The Meaning in Life Questionnaire: Revisiting the Evidence of Validity and Measurement Invariance Using the Exploratory Structural Equation Modeling.

The Meaning in Life Questionnaire (MLQ) assesses two distinct dimensions of meaning in life: presence of meaning and search for meaning. The MLQ is the most widely used instrument for measuring meaning in life, yet there is a limited variety of validity evidence on the originally proposed two-factor confirmatory factor analysis (CFA) solution. In this light, the present research examined, across five studies (total = 3,205), several aspects of the MLQ's validity and tested cross-gender and cross-national measurement invariance.

Phonon-Induced Wake Potential in a Graphene-Insulator -Graphene Structure.

The aim of this study is to explore the potential which arises in a graphene-insulator-graphene structure when an external charged particle is moving parallel to it with a speed smaller than the Fermi speed in graphene. This is achieved by employing the dynamic polarization function of graphene within the random phase approximation, where its π electrons are modeled as Dirac fermions, and utilizing a local dielectric function for bulk insulators. Three different insulators are considered: SiO, HfO, and AlO.

Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function.

Oxidative stress (OS) is one of the factors that result in cell damage and the development of neurological diseases such as Alzheimer's disease (AD). Astaxanthin (ASTA), a natural compound known for its potent antioxidant properties, shows the biological activities in anti-apoptosis and antitumor. However, its specific mechanism on mitochondrial function remains unclear.

Benzylisoquinoline alkaloids from the embryo of Nelumbo nucifera and their antioxidant effects.

Seven benzylisoquinoline alkaloids, including three new (1-3) and four known compounds (4-7), were isolated from the embryo of Nelumbo nucifera (Plumula Nelumbinis). Their structures were elucidated by UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra, as well as optical rotations. All compounds were tested for the antioxidant activity.

Global distribution and decline of mangrove coastal protection extends far beyond area loss.

Mangroves protect coasts from extreme weather and erosion but can be destroyed by climate change and harvesting. However, there is no consistent formulation of protective capacity that integrates key factors such as area, width, height, and health. Here, we quantified and analyzed a process-based measure of mangrove coastal protection index (MCPI) incorporating cross-shore width, canopy height, and the normalized difference vegetation index (health index).

Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease.

Alzheimer's disease (AD) is an age-related degenerative disease, which is characteristic by the deposition of senile plaques (SP) outside the cells, the neurofibrillary tangles (NFTs) inside the neurons, and the loss of synapse and neurons. Neuroinflammation may play an important role in the pathogenesis of AD. Microglia are the immune cells in the central nervous system.

Stochastic model of seed dispersal with homogeneous and non-homogeneous Poisson processes under habitat reduction conditions.

This study presents a stochastic model of seed dispersal based on a branching random walk (BRW) framework, incorporating both homogeneous and non-homogeneous Poisson point processes (PPP). Building on the model introduced by Coletti et al. (2023), we examine the effects of habitat reduction on seed dispersal dynamics.

Multi-module engineering to guide the development of an efficient L-threonine-producing cell factory.

The rapid development of high-productivity strains is fundamental for bio-manufacture in industry. Here, Multi-module metabolic engineering was implemented to reprogram Escherichia coli, enabling it to rapidly transitioning from zero-producer to hyperproducer of L-threonine. Firstly, the synthesis pathway of L-threonine was rationally divided into five modules, and the rapid production of L-threonine was achieved by optimizing the expression of genes in each module.

Implementation and Evaluation of APOTECAchemo in a Community Cancer Center: A Comparative Study of Robotic Versus Manual Antineoplastic Preparation.

The ever-increasing complexity and demand for antineoplastic therapy necessitates innovative solutions to improve the accuracy and safety of drug preparation. To evaluate the utilization of an advanced robotic chemotherapy drug compounding system (APOTECAchemo) at a Community Cancer Center (CCC), examining accuracy, efficiency, and staff perceptions. This single-center, retrospective study evaluated the preparation of 7 intravenous (IV) antineoplastics at a CCC over a 1-year period.

Engaging a New Treatment Paradigm: Elranatamab in Relapsed/Refractory Multiple Myeloma.

Objective: To review the therapeutic profile of elranatamab, a novel bispecific T-cell-redirecting therapy, in treating relapsed or refractory (R/R) multiple myeloma (MM).

Data Sources: A PubMed search was conducted for English-language articles published from January 2000 through June 2024, using the search terms: , and "" Additional data were obtained from ClinicalTrials.gov and other pertinent publications and meeting abstracts.

Differences in the Determination of Volatile Organic Compounds between Ramat. and L. (Wild Chrysanthemum) by HS-GC-IMS.

Chrysanthemums and wild chrysanthemums are herbs with high application value. As edible plants of the Asteraceae family, they have good antioxidant, anti-inflammatory and hepatoprotective properties. Chrysanthemums and wild chrysanthemums contain a wide variety of volatile organic compounds, and these volatile components are the main factors contributing to the flavor differences.

Mechanistic study of synergetic stabilization of Pickering emulsions by corn glutelin and starch complexes.

The hydrophobicity of glutelin, zein, and carotenoids has limited the development of corn-based functional food products. This paper aims to construct emulsions stabilized by multiple corn-derived components using a simple and organic solvent-free method. The emulsions comprised oil droplets dispersed in the water, where glutelin and starch were stabilizers.

Engineering for l-Threonine Hyperproduction Based on Multidimensional Optimization Strategies.

Exploring effective remodeling strategies to further improve the productivity of high-yield strains is the goal of biomanufacturing. However, the lack of insight into host-specific metabolic networks prevents timely identification of useful engineering targets. Here, multidimensional engineering strategies were implemented to optimize the global metabolic network for improving l-threonine production.

DSC-Net: Enhancing Blind Road Semantic Segmentation with Visual Sensor Using a Dual-Branch Swin-CNN Architecture.

In modern urban environments, visual sensors are crucial for enhancing the functionality of navigation systems, particularly for devices designed for visually impaired individuals. The high-resolution images captured by these sensors form the basis for understanding the surrounding environment and identifying key landmarks. However, the core challenge in the semantic segmentation of blind roads lies in the effective extraction of global context and edge features.

Vehicle detection and classification using an ensemble of EfficientDet and YOLOv8.

With the rapid increase in vehicle numbers, efficient traffic management has become a critical challenge for society. Traditional methods of vehicle detection and classification often struggle with the diverse characteristics of vehicles, such as varying shapes, colors, edges, shadows, and textures. To address this, we proposed an innovative ensemble method that combines two state-of-the-art deep learning models EfficientDet and YOLOv8.