1 results match your criteria: "Union Hospital Affiliated to Huazhong Science and Technology University[Affiliation]"
[Activation of Kupffer cell TLR2 signaling pathway during hepatic ischemia/reperfusion injury process in mice and it's significance].
Zhonghua Gan Zang Bing Za Zhi
June 2005
Emergency Surgery Department, Union Hospital Affiliated to Huazhong Science and Technology University, Wuhan 430022, China.
Objective: To study changes of TLR2 signaling pathway expression in Kupffer cells during the process of hepatic ischemia/reperfusion in a mice model and the mechanism of TLR2 signaling pathway participating in hepatic ischemia/reperfusion injury.
Methods: BALB/c mice were divided into 3 groups: sham operation (SH), ischemia/reperfusion (I/R) and GdCl3 treatment (Gd) groups. After 4 h of reperfusion, the expression of TLR2 mRNA and membrane TLR2 protein were analyzed in ischemic lobes of the livers, and in Kupffer cells isolated from ischemic lobes.