjusted using synthetic methods to achieve specific biological activity and pharmacokinetic properties.

Indications and Outcomes of Endoscopic Gastric Pouch Plications After Bariatric Surgery: An Analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) Database.

Background: Endoscopic gastric pouch plications (EGPP) have emerged as a novel approach for managing weight-related issues and postoperative complications following bariatric surgery. However, safety for these revisions remains limited. This study aims to evaluate the 30-day rate of serious complications and mortality associated with EGPP using the MBSAQIP database.

Developmental validation of the AGCU EX-38 typing system: a comprehensive forensic tool for enhanced genetic identification.

The necessity for developing the AGCU EX-38 typing system arises from the ever-increasing demand for more accurate and comprehensive forensic tools. Traditional kits with fewer STRs often fall short in complex cases requiring higher resolution. The AGCU EX-38 typing system incorporates 35 autosomal STRs, including extended CODIS loci as well as additional non-CODIS loci (D6S1043, D19S3045, D3S3045, D7S3048, D11S2368, D4S2366, D8S1132, D15S659, Penta D, Penta E, D6S447, D3S1744, D14S608, D18S535).

Niosomes as a targeted drug delivery system in the treatment of breast cancer: preparation, classification and mechanisms of cellular uptake.

Breast cancer (BC) remains one of the significant health issues across the globe, being diagnosed in millions of women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, being novel drug delivery systems formed from non-ionic surfactants, with or without cholesterol and charge-inducing agents, are used as therapeutic options in treating BC.

Comparing AI and human-generated health messages in an Arabic cultural context.

Background: AI is rapidly transforming the design of communication messages across various sectors, including health and safety. However, little is known about its effectiveness for roughly 420 million native Arabic speakers worldwide.

Objective: This study examined characteristics of AI vs.

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Association of contraception use and pregnancy intention with perinatal depression risk among Omani mothers-a longitudinal cohort study.

Background: Unplanned pregnancy is significantly associated with an increased risk of perinatal depression (antenatal and postnatal depression), emphasizing its prevalence and its potentially detrimental effects on both maternal and child health. This study aimed to investigate the association of contraception use and pregnancy intention with the risk of perinatal depression among Omani mothers.

Methods: A prospective longitudinal study design was employed to investigate perinatal depression risk in mothers attending antenatal health care services in Oman.

Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set in 2004 on ACLF was published in 2009, and the "APASL ACLF Research Consortium (AARC)" was formed in 2012.